hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04349
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MORF4L1 | Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (Protein MSL3-1) (Transcription factor-like protein MRG15) | UniProt NCBI |
| EP400 | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | UniProt NCBI |
| KAT5 | Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (cPLA(2)-interacting protein) | UniProt NCBI |
| BRD8 | Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) | UniProt NCBI |
| MRGBP | MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4) | UniProt NCBI |
| ING3 | Inhibitor of growth protein 3 (p47ING3) | UniProt NCBI |
| YEATS4 | YEATS domain-containing protein 4 (Glioma-amplified sequence 41) (Gas41) (NuMA-binding protein 1) (NuBI-1) (NuBI1) | UniProt NCBI |
| EPC1 | Enhancer of polycomb homolog 1 | UniProt NCBI |
| EPC2 | Enhancer of polycomb homolog 2 (EPC-like) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:798 | 2.08592902739e-27 | 1.0 | EPC2 MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | NuA4/Tip60-HAT complex A |
| CORUM:2857 | 1.86240087282e-23 | 0.888888888889 | EPC2 KAT5 EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 | NuA4/Tip60 HAT complex |
| CORUM:528 | 3.99062062129e-23 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | NuA4/Tip60-HAT complex |
| GO:0043189 | 4.65853509586e-23 | 1.0 | EPC2 MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | H4/H2A histone acetyltransferase complex |
| GO:0035267 | 4.65853509586e-23 | 1.0 | EPC2 MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | NuA4 histone acetyltransferase complex |
| CORUM:529 | 7.9807644588e-23 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | NuA4/Tip60-HAT complex |
| GO:1902562 | 1.7667494351e-19 | 1.0 | EPC2 MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | H4 histone acetyltransferase complex |
| CORUM:2856 | 4.80933423546e-17 | 0.666666666667 | KAT5 EPC1 EP400 MORF4L1 BRD8 ING3 | NuA4/Tip60 HAT complex |
| GO:0000123 | 9.19647578982e-17 | 1.0 | EPC2 MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | histone acetyltransferase complex |
| GO:1902493 | 2.88126578321e-16 | 1.0 | EPC2 MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | acetyltransferase complex |
| GO:0031248 | 2.88126578321e-16 | 1.0 | EPC2 MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | protein acetyltransferase complex |
| REAC:R-HSA-3214847 | 9.95172122632e-14 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | HATs acetylate histones |
| GO:0043968 | 2.21679144479e-12 | 0.666666666667 | YEATS4 EP400 MORF4L1 EPC1 BRD8 ING3 | histone H2A acetylation |
| GO:0016573 | 2.43239648597e-12 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | histone acetylation |
| GO:0018393 | 2.83472588394e-12 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | internal peptidyl-lysine acetylation |
| GO:0006475 | 4.10517503321e-12 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | internal protein amino acid acetylation |
| GO:0018394 | 4.41183886913e-12 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | peptidyl-lysine acetylation |
| REAC:R-HSA-3247509 | 1.8023103269e-11 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 1.8023103269e-11 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | Chromatin organization |
| GO:0006473 | 3.31658234125e-11 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | protein acetylation |
| GO:0043543 | 1.89767498809e-10 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | protein acylation |
| GO:0032777 | 3.07384073035e-09 | 0.444444444444 | EPC2 EPC1 KAT5 ING3 | Piccolo NuA4 histone acetyltransferase complex |
| GO:0043967 | 6.31458859596e-09 | 0.666666666667 | YEATS4 EP400 MORF4L1 EPC1 BRD8 ING3 | histone H4 acetylation |
| GO:0018205 | 7.42509028435e-09 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | peptidyl-lysine modification |
| GO:0016570 | 2.08448274487e-08 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | histone modification |
| GO:0016569 | 2.9994528829e-08 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | covalent chromatin modification |
| GO:1990234 | 5.25719457291e-08 | 1.0 | EPC2 MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | transferase complex |
| CORUM:787 | 3.52533406442e-07 | 0.333333333333 | EPC1 KAT5 MORF4L1 | NuA4/Tip60-HAT complex B |
| GO:0044451 | 6.24729577516e-07 | 1.0 | EPC2 MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | nucleoplasm part |
| CORUM:799 | 7.54972137794e-07 | 0.333333333333 | EPC1 EP400 BRD8 | DMAP1-associated complex |
| GO:0000812 | 1.51828376741e-06 | 0.444444444444 | BRD8 KAT5 EP400 ING3 | Swr1 complex |
| GO:0006325 | 2.25523237578e-06 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | chromatin organization |
| GO:1902494 | 6.70061170383e-06 | 1.0 | EPC2 MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | catalytic complex |
| GO:0000118 | 7.16131178286e-06 | 0.555555555556 | MORF4L1 BRD8 KAT5 EP400 ING3 | histone deacetylase complex |
| GO:0097346 | 3.8665216288e-05 | 0.444444444444 | BRD8 KAT5 EP400 ING3 | INO80-type complex |
| GO:0018193 | 5.87460343344e-05 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | peptidyl-amino acid modification |
| CORUM:0000000 | 7.29350199909e-05 | 1.0 | EPC2 MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | CORUM root |
| GO:0051276 | 9.38953674575e-05 | 0.888888888889 | MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | chromosome organization |
| GO:0004402 | 0.00111330974298 | 0.444444444444 | EPC2 EPC1 KAT5 ING3 | histone acetyltransferase activity |
| GO:0061733 | 0.00128533198219 | 0.444444444444 | EPC2 EPC1 KAT5 ING3 | peptide-lysine-N-acetyltransferase activity |
| GO:0034212 | 0.00231643936992 | 0.444444444444 | EPC2 EPC1 KAT5 ING3 | peptide N-acetyltransferase activity |
| GO:0070603 | 0.00407883187879 | 0.444444444444 | BRD8 KAT5 EP400 ING3 | SWI/SNF superfamily-type complex |
| GO:0008080 | 0.00407883187879 | 0.444444444444 | EPC2 EPC1 KAT5 ING3 | N-acetyltransferase activity |
| GO:1904949 | 0.00476309999378 | 0.444444444444 | BRD8 KAT5 EP400 ING3 | ATPase complex |
| GO:0016410 | 0.0076745105471 | 0.444444444444 | EPC2 EPC1 KAT5 ING3 | N-acyltransferase activity |
| GO:0016407 | 0.00996136852053 | 0.444444444444 | EPC2 EPC1 KAT5 ING3 | acetyltransferase activity |
| GO:0005654 | 0.0467384203064 | 1.0 | EPC2 MRGBP EPC1 EP400 MORF4L1 YEATS4 BRD8 ING3 KAT5 | nucleoplasm |
| CORUM:724 | 0.0499262710315 | 0.111111111111 | MORF4L1 | MAF2 complex |
| CORUM:7324 | 0.0499262710315 | 0.111111111111 | KAT5 | HINT1-TIP60 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| YEATS4 | EP400 | 1.0 | 0.949 | hein_WMM bioplex (YEATS4) bioplex_WMM Guru youn_WMM hein (YEATS4) fraction |
| KAT5 | ING3 | 1.0 | 0.949 | hein_WMM bioplex (KAT5) bioplex_WMM hein (ING3) |
| YEATS4 | EPC1 | 1.0 | 0.949 | hein_WMM bioplex (YEATS4) bioplex_WMM youn_WMM hein (YEATS4) |
| YEATS4 | KAT5 | 0.999 | 0.948 | hein_WMM bioplex (KAT5,YEATS4) bioplex_WMM hein (YEATS4) |
| MORF4L1 | BRD8 | 0.998 | 0.945 | hein_WMM bioplex (MORF4L1) bioplex_WMM Guru fraction |
| YEATS4 | EPC2 | 0.998 | 0.939 | hein_WMM bioplex (YEATS4) bioplex_WMM hein (YEATS4) |
| YEATS4 | BRD8 | 0.997 | 0.935 | hein_WMM bioplex (YEATS4) bioplex_WMM hein (YEATS4) |
| MORF4L1 | MRGBP | 0.997 | 0.934 | hein_WMM bioplex (MORF4L1,MRGBP) bioplex_WMM Guru fraction |
| YEATS4 | ING3 | 0.993 | 0.918 | hein_WMM bioplex (YEATS4) bioplex_WMM hein (ING3,YEATS4) |
| KAT5 | EPC2 | 0.984 | 0.899 | hein_WMM bioplex (KAT5) bioplex_WMM |
| YEATS4 | MRGBP | 0.976 | 0.891 | hein_WMM bioplex (MRGBP,YEATS4) bioplex_WMM hein (YEATS4) |
| KAT5 | EP400 | 0.969 | 0.881 | hein_WMM bioplex (KAT5) bioplex_WMM youn_WMM |
| MRGBP | BRD8 | 0.968 | 0.88 | hein_WMM bioplex (MRGBP) bioplex_WMM youn_WMM |
| MRGBP | ING3 | 0.965 | 0.874 | hein_WMM bioplex (MRGBP) bioplex_WMM hein (ING3) |
| ING3 | EPC2 | 0.935 | 0.85 | hein_WMM bioplex_WMM hein (ING3) |
| ING3 | EPC1 | 0.92 | 0.844 | hein_WMM bioplex_WMM hein (ING3) |
| MORF4L1 | EP400 | 0.914 | 0.838 | hein_WMM bioplex (MORF4L1) bioplex_WMM |
| KAT5 | EPC1 | 0.901 | 0.825 | hein_WMM bioplex (KAT5) bioplex_WMM youn_WMM |
| ING3 | EP400 | 0.893 | 0.819 | hein_WMM bioplex_WMM hein (ING3) |
| BRD8 | KAT5 | 0.849 | 0.79 | hein_WMM bioplex (KAT5) bioplex_WMM |
| BRD8 | ING3 | 0.845 | 0.788 | hein_WMM bioplex_WMM hein (ING3) |
| MRGBP | EP400 | 0.812 | 0.771 | hein_WMM bioplex (MRGBP) bioplex_WMM youn_WMM |
| MORF4L1 | EPC2 | 0.727 | 0.735 | hein_WMM bioplex (MORF4L1) bioplex_WMM |
| MORF4L1 | YEATS4 | 0.698 | 0.719 | hein_WMM bioplex (MORF4L1,YEATS4) bioplex_WMM hein (YEATS4) |
| MRGBP | KAT5 | 0.665 | 0.7 | hein_WMM bioplex (KAT5,MRGBP) bioplex_WMM |
| MRGBP | EPC2 | 0.544 | 0.643 | hein_WMM bioplex (MRGBP) bioplex_WMM |
| MRGBP | EPC1 | 0.458 | 0.597 | hein_WMM bioplex (MRGBP) bioplex_WMM |
| EPC2 | EP400 | 0.381 | 0.549 | hein_WMM bioplex_WMM Guru youn_WMM fraction |
| MORF4L1 | EPC1 | 0.325 | 0.513 | hein_WMM bioplex (MORF4L1) bioplex_WMM |
| MORF4L1 | ING3 | 0.238 | 0.47 | hein_WMM bioplex (MORF4L1) bioplex_WMM |
| MORF4L1 | KAT5 | 0.191 | 0.443 | hein_WMM bioplex (KAT5,MORF4L1) bioplex_WMM |
| BRD8 | EP400 | 0.152 | 0.409 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| BRD8 | EPC2 | 0.151 | 0.411 | hein_WMM bioplex_WMM WMM_only |
| EPC1 | EP400 | 0.115 | 0.383 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| EPC1 | EPC2 | 0.113 | 0.38 | hein_WMM bioplex_WMM WMM_only |
| BRD8 | EPC1 | 0.112 | 0.381 | hein_WMM bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_04349 has an average edge precision of 0.743 which is ranked 1189 out of all 6965 complexes.
Related Complexes