hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04365
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TINAGL1 | Tubulointerstitial nephritis antigen-like (Glucocorticoid-inducible protein 5) (Oxidized LDL-responsive gene 2 protein) (OLRG-2) (Tubulointerstitial nephritis antigen-related protein) (TIN Ag-related protein) (TIN-Ag-RP) | UniProt NCBI |
| WDR77 | Methylosome protein 50 (MEP-50) (Androgen receptor cofactor p44) (WD repeat-containing protein 77) (p44/Mep50) | UniProt NCBI |
| PRMT5 | Protein arginine N-methyltransferase 5 (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | UniProt NCBI |
| COPRS | Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1) | UniProt NCBI |
| CLNS1A | Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln) | UniProt NCBI |
| ARFGEF2 | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | UniProt NCBI |
| RIOK1 | Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1) | UniProt NCBI |
| RENBP | N-acylglucosamine 2-epimerase (AGE) (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (RnBP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2838 | 4.70911134935e-09 | 0.375 | PRMT5 CLNS1A WDR77 | MEP50-PRMT5-ICLN complex |
| CORUM:837 | 4.70911134935e-09 | 0.375 | PRMT5 CLNS1A WDR77 | MEP50-PRMT5-ICLN complex |
| CORUM:6853 | 1.16880143691e-05 | 0.25 | COPRS PRMT5 | COPRS-PRMT5 complex |
| CORUM:836 | 1.16880143691e-05 | 0.25 | PRMT5 CLNS1A | 20S methyltransferase core complex |
| CORUM:825 | 3.50546248845e-05 | 0.25 | PRMT5 CLNS1A | JBP1-pICln complex |
| CORUM:6852 | 7.00904180673e-05 | 0.25 | COPRS PRMT5 | COPRS-PRMT5-RUNX1-CBFB complex |
| CORUM:819 | 7.00904180673e-05 | 0.25 | PRMT5 CLNS1A | 20S methylosome-SmD complex |
| CORUM:6858 | 0.00011678598518 | 0.25 | PRMT5 WDR77 | CHTOP-methylosome complex |
| CORUM:832 | 0.000175131922226 | 0.25 | PRMT5 CLNS1A | Anti-Sm protein complex |
| CORUM:834 | 0.000175131922226 | 0.25 | PRMT5 CLNS1A | 20S methylosome and RG-containing Sm protein complex |
| CORUM:810 | 0.000245118829946 | 0.25 | PRMT5 WDR77 | FCP1-associated protein complex |
| CORUM:811 | 0.000245118829946 | 0.25 | PRMT5 WDR77 | FCP1-associated protein complex |
| REAC:R-HSA-194441 | 0.000349320722342 | 0.375 | PRMT5 CLNS1A WDR77 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 0.000349320722342 | 0.375 | PRMT5 CLNS1A WDR77 | snRNP Assembly |
| GO:0034709 | 0.00111635111712 | 0.375 | PRMT5 CLNS1A WDR77 | methylosome |
| REAC:R-HSA-3214858 | 0.00134631412198 | 0.375 | COPRS WDR77 PRMT5 | RMTs methylate histone arginines |
| GO:0034708 | 0.00861930713405 | 0.5 | PRMT5 RIOK1 CLNS1A WDR77 | methyltransferase complex |
| CORUM:2764 | 0.0248670854284 | 0.125 | PRMT5 | PRMT5 complex |
| CORUM:1748 | 0.0248670854284 | 0.125 | PRMT5 | PRMT5 complex |
| GO:0043985 | 0.0378589948753 | 0.25 | COPRS PRMT5 | histone H4-R3 methylation |
| REAC:R-HSA-8953854 | 0.039220545455 | 0.5 | PRMT5 RIOK1 CLNS1A WDR77 | Metabolism of RNA |
| GO:0000387 | 0.0425273681945 | 0.375 | PRMT5 CLNS1A WDR77 | spliceosomal snRNP assembly |
| CORUM:7410 | 0.0497224828424 | 0.125 | PRMT5 | CAPG-PRMT5 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WDR77 | PRMT5 | 1.0 | 0.949 | hein_WMM bioplex (WDR77) bioplex_WMM boldt youn_WMM hein (PRMT5) Malo gupta_WMM fraction boldt_WMM |
| CLNS1A | PRMT5 | 0.865 | 0.801 | hein_WMM bioplex_WMM boldt youn_WMM hein (PRMT5) gupta_WMM boldt_WMM |
| PRMT5 | COPRS | 0.492 | 0.62 | hein_WMM bioplex_WMM youn_WMM hein (PRMT5) gupta_WMM boldt_WMM |
| PRMT5 | RIOK1 | 0.362 | 0.543 | hein_WMM bioplex_WMM boldt youn_WMM hein (PRMT5) gupta_WMM boldt_WMM |
| TINAGL1 | RIOK1 | 0.09 | 0.355 | bioplex (TINAGL1) bioplex_WMM |
| TINAGL1 | PRMT5 | 0.072 | 0.356 | bioplex (TINAGL1) bioplex_WMM |
| WDR77 | RIOK1 | 0.049 | 0.293 | hein_WMM bioplex_WMM boldt youn_WMM boldt_WMM |
| RENBP | TINAGL1 | 0.048 | 0.295 | bioplex (TINAGL1) bioplex_WMM |
| WDR77 | COPRS | 0.033 | 0.253 | hein_WMM bioplex_WMM youn_WMM WMM_only boldt_WMM |
| COPRS | RIOK1 | 0.028 | 0.231 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| CLNS1A | WDR77 | 0.027 | 0.223 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CLNS1A | COPRS | 0.025 | 0.211 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| CLNS1A | RIOK1 | 0.023 | 0.207 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PRMT5 | ARFGEF2 | 0.021 | 0.187 | fraction |
| RENBP | RIOK1 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| RENBP | WDR77 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| RENBP | PRMT5 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| TINAGL1 | WDR77 | 0.007 | 0.005 | bioplex (TINAGL1) bioplex_WMM |
| CLNS1A | TINAGL1 | 0.003 | 0.011 | bioplex (TINAGL1) |
Images
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Complex HuMAP2_04365 has an average edge precision of 0.293 which is ranked 4716 out of all 6965 complexes.
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