hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04315
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HLA-DRB1 | HLA class II histocompatibility antigen, DRB1-3 chain (Clone P2-beta-3) (MHC class II antigen DRB1*3) | UniProt NCBI |
| HLA-DRB5 | HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05310 | 1.13800084426e-05 | 1.0 | HLA-DRB1 HLA-DRB5 | Asthma |
| KEGG:05330 | 3.06384842685e-05 | 1.0 | HLA-DRB1 HLA-DRB5 | Allograft rejection |
| KEGG:05332 | 4.37692632407e-05 | 1.0 | HLA-DRB1 HLA-DRB5 | Graft-versus-host disease |
| KEGG:04672 | 4.7416701844e-05 | 1.0 | HLA-DRB1 HLA-DRB5 | Intestinal immune network for IgA production |
| KEGG:04940 | 5.9234402919e-05 | 1.0 | HLA-DRB1 HLA-DRB5 | Type I diabetes mellitus |
| KEGG:05320 | 8.68090387606e-05 | 1.0 | HLA-DRB1 HLA-DRB5 | Autoimmune thyroid disease |
| REAC:R-HSA-202430 | 0.000110610948517 | 1.0 | HLA-DRB1 HLA-DRB5 | Translocation of ZAP-70 to Immunological synapse |
| KEGG:05321 | 0.000138019076752 | 1.0 | HLA-DRB1 HLA-DRB5 | Inflammatory bowel disease (IBD) |
| KEGG:05416 | 0.00015100395818 | 1.0 | HLA-DRB1 HLA-DRB5 | Viral myocarditis |
| REAC:R-HSA-202427 | 0.000175971963549 | 1.0 | HLA-DRB1 HLA-DRB5 | Phosphorylation of CD3 and TCR zeta chains |
| KEGG:04640 | 0.000201046815819 | 1.0 | HLA-DRB1 HLA-DRB5 | Hematopoietic cell lineage |
| KEGG:04612 | 0.000208779385658 | 1.0 | HLA-DRB1 HLA-DRB5 | Antigen processing and presentation |
| KEGG:05323 | 0.000224682217969 | 1.0 | HLA-DRB1 HLA-DRB5 | Rheumatoid arthritis |
| REAC:R-HSA-389948 | 0.000227925590883 | 1.0 | HLA-DRB1 HLA-DRB5 | PD-1 signaling |
| KEGG:05140 | 0.00023285248044 | 1.0 | HLA-DRB1 HLA-DRB5 | Leishmaniasis |
| KEGG:05150 | 0.000312950232171 | 1.0 | HLA-DRB1 HLA-DRB5 | Staphylococcus aureus infection |
| KEGG:04658 | 0.000362555397177 | 1.0 | HLA-DRB1 HLA-DRB5 | Th1 and Th2 cell differentiation |
| REAC:R-HSA-202433 | 0.000502777038712 | 1.0 | HLA-DRB1 HLA-DRB5 | Generation of second messenger molecules |
| KEGG:04659 | 0.000533255523815 | 1.0 | HLA-DRB1 HLA-DRB5 | Th17 cell differentiation |
| WP:WP2328 | 0.00061587694133 | 1.0 | HLA-DRB1 HLA-DRB5 | Allograft Rejection |
| KEGG:05145 | 0.000637718165416 | 1.0 | HLA-DRB1 HLA-DRB5 | Toxoplasmosis |
| KEGG:04514 | 0.000736782597884 | 1.0 | HLA-DRB1 HLA-DRB5 | Cell adhesion molecules (CAMs) |
| KEGG:05322 | 0.00092323965929 | 1.0 | HLA-DRB1 HLA-DRB5 | Systemic lupus erythematosus |
| KEGG:04145 | 0.00131964328671 | 1.0 | HLA-DRB1 HLA-DRB5 | Phagosome |
| KEGG:05164 | 0.00158707348511 | 1.0 | HLA-DRB1 HLA-DRB5 | Influenza A |
| KEGG:05152 | 0.00163040505571 | 1.0 | HLA-DRB1 HLA-DRB5 | Tuberculosis |
| REAC:R-HSA-388841 | 0.00239824647466 | 1.0 | HLA-DRB1 HLA-DRB5 | Costimulation by the CD28 family |
| KEGG:05169 | 0.00242963180249 | 1.0 | HLA-DRB1 HLA-DRB5 | Epstein-Barr virus infection |
| WP:WP4217 | 0.00257192893285 | 1.0 | HLA-DRB1 HLA-DRB5 | Ebola Virus Pathway on Host |
| KEGG:05166 | 0.00281669798708 | 1.0 | HLA-DRB1 HLA-DRB5 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-877300 | 0.00465068760809 | 1.0 | HLA-DRB1 HLA-DRB5 | Interferon gamma signaling |
| REAC:R-HSA-202424 | 0.00656291627866 | 1.0 | HLA-DRB1 HLA-DRB5 | Downstream TCR signaling |
| REAC:R-HSA-202403 | 0.00950416195513 | 1.0 | HLA-DRB1 HLA-DRB5 | TCR signaling |
| KEGG:05168 | 0.010450786984 | 1.0 | HLA-DRB1 HLA-DRB5 | Herpes simplex virus 1 infection |
| REAC:R-HSA-2132295 | 0.011178409494 | 1.0 | HLA-DRB1 HLA-DRB5 | MHC class II antigen presentation |
| MIRNA:hsa-miR-141-5p | 0.0193908382967 | 1.0 | HLA-DRB1 HLA-DRB5 | hsa-miR-141-5p |
| GO:0042613 | 0.020287053512 | 1.0 | HLA-DRB1 HLA-DRB5 | MHC class II protein complex |
| REAC:R-HSA-913531 | 0.0252243240322 | 1.0 | HLA-DRB1 HLA-DRB5 | Interferon Signaling |
| MIRNA:hsa-miR-1250-3p | 0.0399386089623 | 1.0 | HLA-DRB1 HLA-DRB5 | hsa-miR-1250-3p |
| HP:0007734 | 0.0497341708567 | 0.5 | HLA-DRB1 | Enlarged lacrimal glands |
| HP:0012424 | 0.0497341708567 | 0.5 | HLA-DRB1 | Chorioretinitis |
| HP:0100828 | 0.0497341708567 | 0.5 | HLA-DRB1 | Increased T cell count |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HLA-DRB1 | 100294276 | 0.97 | 0.881 | bioplex (HLA-DRB1) bioplex_WMM |
| HLA-DRB1 | HLA-DRB5 | 0.954 | 0.861 | bioplex (HLA-DRB1) bioplex_WMM |
| HLA-DRB5 | 100294276 | 0.009 | 0.097 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04315 has an average edge precision of 0.613 which is ranked 1873 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HLA-DRB1 | HuMAP2_00757 HuMAP2_03879 HuMAP2_04315 HuMAP2_06394 |
| HLA-DRB5 | HuMAP2_00757 HuMAP2_03879 HuMAP2_04315 HuMAP2_06394 |