hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04327
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATP6AP2 | Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adaptor) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) | UniProt NCBI |
| ATP6AP1 | V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1) | UniProt NCBI |
| VMA21 | Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein) | UniProt NCBI |
| TMEM199 | Transmembrane protein 199 | UniProt NCBI |
| CCDC115 | Coiled-coil domain-containing protein 115 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0033176 | 4.7240495605e-07 | 0.8 | TMEM199 CCDC115 ATP6AP1 ATP6AP2 | proton-transporting V-type ATPase complex |
| GO:0016469 | 1.2328136433e-05 | 0.8 | TMEM199 CCDC115 ATP6AP1 ATP6AP2 | proton-transporting two-sector ATPase complex |
| GO:0036296 | 0.000149729915117 | 0.6 | TMEM199 ATP6AP1 CCDC115 | response to increased oxygen levels |
| GO:0036295 | 0.000149729915117 | 0.6 | TMEM199 ATP6AP1 CCDC115 | cellular response to increased oxygen levels |
| GO:0016471 | 0.000616695699567 | 0.6 | TMEM199 ATP6AP2 CCDC115 | vacuolar proton-transporting V-type ATPase complex |
| HP:0010837 | 0.000696775152219 | 0.4 | CCDC115 TMEM199 | Decreased serum ceruloplasmin |
| WP:WP623 | 0.00492385173449 | 0.4 | ATP6AP1 ATP6AP2 | Oxidative phosphorylation |
| HP:0001419 | 0.00529202687437 | 0.6 | VMA21 ATP6AP1 ATP6AP2 | X-linked recessive inheritance |
| HP:0003141 | 0.00709565752293 | 0.4 | CCDC115 TMEM199 | Increased LDL cholesterol concentration |
| HP:0010980 | 0.00973521215689 | 0.4 | CCDC115 TMEM199 | Hyperlipoproteinemia |
| HP:0002910 | 0.0103373169418 | 0.6 | TMEM199 ATP6AP1 CCDC115 | Elevated hepatic transaminase |
| GO:0045851 | 0.0103850554114 | 0.6 | TMEM199 ATP6AP1 CCDC115 | pH reduction |
| HP:0001417 | 0.0135562849022 | 0.6 | VMA21 ATP6AP1 ATP6AP2 | X-linked inheritance |
| HP:0010985 | 0.0143516120275 | 0.6 | VMA21 ATP6AP1 ATP6AP2 | Gonosomal inheritance |
| HP:0031886 | 0.0150562782431 | 0.4 | CCDC115 TMEM199 | Abnormal LDL cholesterol concentration |
| GO:0006879 | 0.0177162705742 | 0.6 | TMEM199 ATP6AP1 CCDC115 | cellular iron ion homeostasis |
| HP:0006579 | 0.0215275853758 | 0.4 | ATP6AP1 CCDC115 | Prolonged neonatal jaundice |
| HP:0012759 | 0.0220185590621 | 1.0 | VMA21 CCDC115 ATP6AP1 TMEM199 ATP6AP2 | Neurodevelopmental abnormality |
| GO:0055072 | 0.0237016209836 | 0.6 | TMEM199 ATP6AP1 CCDC115 | iron ion homeostasis |
| HP:0010979 | 0.0244376541782 | 0.4 | CCDC115 TMEM199 | Abnormality of lipoprotein cholesterol concentration |
| HP:0012345 | 0.0244376541782 | 0.4 | CCDC115 TMEM199 | Abnormal glycosylation |
| HP:0003124 | 0.0325153883173 | 0.4 | CCDC115 TMEM199 | Hypercholesterolemia |
| GO:0030641 | 0.0472676873043 | 0.6 | TMEM199 ATP6AP1 CCDC115 | regulation of cellular pH |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATP6AP2 | ATP6AP1 | 1.0 | 0.949 | hein_WMM bioplex (ATP6AP2) bioplex_WMM youn_WMM hein (ATP6AP2) gupta_WMM |
| ATP6AP2 | CCDC115 | 1.0 | 0.949 | hein_WMM bioplex (ATP6AP2) bioplex_WMM youn_WMM hein (ATP6AP2) gupta_WMM |
| ATP6AP2 | VMA21 | 0.998 | 0.941 | bioplex (ATP6AP2) bioplex_WMM youn_WMM gupta_WMM |
| TMEM199 | ATP6AP2 | 0.752 | 0.745 | bioplex (ATP6AP2,TMEM199) bioplex_WMM youn_WMM gupta_WMM |
| TMEM199 | CCDC115 | 0.325 | 0.514 | hein_WMM bioplex (TMEM199) bioplex_WMM youn_WMM gupta_WMM |
| TMEM199 | VMA21 | 0.301 | 0.496 | bioplex (TMEM199) bioplex_WMM youn_WMM gupta_WMM |
| TMEM199 | ATP6AP1 | 0.094 | 0.356 | hein_WMM bioplex (TMEM199) bioplex_WMM youn_WMM gupta_WMM |
| ATP6AP1 | CCDC115 | 0.029 | 0.232 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| VMA21 | CCDC115 | 0.02 | 0.185 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ATP6AP1 | VMA21 | 0.019 | 0.185 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_04327 has an average edge precision of 0.555 which is ranked 2166 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ATP6AP2 | HuMAP2_00515 HuMAP2_01018 HuMAP2_01270 HuMAP2_04327 HuMAP2_05361 HuMAP2_05879 HuMAP2_06410 |
| ATP6AP1 | HuMAP2_00515 HuMAP2_01018 HuMAP2_01270 HuMAP2_04327 HuMAP2_05361 |
| VMA21 | HuMAP2_00515 HuMAP2_01018 HuMAP2_01270 HuMAP2_04327 |
| TMEM199 | HuMAP2_00515 HuMAP2_01018 HuMAP2_01270 HuMAP2_04327 |
| CCDC115 | HuMAP2_00515 HuMAP2_01018 HuMAP2_01270 HuMAP2_04327 |