hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04319
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UBQLN2 | Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2) | UniProt NCBI |
| AK2 | Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed] | UniProt NCBI |
| ACSF3 | Acyl-CoA synthetase family member 3, mitochondrial (EC 6.2.1.-) | UniProt NCBI |
| TXNDC17 | Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5) | UniProt NCBI |
| IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | UniProt NCBI |
| IDH2 | Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3585 | 0.000200941842998 | 0.333333333333 | IDH2 IDH1 | Cytosine methylation |
| KEGG:01210 | 0.000849270468049 | 0.333333333333 | IDH2 IDH1 | 2-Oxocarboxylic acid metabolism |
| HP:0006765 | 0.00112625143517 | 0.333333333333 | IDH2 IDH1 | Chondrosarcoma |
| HP:0005701 | 0.00210158306671 | 0.333333333333 | IDH2 IDH1 | Multiple enchondromatosis |
| HP:0200042 | 0.00241935032153 | 0.5 | AK2 IDH1 IDH2 | Skin ulcer |
| KEGG:00020 | 0.0025298764655 | 0.333333333333 | IDH2 IDH1 | Citrate cycle (TCA cycle) |
| HP:0100764 | 0.00270155144475 | 0.333333333333 | IDH2 IDH1 | Lymphangioma |
| HP:0100705 | 0.00570901006754 | 0.5 | UBQLN2 IDH1 IDH2 | Abnormality of the glial cells |
| GO:0004450 | 0.00676235117068 | 0.333333333333 | IDH2 IDH1 | isocitrate dehydrogenase (NADP+) activity |
| KEGG:00480 | 0.00730169216832 | 0.333333333333 | IDH2 IDH1 | Glutathione metabolism |
| HP:0002897 | 0.00787106080828 | 0.333333333333 | IDH2 IDH1 | Parathyroid adenoma |
| HP:0100761 | 0.00787106080828 | 0.333333333333 | IDH2 IDH1 | Visceral angiomatosis |
| HP:0100733 | 0.00787106080828 | 0.333333333333 | IDH2 IDH1 | Neoplasm of the parathyroid gland |
| HP:0030038 | 0.00787106080828 | 0.333333333333 | IDH2 IDH1 | Enchondroma |
| HP:0002763 | 0.0101912456166 | 0.333333333333 | IDH2 IDH1 | Abnormal cartilage morphology |
| HP:0007461 | 0.0101912456166 | 0.333333333333 | IDH2 IDH1 | Hemangiomatosis |
| HP:0009592 | 0.0114630974264 | 0.333333333333 | IDH2 IDH1 | Astrocytoma |
| HP:0100777 | 0.0114630974264 | 0.333333333333 | IDH2 IDH1 | Exostoses |
| HP:0011766 | 0.0114630974264 | 0.333333333333 | IDH2 IDH1 | Abnormality of the parathyroid morphology |
| HP:0100641 | 0.0114630974264 | 0.333333333333 | IDH2 IDH1 | Neoplasm of the adrenal cortex |
| HP:0100707 | 0.0128094019441 | 0.333333333333 | IDH2 IDH1 | Abnormality of the astrocytes |
| KEGG:01230 | 0.0153684049392 | 0.333333333333 | IDH2 IDH1 | Biosynthesis of amino acids |
| KEGG:04146 | 0.0171495874594 | 0.333333333333 | IDH2 IDH1 | Peroxisome |
| CORUM:6948 | 0.0249904952816 | 0.166666666667 | IDH2 | Isocitrate dehydrogenase [NADP], mitochondrial |
| CORUM:404 | 0.0249904952816 | 0.166666666667 | IDH1 | Isocitrate dehydrogenase [NADP], cytoplasmic |
| HP:0002893 | 0.0262553193116 | 0.333333333333 | IDH2 IDH1 | Pituitary adenoma |
| HP:0025032 | 0.0285785274048 | 0.833333333333 | AK2 IDH2 IDH1 UBQLN2 ACSF3 | Abnormality of digestive system physiology |
| HP:0100631 | 0.030358517586 | 0.333333333333 | IDH2 IDH1 | Neoplasm of the adrenal gland |
| KEGG:01100 | 0.0331288091988 | 0.666666666667 | AK2 IDH2 IDH1 ACSF3 | Metabolic pathways |
| HP:0100021 | 0.0394527338604 | 0.333333333333 | IDH2 IDH1 | Cerebral palsy |
| HP:0011750 | 0.0394527338604 | 0.333333333333 | IDH2 IDH1 | Neoplasm of the anterior pituitary |
| HP:0040277 | 0.0394527338604 | 0.333333333333 | IDH2 IDH1 | Neoplasm of the pituitary gland |
| KEGG:01200 | 0.039527830217 | 0.333333333333 | IDH2 IDH1 | Carbon metabolism |
| HP:0009733 | 0.0419110169922 | 0.333333333333 | IDH2 IDH1 | Glioma |
| HP:0003215 | 0.0497285764978 | 0.333333333333 | ACSF3 IDH2 | Dicarboxylic aciduria |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TXNDC17 | IDH2 | 0.937 | 0.85 | bioplex_WMM fraction |
| IDH2 | UBQLN2 | 0.914 | 0.838 | bioplex_WMM boldt fraction boldt_WMM |
| IDH1 | IDH2 | 0.733 | 0.738 | bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| IDH1 | TXNDC17 | 0.682 | 0.71 | bioplex_WMM fraction |
| IDH2 | AK2 | 0.66 | 0.697 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| ACSF3 | IDH2 | 0.5 | 0.621 | bioplex_WMM youn_WMM fraction |
| ACSF3 | UBQLN2 | 0.151 | 0.411 | fraction |
| IDH1 | UBQLN2 | 0.119 | 0.392 | bioplex_WMM fraction boldt_WMM |
| ACSF3 | TXNDC17 | 0.047 | 0.293 | fraction |
| TXNDC17 | AK2 | 0.025 | 0.218 | bioplex_WMM fraction |
| IDH1 | AK2 | 0.014 | 0.135 | bioplex_WMM Guru fraction boldt_WMM treiber_WMM |
| ACSF3 | AK2 | 0.007 | 0.002 | bioplex (ACSF3) |
| AK2 | UBQLN2 | 0.0 | 0.003 | bioplex_WMM boldt fraction boldt_WMM |
| TXNDC17 | UBQLN2 | 0.0 | 0.001 | bioplex_WMM fraction |
Images
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Complex HuMAP2_04319 has an average edge precision of 0.422 which is ranked 3090 out of all 6965 complexes.
Related Complexes