hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04367
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSP90AA1 | Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | UniProt NCBI |
| HSP90AB1 | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2112 | 1.00555407742e-05 | 1.0 | HSP90AA1 HSP90AB1 | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex |
| CORUM:5234 | 1.67592346237e-05 | 1.0 | HSP90AA1 HSP90AB1 | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex |
| REAC:R-HSA-5336415 | 1.67592346237e-05 | 1.0 | HSP90AA1 HSP90AB1 | Uptake and function of diphtheria toxin |
| CORUM:5269 | 2.51388519356e-05 | 1.0 | HSP90AA1 HSP90AB1 | TNF-alpha/NF-kappa B signaling complex 8 |
| CORUM:5212 | 4.69258569465e-05 | 1.0 | HSP90AA1 HSP90AB1 | Kinase maturation complex 2 |
| CORUM:5268 | 4.69258569465e-05 | 1.0 | HSP90AA1 HSP90AB1 | TNF-alpha/NF-kappa B signaling complex 7 |
| CORUM:5286 | 7.54165558069e-05 | 1.0 | HSP90AA1 HSP90AB1 | TNF-alpha/NF-kappa B signaling complex 10 |
| REAC:R-HSA-3371511 | 0.000110610948517 | 1.0 | HSP90AA1 HSP90AB1 | HSF1 activation |
| REAC:R-HSA-3371568 | 0.000130722030065 | 1.0 | HSP90AA1 HSP90AB1 | Attenuation phase |
| CORUM:5266 | 0.000152509035076 | 1.0 | HSP90AA1 HSP90AB1 | TNF-alpha/NF-kappa B signaling complex 6 |
| REAC:R-HSA-9613829 | 0.000175971963549 | 1.0 | HSP90AA1 HSP90AB1 | Chaperone Mediated Autophagy |
| CORUM:5199 | 0.000201110815485 | 1.0 | HSP90AA1 HSP90AB1 | Kinase maturation complex 1 |
| REAC:R-HSA-399954 | 0.000201110815485 | 1.0 | HSP90AA1 HSP90AB1 | Sema3A PAK dependent Axon repulsion |
| KEGG:04612 | 0.000208779385658 | 1.0 | HSP90AA1 HSP90AB1 | Antigen processing and presentation |
| REAC:R-HSA-5339562 | 0.000351943927099 | 1.0 | HSP90AA1 HSP90AB1 | Uptake and actions of bacterial toxins |
| KEGG:04657 | 0.000352342569087 | 1.0 | HSP90AA1 HSP90AB1 | IL-17 signaling pathway |
| REAC:R-HSA-3371571 | 0.000424008635981 | 1.0 | HSP90AA1 HSP90AB1 | HSF1-dependent transactivation |
| KEGG:04914 | 0.000472708042999 | 1.0 | HSP90AA1 HSP90AB1 | Progesterone-mediated oocyte maturation |
| KEGG:04659 | 0.000533255523815 | 1.0 | HSP90AA1 HSP90AB1 | Th17 cell differentiation |
| KEGG:05215 | 0.000584319664263 | 1.0 | HSP90AA1 HSP90AB1 | Prostate cancer |
| KEGG:04915 | 0.00107686977326 | 1.0 | HSP90AA1 HSP90AB1 | Estrogen signaling pathway |
| KEGG:05418 | 0.00113070596705 | 1.0 | HSP90AA1 HSP90AB1 | Fluid shear stress and atherosclerosis |
| KEGG:04217 | 0.0016743202165 | 1.0 | HSP90AA1 HSP90AB1 | Necroptosis |
| KEGG:04141 | 0.00178666132548 | 1.0 | HSP90AA1 HSP90AB1 | Protein processing in endoplasmic reticulum |
| KEGG:04621 | 0.00180956723991 | 1.0 | HSP90AA1 HSP90AB1 | NOD-like receptor signaling pathway |
| REAC:R-HSA-3371497 | 0.00222227451111 | 1.0 | HSP90AA1 HSP90AB1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| WP:WP2884 | 0.00227460903014 | 1.0 | HSP90AA1 HSP90AB1 | NRF2 pathway |
| REAC:R-HSA-2029482 | 0.00286750504412 | 1.0 | HSP90AA1 HSP90AB1 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-373755 | 0.00286750504412 | 1.0 | HSP90AA1 HSP90AB1 | Semaphorin interactions |
| GO:0030911 | 0.00450823411379 | 1.0 | HSP90AA1 HSP90AB1 | TPR domain binding |
| REAC:R-HSA-8852276 | 0.00477638186777 | 1.0 | HSP90AA1 HSP90AB1 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| REAC:R-HSA-2029480 | 0.0052959181411 | 1.0 | HSP90AA1 HSP90AB1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-3371556 | 0.00598304676068 | 1.0 | HSP90AA1 HSP90AB1 | Cellular response to heat stress |
| KEGG:04151 | 0.00654350485448 | 1.0 | HSP90AA1 HSP90AB1 | PI3K-Akt signaling pathway |
| GO:1905323 | 0.00676235117068 | 1.0 | HSP90AA1 HSP90AB1 | telomerase holoenzyme complex assembly |
| GO:1902949 | 0.00676235117068 | 1.0 | HSP90AA1 HSP90AB1 | positive regulation of tau-protein kinase activity |
| GO:0030235 | 0.00676235117068 | 1.0 | HSP90AA1 HSP90AB1 | nitric-oxide synthase regulator activity |
| GO:0044294 | 0.00676235117068 | 1.0 | HSP90AA1 HSP90AB1 | dendritic growth cone |
| REAC:R-HSA-9612973 | 0.00880362594785 | 1.0 | HSP90AA1 HSP90AB1 | Autophagy |
| GO:0044292 | 0.00946729163895 | 1.0 | HSP90AA1 HSP90AB1 | dendrite terminus |
| WP:WP3932 | 0.0121610546673 | 1.0 | HSP90AA1 HSP90AB1 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| WP:WP2882 | 0.0123521888904 | 1.0 | HSP90AA1 HSP90AB1 | Nuclear Receptors Meta-Pathway |
| WP:WP4172 | 0.015291110435 | 1.0 | HSP90AA1 HSP90AB1 | PI3K-Akt Signaling Pathway |
| KEGG:05200 | 0.0157394270613 | 1.0 | HSP90AA1 HSP90AB1 | Pathways in cancer |
| GO:1902947 | 0.0162296428096 | 1.0 | HSP90AA1 HSP90AB1 | regulation of tau-protein kinase activity |
| REAC:R-HSA-9018519 | 0.0165413645736 | 1.0 | HSP90AA1 HSP90AB1 | Estrogen-dependent gene expression |
| CORUM:6402 | 0.0249595281251 | 0.5 | HSP90AA1 | NMNAT2-HSP90 complex |
| MIRNA:hsa-miR-501-5p | 0.0268049823513 | 1.0 | HSP90AA1 HSP90AB1 | hsa-miR-501-5p |
| REAC:R-HSA-69275 | 0.0300912057669 | 1.0 | HSP90AA1 HSP90AB1 | G2/M Transition |
| REAC:R-HSA-453274 | 0.0307297326061 | 1.0 | HSP90AA1 HSP90AB1 | Mitotic G2-G2/M phases |
| REAC:R-HSA-8939211 | 0.0347016712119 | 1.0 | HSP90AA1 HSP90AB1 | ESR-mediated signaling |
| GO:0023026 | 0.0410249304355 | 1.0 | HSP90AA1 HSP90AB1 | MHC class II protein complex binding |
| GO:0044295 | 0.0473364581948 | 1.0 | HSP90AA1 HSP90AB1 | axonal growth cone |
| GO:0023023 | 0.0473364581948 | 1.0 | HSP90AA1 HSP90AB1 | MHC protein complex binding |
| REAC:R-HSA-9006931 | 0.0496844269656 | 1.0 | HSP90AA1 HSP90AB1 | Signaling by Nuclear Receptors |
| REAC:R-HSA-192905 | 0.0499173803268 | 0.5 | HSP90AA1 | vRNP Assembly |
| CORUM:5716 | 0.0499173803268 | 0.5 | HSP90AA1 | NOS3-HSP90 complex, VEGF induced |
| CORUM:6591 | 0.0499173803268 | 0.5 | HSP90AA1 | Hsp90-p23 complex |
| CORUM:6706 | 0.0499173803268 | 0.5 | HSP90AB1 | CAPN1-HSP90AB1 complex |
| CORUM:4158 | 0.0499173803268 | 0.5 | HSP90AA1 | HSP90-FKBP38-CAM-Ca(2+) complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HSP90AA1 | HSP90AB1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt hein (HSP90AA1) Malo fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_04367 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HSP90AA1 | HuMAP2_04367 HuMAP2_05213 HuMAP2_06797 |
| HSP90AB1 | HuMAP2_04367 HuMAP2_04784 HuMAP2_05213 HuMAP2_06797 |