hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04366
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRIM2 | DNA primase large subunit (EC 2.7.7.-) (DNA primase 58 kDa subunit) (p58) | UniProt NCBI |
| POLA1 | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | UniProt NCBI |
| POLA2 | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | UniProt NCBI |
| PRIM1 | DNA primase small subunit (EC 2.7.7.-) (DNA primase 49 kDa subunit) (p49) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1100 | 4.53449095762e-14 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA polymerase alpha-primase complex |
| REAC:R-HSA-68952 | 6.34828734067e-12 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA replication initiation |
| REAC:R-HSA-174430 | 6.34828734067e-12 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Telomere C-strand synthesis initiation |
| CORUM:1107 | 9.522431011e-12 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA synthesome core complex |
| CORUM:1098 | 3.2421610347e-11 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA synthesome complex (13 subunits) |
| CORUM:1108 | 6.18958015715e-11 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA synthesome complex (15 subunits) |
| REAC:R-HSA-113501 | 6.4843220694e-11 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-69109 | 9.07805089715e-11 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Leading Strand Synthesis |
| REAC:R-HSA-174411 | 9.07805089715e-11 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Polymerase switching on the C-strand of the telomere |
| REAC:R-HSA-69091 | 9.07805089715e-11 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Polymerase switching |
| REAC:R-HSA-69166 | 9.07805089715e-11 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Removal of the Flap Intermediate |
| CORUM:1111 | 1.07920884791e-10 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 1.07920884791e-10 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA synthesome complex (17 subunits) |
| GO:0005658 | 1.2197780676e-10 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | alpha DNA polymerase:primase complex |
| REAC:R-HSA-69183 | 1.23791603143e-10 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Processive synthesis on the lagging strand |
| REAC:R-HSA-69186 | 4.39392173793e-10 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Lagging Strand Synthesis |
| REAC:R-HSA-113510 | 6.633960271e-10 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | E2F mediated regulation of DNA replication |
| REAC:R-HSA-174417 | 9.63670018313e-10 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Telomere C-strand (Lagging Strand) Synthesis |
| KEGG:03030 | 1.06445966033e-09 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA replication |
| WP:WP466 | 1.69602185225e-09 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA Replication |
| REAC:R-HSA-180786 | 2.48535449387e-09 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Extension of Telomeres |
| REAC:R-HSA-69190 | 3.26120589672e-09 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA strand elongation |
| REAC:R-HSA-68962 | 3.71102739972e-09 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Activation of the pre-replicative complex |
| WP:WP4022 | 2.27666803273e-08 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Pyrimidine metabolism |
| REAC:R-HSA-157579 | 1.50884279717e-07 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Telomere Maintenance |
| REAC:R-HSA-69002 | 1.83627385472e-07 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA Replication Pre-Initiation |
| GO:0043601 | 3.08603851103e-07 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | nuclear replisome |
| GO:0030894 | 4.28142101727e-07 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | replisome |
| GO:0032201 | 4.28142101727e-07 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | telomere maintenance via semi-conservative replication |
| REAC:R-HSA-73886 | 4.8601535637e-07 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Chromosome Maintenance |
| GO:0006270 | 6.68560358851e-07 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA replication initiation |
| REAC:R-HSA-69239 | 6.95938708355e-07 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Synthesis of DNA |
| REAC:R-HSA-69306 | 9.07725736124e-07 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA Replication |
| REAC:R-HSA-69206 | 1.03013477297e-06 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | G1/S Transition |
| GO:0006269 | 1.45302402969e-06 | 0.75 | PRIM2 PRIM1 POLA1 | DNA replication, synthesis of RNA primer |
| REAC:R-HSA-453279 | 1.69335486182e-06 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Mitotic G1-G1/S phases |
| REAC:R-HSA-69242 | 2.3250149843e-06 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | S Phase |
| GO:0043596 | 2.47053849812e-06 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | nuclear replication fork |
| GO:0033260 | 6.60448834702e-06 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | nuclear DNA replication |
| WP:WP45 | 8.93316220103e-06 | 0.75 | POLA2 PRIM1 PRIM2 | G1 to S cell cycle control |
| GO:0044786 | 8.96024572897e-06 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | cell cycle DNA replication |
| GO:0005657 | 1.55003541896e-05 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | replication fork |
| GO:0055029 | 8.10410789889e-05 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 8.45267167948e-05 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA-directed RNA polymerase complex |
| GO:0030880 | 9.56604850625e-05 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | RNA polymerase complex |
| CORUM:1003 | 0.000180886312261 | 0.5 | POLA2 POLA1 | RC complex (Replication competent complex) |
| GO:0006261 | 0.000252118978237 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA-dependent DNA replication |
| REAC:R-HSA-69278 | 0.000264779714116 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Cell Cycle, Mitotic |
| GO:0032993 | 0.000342608092204 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | protein-DNA complex |
| GO:0000723 | 0.000494260781771 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | telomere maintenance |
| REAC:R-HSA-1640170 | 0.000545854331888 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | Cell Cycle |
| GO:0032200 | 0.000691429733885 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | telomere organization |
| GO:0000082 | 0.00161006679656 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | G1/S transition of mitotic cell cycle |
| GO:0006260 | 0.00184822285327 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | DNA replication |
| GO:0044843 | 0.00203384001918 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | cell cycle G1/S phase transition |
| GO:0061695 | 0.00244665292597 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | transferase complex, transferring phosphorus-containing groups |
| WP:WP2446 | 0.00623747495525 | 0.5 | PRIM1 POLA1 | Retinoblastoma Gene in Cancer |
| GO:0060249 | 0.00629241325149 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | anatomical structure homeostasis |
| GO:0003896 | 0.00811409485621 | 0.5 | PRIM2 PRIM1 | DNA primase activity |
| MIRNA:hsa-miR-888-3p | 0.0346755687702 | 0.5 | POLA2 PRIM1 | hsa-miR-888-3p |
| GO:0044772 | 0.0485535587519 | 1.0 | POLA2 POLA1 PRIM1 PRIM2 | mitotic cell cycle phase transition |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRIM1 | POLA1 | 0.968 | 0.88 | hein_WMM bioplex (PRIM1) bioplex_WMM youn_WMM fraction |
| POLA2 | POLA1 | 0.902 | 0.826 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| PRIM1 | PRIM2 | 0.82 | 0.773 | hein_WMM bioplex (PRIM1) bioplex_WMM youn_WMM |
| PRIM1 | POLA2 | 0.644 | 0.687 | hein_WMM bioplex (PRIM1) bioplex_WMM youn_WMM fraction |
| PRIM2 | POLA1 | 0.01 | 0.107 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PRIM2 | POLA2 | 0.009 | 0.107 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_04366 has an average edge precision of 0.563 which is ranked 2115 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRIM2 | HuMAP2_00528 HuMAP2_01177 HuMAP2_04366 HuMAP2_06629 |
| POLA1 | HuMAP2_00663 HuMAP2_01177 HuMAP2_01225 HuMAP2_03670 HuMAP2_04366 HuMAP2_06629 |
| POLA2 | HuMAP2_00663 HuMAP2_01177 HuMAP2_01225 HuMAP2_01835 HuMAP2_04366 HuMAP2_06629 |
| PRIM1 | HuMAP2_00528 HuMAP2_01177 HuMAP2_04366 HuMAP2_06629 |