hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04333
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BMI1 | Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51) | UniProt NCBI |
| PHC2 | Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2) | UniProt NCBI |
| PHC3 | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | UniProt NCBI |
| CBX7 | Chromobox protein homolog 7 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035102 | 3.32999412455e-08 | 1.0 | PHC3 CBX7 BMI1 PHC2 | PRC1 complex |
| CORUM:115 | 1.11368231542e-07 | 0.75 | PHC3 BMI1 PHC2 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| CORUM:116 | 1.48483493479e-07 | 0.75 | PHC3 BMI1 PHC2 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| REAC:R-HSA-4655427 | 6.14088879325e-07 | 0.75 | PHC3 BMI1 PHC2 | SUMOylation of DNA methylation proteins |
| GO:0000152 | 2.73059518213e-06 | 1.0 | PHC3 CBX7 BMI1 PHC2 | nuclear ubiquitin ligase complex |
| GO:0031519 | 3.98098967922e-06 | 1.0 | PHC3 CBX7 BMI1 PHC2 | PcG protein complex |
| REAC:R-HSA-8939243 | 9.62627312117e-06 | 0.75 | PHC3 BMI1 PHC2 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| REAC:R-HSA-3899300 | 1.33177010906e-05 | 0.75 | PHC3 BMI1 PHC2 | SUMOylation of transcription cofactors |
| CORUM:5518 | 1.50819606993e-05 | 0.5 | BMI1 PHC2 | BMI1-HPH1-HPH2 complex |
| REAC:R-HSA-4570464 | 1.54728521392e-05 | 0.75 | PHC3 BMI1 PHC2 | SUMOylation of RNA binding proteins |
| CORUM:1462 | 3.01612206104e-05 | 0.5 | BMI1 PHC2 | hPRC1L complex |
| REAC:R-HSA-8943724 | 3.94070508018e-05 | 0.75 | PHC3 BMI1 PHC2 | Regulation of PTEN gene transcription |
| REAC:R-HSA-4551638 | 5.88039824914e-05 | 0.75 | PHC3 BMI1 PHC2 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-3108214 | 7.69213089466e-05 | 0.75 | PHC3 BMI1 PHC2 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-2559580 | 0.000396320737366 | 0.75 | PHC3 BMI1 PHC2 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-6807070 | 0.000537928298347 | 0.75 | PHC3 BMI1 PHC2 | PTEN Regulation |
| REAC:R-HSA-3108232 | 0.0010027366871 | 0.75 | PHC3 BMI1 PHC2 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.00111581489513 | 0.75 | PHC3 BMI1 PHC2 | SUMOylation |
| REAC:R-HSA-2559583 | 0.00145806857207 | 0.75 | PHC3 BMI1 PHC2 | Cellular Senescence |
| REAC:R-HSA-8878171 | 0.00230643324807 | 0.75 | PHC3 BMI1 PHC2 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-1257604 | 0.00250140055192 | 0.75 | PHC3 BMI1 PHC2 | PIP3 activates AKT signaling |
| REAC:R-HSA-9006925 | 0.00399488218563 | 0.75 | PHC3 BMI1 PHC2 | Intracellular signaling by second messengers |
| GO:0000151 | 0.0043315821947 | 1.0 | PHC3 CBX7 BMI1 PHC2 | ubiquitin ligase complex |
| REAC:R-HSA-8953750 | 0.00562500866147 | 0.5 | PHC3 BMI1 | Transcriptional Regulation by E2F6 |
| REAC:R-HSA-2262752 | 0.0147563350021 | 0.75 | PHC3 BMI1 PHC2 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.0253615474256 | 0.75 | PHC3 BMI1 PHC2 | Cellular responses to external stimuli |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BMI1 | CBX7 | 0.995 | 0.923 | hein_WMM bioplex (CBX7) bioplex_WMM hein (CBX7) |
| CBX7 | PHC2 | 0.946 | 0.857 | hein_WMM bioplex (CBX7) bioplex_WMM hein (CBX7) |
| CBX7 | PHC3 | 0.833 | 0.78 | hein_WMM bioplex (CBX7) bioplex_WMM hein (CBX7) |
| BMI1 | PHC2 | 0.019 | 0.185 | hein_WMM bioplex_WMM WMM_only |
| BMI1 | PHC3 | 0.017 | 0.173 | hein_WMM bioplex_WMM WMM_only |
| PHC2 | PHC3 | 0.017 | 0.175 | hein_WMM bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_04333 has an average edge precision of 0.516 which is ranked 2413 out of all 6965 complexes.
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