hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04355
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| C1QBP | Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32) | UniProt NCBI |
| LSM14B | Protein LSM14 homolog B (Protein FAM61B) (RNA-associated protein 55B) (hRAP55B) | UniProt NCBI |
| ICK | Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK) | UniProt NCBI |
| LUC7L | Putative RNA-binding protein Luc7-like 1 (Putative SR protein LUC7B1) (SR+89) | UniProt NCBI |
| SIRT3 | NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 3.5.1.-) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3) | UniProt NCBI |
| UBE2O | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | UniProt NCBI |
| RSPO1 | R-spondin-1 (Roof plate-specific spondin-1) (hRspo1) | UniProt NCBI |
| PRPF38B | Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) | UniProt NCBI |
| LBR | Delta(14)-sterol reductase (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0011838 | 0.000676023207057 | 0.222222222222 | RSPO1 LBR | Sclerodactyly |
| HP:0009487 | 0.0123627209 | 0.222222222222 | ICK LBR | Ulnar deviation of the hand |
| HP:0001552 | 0.0204354580639 | 0.222222222222 | ICK LBR | Barrel-shaped chest |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LUC7L | C1QBP | 0.923 | 0.844 | hein_WMM bioplex (LUC7L) bioplex_WMM hein (C1QBP) fraction |
| PRPF38B | LUC7L | 0.881 | 0.816 | bioplex (LUC7L) bioplex_WMM youn_WMM gupta_WMM |
| LSM14B | LUC7L | 0.302 | 0.497 | hein_WMM bioplex (LUC7L) bioplex_WMM youn_WMM gupta_WMM |
| LBR | C1QBP | 0.288 | 0.489 | hein_WMM bioplex (LBR) bioplex_WMM boldt hein (C1QBP) boldt_WMM |
| LUC7L | UBE2O | 0.153 | 0.411 | bioplex (LUC7L) bioplex_WMM youn_WMM gupta_WMM |
| LSM14B | SIRT3 | 0.115 | 0.385 | bioplex (LSM14B) bioplex_WMM |
| LBR | LUC7L | 0.081 | 0.351 | hein_WMM bioplex (LBR,LUC7L) bioplex_WMM gupta_WMM |
| ICK | LSM14B | 0.032 | 0.242 | bioplex (LSM14B) bioplex_WMM |
| RSPO1 | C1QBP | 0.026 | 0.216 | bioplex (RSPO1) bioplex_WMM |
| LSM14B | PRPF38B | 0.008 | 0.085 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PRPF38B | LBR | 0.007 | 0.004 | bioplex_WMM gupta_WMM WMM_only |
| ICK | C1QBP | 0.007 | 0.0 | boldt boldt_WMM |
| SIRT3 | LBR | 0.007 | 0.001 | bioplex_WMM WMM_only |
| SIRT3 | LUC7L | 0.007 | 0.003 | bioplex_WMM WMM_only |
| ICK | SIRT3 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| SIRT3 | C1QBP | 0.006 | 0.006 | bioplex (SIRT3) |
| LSM14B | UBE2O | 0.006 | 0.001 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ICK | UBE2O | 0.006 | 0.005 | bioplex_WMM WMM_only |
| LBR | UBE2O | 0.005 | 0.01 | bioplex_WMM boldt gupta_WMM boldt_WMM |
| LBR | RSPO1 | 0.005 | 0.008 | bioplex (RSPO1) |
| UBE2O | C1QBP | 0.005 | 0.008 | bioplex (UBE2O) bioplex_WMM boldt boldt_WMM |
| LUC7L | RSPO1 | 0.004 | 0.01 | bioplex (RSPO1) |
| LSM14B | LBR | 0.003 | 0.011 | hein_WMM bioplex (LBR) bioplex_WMM gupta_WMM |
| LSM14B | C1QBP | 0.0 | 0.014 | hein_WMM bioplex (LSM14B) bioplex_WMM hein (C1QBP) |
| PRPF38B | C1QBP | 0.0 | 0.008 | bioplex (PRPF38B) bioplex_WMM fraction |
| PRPF38B | UBE2O | 0.0 | 0.003 | bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_04355 has an average edge precision of 0.17 which is ranked 6520 out of all 6965 complexes.
Related Complexes