hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04323
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ARPC2 | Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) | UniProt NCBI |
| ARPC4 | Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) | UniProt NCBI |
| ARPC5 | Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) | UniProt NCBI |
| ACTR2 | Actin-related protein 2 (Actin-like protein 2) | UniProt NCBI |
| ACTR3 | Actin-related protein 3 (Actin-like protein 3) | UniProt NCBI |
| ARPC1B | Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) | UniProt NCBI |
| ARPC3 | Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) | UniProt NCBI |
| ARPC1A | Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) | UniProt NCBI |
| ARPC5L | Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005885 | 5.04290534095e-28 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | Arp2/3 protein complex |
| CORUM:27 | 4.61796517245e-23 | 0.777777777778 | ARPC4 ARPC1B ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Arp2/3 protein complex |
| GO:0034314 | 1.57568098831e-21 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | Arp2/3 complex-mediated actin nucleation |
| GO:0045010 | 1.01665349891e-20 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | actin nucleation |
| REAC:R-HSA-5663213 | 7.02770763273e-19 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | RHO GTPases Activate WASPs and WAVEs |
| REAC:R-HSA-3928662 | 1.83663655589e-18 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | EPHB-mediated forward signaling |
| GO:0030838 | 8.74528718008e-18 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | positive regulation of actin filament polymerization |
| REAC:R-HSA-2029482 | 6.6117820989e-17 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Regulation of actin dynamics for phagocytic cup formation |
| GO:0032273 | 3.95246808574e-16 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | positive regulation of protein polymerization |
| REAC:R-HSA-2029480 | 8.63227409748e-16 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Fcgamma receptor (FCGR) dependent phagocytosis |
| GO:0030833 | 8.72942520113e-16 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of actin filament polymerization |
| REAC:R-HSA-2682334 | 1.5795296652e-15 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | EPH-Ephrin signaling |
| GO:0008064 | 2.77085630874e-15 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of actin polymerization or depolymerization |
| GO:0030832 | 3.01064195084e-15 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of actin filament length |
| GO:0030041 | 4.50877396197e-15 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | actin filament polymerization |
| WP:WP2272 | 8.90543475524e-15 | 0.777777777778 | ARPC4 ARPC1B ARPC5L ARPC5 ARPC2 ARPC1A ARPC3 | Pathogenic Escherichia coli infection |
| GO:0008154 | 2.20832668403e-14 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | actin polymerization or depolymerization |
| GO:1902905 | 2.35889441249e-14 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | positive regulation of supramolecular fiber organization |
| GO:0051015 | 2.51851884641e-14 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | actin filament binding |
| GO:0032271 | 3.05656940476e-14 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of protein polymerization |
| KEGG:05131 | 3.52914377887e-14 | 0.777777777778 | ARPC4 ARPC1B ARPC5L ARPC5 ARPC2 ARPC1A ARPC3 | Shigellosis |
| KEGG:05132 | 4.93874394151e-14 | 0.777777777778 | ARPC4 ARPC1B ARPC5L ARPC5 ARPC2 ARPC1A ARPC3 | Salmonella infection |
| GO:0051495 | 6.37652323649e-14 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | positive regulation of cytoskeleton organization |
| KEGG:05100 | 9.24654473988e-14 | 0.777777777778 | ARPC4 ARPC1B ARPC5L ARPC5 ARPC2 ARPC1A ARPC3 | Bacterial invasion of epithelial cells |
| GO:0038096 | 1.26142094892e-13 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| GO:0038094 | 1.26142094892e-13 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Fc-gamma receptor signaling pathway |
| GO:0002433 | 1.26142094892e-13 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| GO:0110053 | 1.40248671882e-13 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of actin filament organization |
| GO:0048013 | 1.57309255491e-13 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | ephrin receptor signaling pathway |
| GO:0002431 | 1.57309255491e-13 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Fc receptor mediated stimulatory signaling pathway |
| GO:0031334 | 2.89485751156e-13 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | positive regulation of protein complex assembly |
| KEGG:04666 | 3.59630386511e-13 | 0.777777777778 | ARPC4 ARPC1B ARPC5L ARPC5 ARPC2 ARPC1A ARPC3 | Fc gamma R-mediated phagocytosis |
| GO:0051258 | 6.49489465482e-13 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | protein polymerization |
| GO:0032535 | 1.20129758284e-12 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of cellular component size |
| GO:0032956 | 2.60124591602e-12 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of actin cytoskeleton organization |
| GO:1902903 | 3.03593588653e-12 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of supramolecular fiber organization |
| GO:0003779 | 7.5419763116e-12 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | actin binding |
| GO:0032970 | 8.362403927e-12 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of actin filament-based process |
| GO:0090066 | 8.65298939164e-12 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of anatomical structure size |
| GO:0035861 | 1.12751783204e-11 | 0.777777777778 | ARPC4 ACTR3 ARPC5 ARPC2 ARPC3 ACTR2 ARPC1A | site of double-strand break |
| GO:0007015 | 1.72330087099e-11 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | actin filament organization |
| REAC:R-HSA-8856828 | 2.19326888233e-11 | 0.777777777778 | ARPC4 ACTR3 ARPC5 ARPC2 ARPC3 ACTR2 ARPC1A | Clathrin-mediated endocytosis |
| GO:0043254 | 3.56785860604e-11 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of protein complex assembly |
| KEGG:05130 | 5.36824980712e-11 | 0.777777777778 | ARPC4 ARPC1B ARPC5L ARPC5 ARPC2 ARPC1A ARPC3 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-195258 | 5.52560359036e-11 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | RHO GTPase Effectors |
| GO:0038093 | 7.34170911813e-11 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Fc receptor signaling pathway |
| KEGG:04810 | 7.92899642874e-11 | 0.777777777778 | ARPC4 ARPC1B ARPC5L ARPC5 ARPC2 ARPC1A ARPC3 | Regulation of actin cytoskeleton |
| GO:0090734 | 9.03387421086e-11 | 0.777777777778 | ARPC4 ACTR3 ARPC5 ARPC2 ARPC3 ACTR2 ARPC1A | site of DNA damage |
| GO:0044089 | 1.41104139472e-10 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | positive regulation of cellular component biogenesis |
| GO:0051493 | 2.40657145359e-10 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of cytoskeleton organization |
| GO:0015629 | 2.46387077392e-10 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | actin cytoskeleton |
| GO:0006909 | 2.8113645295e-10 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | phagocytosis |
| KEGG:04144 | 3.53856441302e-10 | 0.777777777778 | ARPC4 ARPC1B ARPC5L ARPC5 ARPC2 ARPC1A ARPC3 | Endocytosis |
| GO:0005200 | 4.13417561116e-10 | 0.777777777778 | ARPC4 ARPC1B ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | structural constituent of cytoskeleton |
| REAC:R-HSA-194315 | 7.91557982478e-10 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Signaling by Rho GTPases |
| GO:0010638 | 1.46794561477e-09 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | positive regulation of organelle organization |
| GO:0030036 | 2.43448404911e-09 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | actin cytoskeleton organization |
| GO:0097435 | 2.47919906226e-09 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | supramolecular fiber organization |
| REAC:R-HSA-422475 | 3.26651941119e-09 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Axon guidance |
| GO:0002429 | 6.62609840593e-09 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | immune response-activating cell surface receptor signaling pathway |
| GO:0030029 | 8.68736238395e-09 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | actin filament-based process |
| GO:0002768 | 1.18383944464e-08 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | immune response-regulating cell surface receptor signaling pathway |
| GO:0044087 | 3.16939176446e-08 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of cellular component biogenesis |
| GO:0008092 | 6.45235741927e-08 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | cytoskeletal protein binding |
| GO:0044877 | 1.3693404076e-07 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | protein-containing complex binding |
| GO:0002757 | 1.38141911675e-07 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | immune response-activating signal transduction |
| GO:0002764 | 2.10102101347e-07 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | immune response-regulating signaling pathway |
| GO:0051130 | 2.46027796896e-07 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | positive regulation of cellular component organization |
| REAC:R-HSA-168249 | 2.85312399642e-07 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Innate Immune System |
| GO:0034622 | 3.01982316681e-07 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | cellular protein-containing complex assembly |
| REAC:R-HSA-1266738 | 3.52172614621e-07 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Developmental Biology |
| GO:0002253 | 4.42046598641e-07 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | activation of immune response |
| GO:0033043 | 7.5893988611e-07 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of organelle organization |
| GO:0007169 | 8.07160157434e-07 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | transmembrane receptor protein tyrosine kinase signaling pathway |
| REAC:R-HSA-199991 | 8.88804404405e-07 | 0.777777777778 | ARPC4 ACTR3 ARPC5 ARPC2 ARPC3 ACTR2 ARPC1A | Membrane Trafficking |
| REAC:R-HSA-5653656 | 1.29101301448e-06 | 0.777777777778 | ARPC4 ACTR3 ARPC5 ARPC2 ARPC3 ACTR2 ARPC1A | Vesicle-mediated transport |
| GO:0050778 | 1.75327742905e-06 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | positive regulation of immune response |
| GO:0007010 | 1.76619813914e-06 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | cytoskeleton organization |
| GO:0044430 | 6.40285487113e-06 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | cytoskeletal part |
| GO:0005925 | 6.98248658162e-06 | 0.777777777778 | ARPC5L ARPC1B ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | focal adhesion |
| GO:0005924 | 7.26406272053e-06 | 0.777777777778 | ARPC5L ARPC1B ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | cell-substrate adherens junction |
| GO:0030055 | 8.01085041987e-06 | 0.777777777778 | ARPC5L ARPC1B ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | cell-substrate junction |
| GO:0050776 | 1.09477686875e-05 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | regulation of immune response |
| GO:0007167 | 1.10718395243e-05 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | enzyme linked receptor protein signaling pathway |
| GO:0002684 | 1.23817421607e-05 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | positive regulation of immune system process |
| GO:0065003 | 2.27112016477e-05 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | protein-containing complex assembly |
| GO:0005912 | 4.11374402531e-05 | 0.777777777778 | ARPC5L ARPC1B ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | adherens junction |
| GO:0005856 | 4.45418003239e-05 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | cytoskeleton |
| GO:0002252 | 4.57481639606e-05 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | immune effector process |
| GO:0070161 | 4.8595981113e-05 | 0.777777777778 | ARPC5L ARPC1B ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | anchoring junction |
| GO:0005198 | 5.88738674001e-05 | 0.777777777778 | ARPC4 ARPC1B ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | structural molecule activity |
| REAC:R-HSA-168256 | 5.91085572158e-05 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Immune System |
| HPA:028010_23 | 0.000111948262754 | 0.555555555556 | ARPC2 ACTR2 ACTR3 ARPC3 ARPC1B | lymph node; germinal center cells[Approved,High] |
| GO:0043933 | 0.000124602814544 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | protein-containing complex subunit organization |
| REAC:R-HSA-162582 | 0.000143548616456 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Signal Transduction |
| GO:0051128 | 0.00016306187717 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of cellular component organization |
| GO:0002682 | 0.000200958578249 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | regulation of immune system process |
| GO:0070358 | 0.000266683990267 | 0.333333333333 | ARPC2 ACTR3 ARPC3 | actin polymerization-dependent cell motility |
| GO:0061024 | 0.000339049144173 | 0.777777777778 | ARPC4 ACTR3 ARPC5 ARPC2 ARPC3 ACTR2 ARPC1A | membrane organization |
| GO:0070062 | 0.000481319254417 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | extracellular exosome |
| HPA:056010_23 | 0.000516341645432 | 0.555555555556 | ARPC2 ACTR2 ACTR3 ARPC3 ARPC1B | tonsil; germinal center cells[Approved,High] |
| GO:1903561 | 0.000521168779507 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | extracellular vesicle |
| GO:0043230 | 0.000528497610179 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | extracellular organelle |
| HPA:028020_23 | 0.000710591039307 | 0.555555555556 | ARPC2 ACTR2 ACTR3 ARPC3 ARPC1B | lymph node; non-germinal center cells[Approved,High] |
| GO:0030054 | 0.000715760481065 | 0.777777777778 | ARPC5L ARPC1B ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | cell junction |
| HPA:056020_23 | 0.000913082675172 | 0.555555555556 | ARPC2 ACTR2 ACTR3 ARPC3 ARPC1B | tonsil; non-germinal center cells[Approved,High] |
| HPA:002020_21 | 0.00113220566708 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | appendix; lymphoid tissue[Approved,Low] |
| HPA:050010_21 | 0.00161785531572 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | spleen; cells in red pulp[Approved,Low] |
| GO:0006955 | 0.00200840362112 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | immune response |
| GO:0022607 | 0.00241624575324 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | cellular component assembly |
| TF:M09606_1 | 0.00449652638983 | 0.888888888889 | ARPC4 ARPC1B ARPC5L ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | Factor: nerf; motif: NRRNSCGGAAGNRNNNN; match class: 1 |
| GO:0044085 | 0.00493151992766 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | cellular component biogenesis |
| HPA:056010_21 | 0.00524526616115 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | tonsil; germinal center cells[Approved,Low] |
| GO:0016192 | 0.00544655604972 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | vesicle-mediated transport |
| WP:000000 | 0.00566194757866 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | WIKIPATHWAYS |
| GO:0005615 | 0.00613702299981 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | extracellular space |
| GO:0048584 | 0.00656700235961 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | positive regulation of response to stimulus |
| HPA:022020_22 | 0.00850298959146 | 0.777777777778 | ARPC5L ACTR3 ARPC5 ARPC2 ARPC1A ACTR2 ARPC3 | hippocampus; neuronal cells[Approved,Medium] |
| GO:0065008 | 0.00865667784629 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | regulation of biological quality |
| HPA:003010_21 | 0.00946416765647 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | bone marrow; hematopoietic cells[Approved,Low] |
| HPA:035010_20 | 0.00993041433148 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | placenta; decidual cells[Approved,Not detected] |
| GO:0044421 | 0.0101467036581 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | extracellular region part |
| HPA:006010_21 | 0.0108072292665 | 0.777777777778 | ARPC5L ACTR3 ARPC5 ARPC2 ARPC1A ACTR2 ARPC3 | caudate; glial cells[Approved,Low] |
| HPA:007030_22 | 0.0138160555709 | 0.666666666667 | ARPC5L ARPC5 ARPC2 ARPC1A ACTR2 ARPC3 | cerebellum; cells in molecular layer[Approved,Medium] |
| HPA:048040_20 | 0.0154326378725 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | soft tissue 2; peripheral nerve[Approved,Not detected] |
| KEGG:00000 | 0.0200811167769 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | KEGG root term |
| HPA:007010_22 | 0.0201312768903 | 0.777777777778 | ARPC5L ACTR3 ARPC5 ARPC2 ARPC1A ACTR2 ARPC3 | cerebellum; Purkinje cells[Approved,Medium] |
| HPA:035010_21 | 0.0202907927613 | 0.777777777778 | ARPC5L ARPC1B ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | placenta; decidual cells[Approved,Low] |
| HPA:004020_21 | 0.0207309491158 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | breast; glandular cells[Approved,Low] |
| GO:0005576 | 0.0215129649219 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | extracellular region |
| HPA:035020_21 | 0.0223237027347 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | placenta; trophoblastic cells[Approved,Low] |
| GO:0031982 | 0.0258329558349 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | vesicle |
| HPA:008030_22 | 0.0285147570384 | 0.777777777778 | ARPC5L ACTR3 ARPC5 ARPC2 ARPC1A ACTR2 ARPC3 | cerebral cortex; neuronal cells[Approved,Medium] |
| HPA:029010_21 | 0.0299757807247 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | nasopharynx; respiratory epithelial cells[Approved,Low] |
| GO:0002376 | 0.0312712180656 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | immune system process |
| CORUM:0000000 | 0.0319384059855 | 0.777777777778 | ARPC4 ARPC1B ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | CORUM root |
| GO:0006996 | 0.032979143004 | 1.0 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ARPC5L ACTR3 | organelle organization |
| HPA:004020_22 | 0.0332116607693 | 0.777777777778 | ARPC5L ACTR3 ARPC5 ARPC2 ARPC1A ACTR2 ARPC3 | breast; glandular cells[Approved,Medium] |
| GO:0007166 | 0.0337820230382 | 0.888888888889 | ARPC4 ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | cell surface receptor signaling pathway |
| HPA:027020_21 | 0.0339445035812 | 0.777777777778 | ARPC5L ACTR3 ARPC5 ARPC2 ARPC1A ACTR2 ARPC3 | lung; pneumocytes[Approved,Low] |
| HPA:015010_21 | 0.034618594898 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | epididymis; glandular cells[Approved,Low] |
| HPA:018010_21 | 0.0354952126257 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | fallopian tube; glandular cells[Approved,Low] |
| HPA:057010_21 | 0.0357687654703 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | urinary bladder; urothelial cells[Approved,Low] |
| HPA:024010_21 | 0.0362249050944 | 0.777777777778 | ARPC5L ACTR3 ARPC5 ARPC2 ARPC1A ACTR2 ARPC3 | kidney; cells in glomeruli[Approved,Low] |
| WP:WP3680 | 0.0372407964212 | 0.222222222222 | ACTR2 ACTR3 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| HPA:053020_21 | 0.0374485996073 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | testis; cells in seminiferous ducts[Approved,Low] |
| GO:0044427 | 0.0384546907947 | 0.777777777778 | ARPC4 ACTR3 ARPC5 ARPC2 ARPC3 ACTR2 ARPC1A | chromosomal part |
| HPA:053010_21 | 0.0399446734199 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | testis; Leydig cells[Approved,Low] |
| HPA:035010_22 | 0.0416215728797 | 0.666666666667 | ARPC5L ACTR3 ARPC5 ARPC2 ARPC3 ACTR2 | placenta; decidual cells[Approved,Medium] |
| HPA:052010_21 | 0.0417918431829 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | stomach 2; glandular cells[Approved,Low] |
| HPA:051010_21 | 0.0438756345074 | 0.888888888889 | ARPC5L ARPC1B ARPC1A ARPC5 ARPC2 ARPC3 ACTR2 ACTR3 | stomach 1; glandular cells[Approved,Low] |
| GO:0005694 | 0.049270844601 | 0.777777777778 | ARPC4 ACTR3 ARPC5 ARPC2 ARPC3 ACTR2 ARPC1A | chromosome |
| CORUM:6725 | 0.0499262710315 | 0.111111111111 | ACTR3 | ARP3-WHAMM complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ACTR2 | ARPC1B | 1.0 | 0.949 | hein_WMM bioplex (ARPC1B) bioplex_WMM Guru hein (ACTR2) Malo fraction treiber_WMM |
| ACTR3 | ARPC3 | 1.0 | 0.949 | hein_WMM bioplex (ACTR3,ARPC3) bioplex_WMM boldt gupta_WMM fraction boldt_WMM |
| ACTR2 | ARPC3 | 1.0 | 0.949 | hein_WMM bioplex (ARPC3) bioplex_WMM Guru hein (ACTR2) gupta_WMM fraction |
| ARPC4 | ACTR3 | 1.0 | 0.949 | hein_WMM bioplex (ACTR3) bioplex_WMM boldt gupta_WMM fraction boldt_WMM |
| ACTR2 | ARPC2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru hein (ACTR2) gupta_WMM fraction treiber_WMM |
| ACTR3 | ARPC2 | 1.0 | 0.949 | hein_WMM bioplex (ACTR3) bioplex_WMM gupta_WMM fraction |
| ARPC1B | ARPC2 | 1.0 | 0.949 | hein_WMM bioplex (ARPC1B) bioplex_WMM Guru fraction treiber_WMM |
| ACTR2 | ARPC4 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (ACTR2) gupta_WMM fraction treiber_WMM |
| ARPC5 | ARPC2 | 1.0 | 0.949 | hein_WMM bioplex (ARPC5) bioplex_WMM Guru fraction |
| ARPC3 | ARPC2 | 1.0 | 0.949 | hein_WMM bioplex (ARPC3) bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| ACTR2 | ARPC1A | 1.0 | 0.949 | hein_WMM bioplex (ARPC1A) bioplex_WMM Guru hein (ACTR2) gupta_WMM fraction |
| ARPC4 | ARPC2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| ARPC2 | ARPC1A | 1.0 | 0.949 | hein_WMM bioplex (ARPC1A) bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| ARPC4 | ARPC1B | 1.0 | 0.949 | hein_WMM bioplex (ARPC1B) bioplex_WMM Guru fraction boldt_WMM treiber_WMM |
| ARPC3 | ARPC5L | 1.0 | 0.949 | hein_WMM bioplex (ARPC3) bioplex_WMM Guru fraction |
| ARPC4 | ARPC5 | 1.0 | 0.949 | hein_WMM bioplex (ARPC5) bioplex_WMM Guru fraction |
| ARPC5 | ACTR3 | 1.0 | 0.949 | hein_WMM bioplex (ACTR3,ARPC5) bioplex_WMM fraction |
| ACTR3 | ARPC1B | 1.0 | 0.949 | hein_WMM bioplex (ACTR3,ARPC1B) bioplex_WMM Malo fraction boldt_WMM treiber_WMM |
| ARPC5 | ARPC3 | 1.0 | 0.949 | hein_WMM bioplex (ARPC3,ARPC5) bioplex_WMM Guru fraction |
| ARPC4 | ARPC1A | 1.0 | 0.949 | hein_WMM bioplex (ARPC1A) bioplex_WMM Guru gupta_WMM fraction |
| ARPC4 | ARPC3 | 1.0 | 0.949 | hein_WMM bioplex (ARPC3) bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| ARPC5 | ARPC1B | 1.0 | 0.949 | hein_WMM bioplex (ARPC1B,ARPC5) bioplex_WMM Guru fraction |
| ACTR2 | ACTR3 | 1.0 | 0.949 | hein_WMM bioplex (ACTR3) bioplex_WMM hein (ACTR2) Malo gupta_WMM fraction treiber_WMM |
| ACTR3 | ARPC5L | 1.0 | 0.949 | hein_WMM bioplex (ACTR3) bioplex_WMM fraction |
| ARPC2 | ARPC5L | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru fraction |
| ARPC1B | ARPC5L | 1.0 | 0.949 | hein_WMM bioplex (ARPC1B) bioplex_WMM Guru fraction |
| ACTR3 | ARPC1A | 0.999 | 0.949 | hein_WMM bioplex (ACTR3,ARPC1A) bioplex_WMM gupta_WMM fraction |
| ARPC3 | ARPC1A | 0.999 | 0.949 | hein_WMM bioplex (ARPC1A,ARPC3) bioplex_WMM Guru gupta_WMM fraction |
| ACTR2 | ARPC5L | 0.999 | 0.946 | hein_WMM bioplex_WMM Guru hein (ACTR2) fraction |
| ARPC1B | ARPC3 | 0.999 | 0.945 | hein_WMM bioplex (ARPC1B,ARPC3) bioplex_WMM Guru fraction |
| ARPC5 | ARPC1A | 0.995 | 0.924 | hein_WMM bioplex (ARPC1A,ARPC5) bioplex_WMM Guru fraction |
| ARPC1A | ARPC5L | 0.995 | 0.924 | hein_WMM bioplex (ARPC1A) bioplex_WMM Guru fraction |
| ACTR2 | ARPC5 | 0.969 | 0.88 | hein_WMM bioplex (ARPC5) bioplex_WMM Guru hein (ACTR2) fraction |
| ARPC4 | ARPC5L | 0.962 | 0.87 | hein_WMM bioplex_WMM Guru fraction |
| ARPC5 | ARPC5L | 0.014 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| ARPC1B | ARPC1A | 0.0 | 0.01 | hein_WMM bioplex_WMM fraction |
Images
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Complex HuMAP2_04323 has an average edge precision of 0.895 which is ranked 600 out of all 6965 complexes.
Related Complexes