hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04317
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLC7A5 | Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter) | UniProt NCBI |
| DMC1 | Meiotic recombination protein DMC1/LIM15 homolog | UniProt NCBI |
| NCSTN | Nicastrin | UniProt NCBI |
| RAD51 | DNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A) | UniProt NCBI |
| ACTA1 | Actin, alpha skeletal muscle (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | UniProt NCBI |
| TNN | Tenascin-N (TN-N) (Tenascin-W) (TN-W) | UniProt NCBI |
| ANXA8 | Annexin A8 (Annexin VIII) (Annexin-8) (Vascular anticoagulant-beta) (VAC-beta) | UniProt NCBI |
| PPP1R1A | Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000150 | 0.0126230555186 | 0.25 | DMC1 RAD51 | recombinase activity |
| GO:0000730 | 0.0126230555186 | 0.25 | DMC1 RAD51 | DNA recombinase assembly |
| GO:0090735 | 0.0126230555186 | 0.25 | DMC1 RAD51 | DNA repair complex assembly |
| MIRNA:hsa-miR-769-5p | 0.0391945519483 | 0.375 | NCSTN SLC7A5 RAD51 | hsa-miR-769-5p |
| CORUM:2824 | 0.0497224828424 | 0.125 | RAD51 | BRCA1-RAD51 complex |
| CORUM:5683 | 0.0497224828424 | 0.125 | RAD51 | hRAD51C-hXRCC3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ANXA8 | ACTA1 | 1.0 | 0.949 | bioplex (ANXA8) |
| DMC1 | ACTA1 | 0.996 | 0.928 | bioplex (DMC1) bioplex_WMM |
| PPP1R1A | ACTA1 | 0.734 | 0.738 | bioplex (PPP1R1A) bioplex_WMM |
| DMC1 | RAD51 | 0.488 | 0.616 | bioplex (DMC1) bioplex_WMM |
| NCSTN | ACTA1 | 0.138 | 0.407 | bioplex (NCSTN) bioplex_WMM |
| TNN | PPP1R1A | 0.067 | 0.351 | bioplex (PPP1R1A) bioplex_WMM |
| NCSTN | SLC7A5 | 0.026 | 0.216 | hein_WMM bioplex_WMM boldt hein (NCSTN) boldt_WMM |
| TNN | ACTA1 | 0.008 | 0.086 | bioplex_WMM WMM_only |
| RAD51 | ACTA1 | 0.008 | 0.025 | bioplex_WMM youn_WMM WMM_only |
| SLC7A5 | ACTA1 | 0.007 | 0.006 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| SLC7A5 | RAD51 | 0.007 | 0.004 | youn_WMM WMM_only |
| SLC7A5 | PPP1R1A | 0.007 | 0.001 | bioplex_WMM WMM_only |
| NCSTN | PPP1R1A | 0.007 | 0.0 | bioplex_WMM WMM_only |
| SLC7A5 | DMC1 | 0.005 | 0.014 | bioplex (DMC1) |
Images
Click to enlarge
Complex HuMAP2_04317 has an average edge precision of 0.31 which is ranked 4452 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SLC7A5 | HuMAP2_00105 HuMAP2_04317 HuMAP2_04586 HuMAP2_05358 |
| DMC1 | HuMAP2_02087 HuMAP2_02714 HuMAP2_04317 HuMAP2_04403 HuMAP2_05507 |
| NCSTN | HuMAP2_00105 HuMAP2_04317 HuMAP2_04403 HuMAP2_04586 HuMAP2_05358 |
| RAD51 | HuMAP2_02087 HuMAP2_04317 HuMAP2_05507 |
| ACTA1 | HuMAP2_02714 HuMAP2_04317 HuMAP2_04403 |
| TNN | HuMAP2_01372 HuMAP2_04317 HuMAP2_05815 HuMAP2_06066 |
| ANXA8 | HuMAP2_02714 HuMAP2_04317 HuMAP2_04403 |
| PPP1R1A | HuMAP2_01372 HuMAP2_02714 HuMAP2_04317 HuMAP2_04403 HuMAP2_05815 HuMAP2_06066 |