hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04331
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SMAD2 | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | UniProt NCBI |
| SMAD3 | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3311021 | 5.02777038712e-06 | 1.0 | SMAD3 SMAD2 | SMAD4 MH2 Domain Mutants in Cancer |
| CORUM:2834 | 5.02777038712e-06 | 1.0 | SMAD3 SMAD2 | SMAD4-SMAD2-SMAD3 complex |
| REAC:R-HSA-3304347 | 5.02777038712e-06 | 1.0 | SMAD3 SMAD2 | Loss of Function of SMAD4 in Cancer |
| REAC:R-HSA-3315487 | 5.02777038712e-06 | 1.0 | SMAD3 SMAD2 | SMAD2/3 MH2 Domain Mutants in Cancer |
| CORUM:2830 | 5.02777038712e-06 | 1.0 | SMAD3 SMAD2 | TIF1gamma-SMAD2-SMAD3 complex |
| REAC:R-HSA-3304356 | 1.00555407742e-05 | 1.0 | SMAD3 SMAD2 | SMAD2/3 Phosphorylation Motif Mutants in Cancer |
| REAC:R-HSA-3656532 | 1.00555407742e-05 | 1.0 | SMAD3 SMAD2 | TGFBR1 KD Mutants in Cancer |
| CORUM:1827 | 1.00555407742e-05 | 1.0 | SMAD3 SMAD2 | PML-SMAD2/3-SARA complex |
| REAC:R-HSA-3304349 | 1.67592346237e-05 | 1.0 | SMAD3 SMAD2 | Loss of Function of SMAD2/3 in Cancer |
| REAC:R-HSA-3656534 | 1.67592346237e-05 | 1.0 | SMAD3 SMAD2 | Loss of Function of TGFBR1 in Cancer |
| REAC:R-HSA-3304351 | 2.51388519356e-05 | 1.0 | SMAD3 SMAD2 | Signaling by TGF-beta Receptor Complex in Cancer |
| WP:WP3874 | 3.91210398304e-05 | 1.0 | SMAD3 SMAD2 | Canonical and Non-Canonical TGF-B signaling |
| WP:WP3859 | 3.91210398304e-05 | 1.0 | SMAD3 SMAD2 | TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition |
| REAC:R-HSA-1502540 | 6.03332446455e-05 | 1.0 | SMAD3 SMAD2 | Signaling by Activin |
| WP:WP4331 | 7.07904530264e-05 | 1.0 | SMAD3 SMAD2 | Neovascularisation processes |
| CORUM:2829 | 7.54165558069e-05 | 1.0 | SMAD3 SMAD2 | RSmad complex |
| WP:WP3668 | 0.000111774399515 | 1.0 | SMAD3 SMAD2 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
| WP:WP2870 | 0.000111774399515 | 1.0 | SMAD3 SMAD2 | Extracellular vesicle-mediated signaling in recipient cells |
| WP:WP3850 | 0.000121088932808 | 1.0 | SMAD3 SMAD2 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| KEGG:05321 | 0.000138019076752 | 1.0 | SMAD3 SMAD2 | Inflammatory bowel disease (IBD) |
| REAC:R-HSA-1181150 | 0.000201110815485 | 1.0 | SMAD3 SMAD2 | Signaling by NODAL |
| REAC:R-HSA-9617828 | 0.000227925590883 | 1.0 | SMAD3 SMAD2 | FOXO-mediated transcription of cell cycle genes |
| WP:WP1971 | 0.000336440942541 | 1.0 | SMAD3 SMAD2 | Integrated Cancer Pathway |
| REAC:R-HSA-2173788 | 0.000351943927099 | 1.0 | SMAD3 SMAD2 | Downregulation of TGF-beta receptor signaling |
| WP:WP560 | 0.000352461939805 | 1.0 | SMAD3 SMAD2 | TGF-beta Receptor Signaling |
| WP:WP4535 | 0.000352461939805 | 1.0 | SMAD3 SMAD2 | Envelope proteins and their potential roles in EDMD physiopathology |
| KEGG:05212 | 0.000362555397177 | 1.0 | SMAD3 SMAD2 | Pancreatic cancer |
| REAC:R-HSA-9615017 | 0.000424008635981 | 1.0 | SMAD3 SMAD2 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
| REAC:R-HSA-2173795 | 0.000424008635981 | 1.0 | SMAD3 SMAD2 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| KEGG:04350 | 0.000438130325039 | 1.0 | SMAD3 SMAD2 | TGF-beta signaling pathway |
| GO:0071144 | 0.000450823411379 | 1.0 | SMAD3 SMAD2 | heteromeric SMAD protein complex |
| KEGG:05210 | 0.000484525744074 | 1.0 | SMAD3 SMAD2 | Colorectal cancer |
| KEGG:04659 | 0.000533255523815 | 1.0 | SMAD3 SMAD2 | Th17 cell differentiation |
| REAC:R-HSA-2173789 | 0.000588249135293 | 1.0 | SMAD3 SMAD2 | TGF-beta receptor signaling activates SMADs |
| KEGG:04933 | 0.000597450443235 | 1.0 | SMAD3 SMAD2 | AGE-RAGE signaling pathway in diabetic complications |
| WP:WP2324 | 0.000774969169973 | 1.0 | SMAD3 SMAD2 | AGE/RAGE pathway |
| REAC:R-HSA-2173796 | 0.000779304410004 | 1.0 | SMAD3 SMAD2 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| WP:WP4216 | 0.000925864609319 | 1.0 | SMAD3 SMAD2 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:04110 | 0.00104170846513 | 1.0 | SMAD3 SMAD2 | Cell cycle |
| KEGG:04550 | 0.00109466927365 | 1.0 | SMAD3 SMAD2 | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04371 | 0.00111261467158 | 1.0 | SMAD3 SMAD2 | Apelin signaling pathway |
| KEGG:05226 | 0.00124231758831 | 1.0 | SMAD3 SMAD2 | Gastric cancer |
| WP:WP4263 | 0.00126789427184 | 1.0 | SMAD3 SMAD2 | Pancreatic adenocarcinoma pathway |
| WP:WP4540 | 0.00139382676196 | 1.0 | SMAD3 SMAD2 | Pathways Regulating Hippo Signaling |
| KEGG:04390 | 0.00146058031434 | 1.0 | SMAD3 SMAD2 | Hippo signaling pathway |
| REAC:R-HSA-2173793 | 0.00151335888652 | 1.0 | SMAD3 SMAD2 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| KEGG:04218 | 0.00152317036077 | 1.0 | SMAD3 SMAD2 | Cellular senescence |
| KEGG:05225 | 0.00183261905189 | 1.0 | SMAD3 SMAD2 | Hepatocellular carcinoma |
| WP:WP179 | 0.00248511748256 | 1.0 | SMAD3 SMAD2 | Cell Cycle |
| REAC:R-HSA-9614085 | 0.00277030148331 | 1.0 | SMAD3 SMAD2 | FOXO-mediated transcription |
| KEGG:05166 | 0.00281669798708 | 1.0 | SMAD3 SMAD2 | Human T-cell leukemia virus 1 infection |
| WP:WP366 | 0.00284130523568 | 1.0 | SMAD3 SMAD2 | TGF-beta Signaling Pathway |
| WP:WP2853 | 0.00284130523568 | 1.0 | SMAD3 SMAD2 | Endoderm Differentiation |
| WP:WP2857 | 0.00307603147466 | 1.0 | SMAD3 SMAD2 | Mesodermal Commitment Pathway |
| WP:WP4239 | 0.00336999814539 | 1.0 | SMAD3 SMAD2 | Epithelial to mesenchymal transition in colorectal cancer |
| REAC:R-HSA-170834 | 0.00381775364729 | 1.0 | SMAD3 SMAD2 | Signaling by TGF-beta Receptor Complex |
| KEGG:04144 | 0.00387576825996 | 1.0 | SMAD3 SMAD2 | Endocytosis |
| WP:WP4666 | 0.00388974910314 | 1.0 | SMAD3 SMAD2 | Hepatitis B infection |
| GO:0030618 | 0.00450823411379 | 1.0 | SMAD3 SMAD2 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
| MIRNA:hsa-miR-323a-3p | 0.00600464194312 | 1.0 | SMAD3 SMAD2 | hsa-miR-323a-3p |
| REAC:R-HSA-9006936 | 0.00656291627866 | 1.0 | SMAD3 SMAD2 | Signaling by TGF-beta family members |
| GO:0070878 | 0.00946729163895 | 1.0 | SMAD3 SMAD2 | primary miRNA binding |
| GO:0070410 | 0.00946729163895 | 1.0 | SMAD3 SMAD2 | co-SMAD binding |
| GO:0071141 | 0.00946729163895 | 1.0 | SMAD3 SMAD2 | SMAD protein complex |
| GO:0007183 | 0.0126230555186 | 1.0 | SMAD3 SMAD2 | SMAD protein complex assembly |
| GO:0005072 | 0.0126230555186 | 1.0 | SMAD3 SMAD2 | transforming growth factor beta receptor, cytoplasmic mediator activity |
| KEGG:05200 | 0.0157394270613 | 1.0 | SMAD3 SMAD2 | Pathways in cancer |
| GO:0038092 | 0.0162296428096 | 1.0 | SMAD3 SMAD2 | nodal signaling pathway |
| GO:0031053 | 0.0162296428096 | 1.0 | SMAD3 SMAD2 | primary miRNA processing |
| CORUM:3039 | 0.0249595281251 | 0.5 | SMAD2 | SMAD2-FAST1 complex |
| MIRNA:hsa-miR-200a-3p | 0.0260472731237 | 1.0 | SMAD3 SMAD2 | hsa-miR-200a-3p |
| REAC:R-HSA-5689880 | 0.0307297326061 | 1.0 | SMAD3 SMAD2 | Ub-specific processing proteases |
| WP:WP3674 | 0.0443803979089 | 0.5 | SMAD2 | Tgif disruption of Shh signaling |
| HP:0011645 | 0.0497341708567 | 0.5 | SMAD3 | Dilatation of the sinus of Valsalva |
| HP:0006687 | 0.0497341708567 | 0.5 | SMAD3 | Aortic tortuosity |
| CORUM:2813 | 0.0499173803268 | 0.5 | SMAD3 | BRCA1-SMAD3 complex |
| CORUM:2968 | 0.0499173803268 | 0.5 | SMAD3 | Axin-SMAD3 complex |
| CORUM:6513 | 0.0499173803268 | 0.5 | SMAD2 | MAN1-SMAD2 complex |
| CORUM:3199 | 0.0499173803268 | 0.5 | SMAD3 | SKI-SMAD3 complex |
| CORUM:3729 | 0.0499173803268 | 0.5 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3733 | 0.0499173803268 | 0.5 | SMAD3 | SKI-SMAD3 complex |
| CORUM:3749 | 0.0499173803268 | 0.5 | SMAD2 | CREBBP-SMAD2 hexameric complex |
| CORUM:3750 | 0.0499173803268 | 0.5 | SMAD3 | CREBBP-SMAD3 hexameric complex |
| CORUM:3038 | 0.0499173803268 | 0.5 | SMAD2 | SMAD2-SMAD4-FAST1 complex |
| CORUM:3198 | 0.0499173803268 | 0.5 | SMAD2 | SKI-SMAD2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMAD3 | SMAD2 | 1.0 | 0.949 | bioplex (SMAD3) bioplex_WMM |
Images
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Complex HuMAP2_04331 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SMAD2 | HuMAP2_04331 HuMAP2_04646 HuMAP2_05074 HuMAP2_05149 HuMAP2_06844 |
| SMAD3 | HuMAP2_04331 HuMAP2_04646 HuMAP2_05074 HuMAP2_05149 HuMAP2_06844 |