hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04369
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CSNK1D | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | UniProt NCBI |
| CSNK1E | Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04710 | 5.9234402919e-05 | 1.0 | CSNK1E CSNK1D | Circadian rhythm |
| KEGG:04340 | 0.000138019076752 | 1.0 | CSNK1E CSNK1D | Hedgehog signaling pathway |
| WP:WP3298 | 0.000173250319249 | 1.0 | CSNK1E CSNK1D | Melatonin metabolism and effects |
| WP:WP4249 | 0.000261924676198 | 1.0 | CSNK1E CSNK1D | Hedgehog Signaling Pathway |
| WP:WP363 | 0.0004381556461 | 1.0 | CSNK1E CSNK1D | Wnt Signaling Pathway |
| GO:1904956 | 0.000450823411379 | 1.0 | CSNK1E CSNK1D | regulation of midbrain dopaminergic neuron differentiation |
| GO:1904958 | 0.000450823411379 | 1.0 | CSNK1E CSNK1D | positive regulation of midbrain dopaminergic neuron differentiation |
| GO:1905424 | 0.000450823411379 | 1.0 | CSNK1E CSNK1D | regulation of Wnt-mediated midbrain dopaminergic neuron differentiation |
| GO:1905426 | 0.000450823411379 | 1.0 | CSNK1E CSNK1D | positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation |
| GO:1904340 | 0.00135247023414 | 1.0 | CSNK1E CSNK1D | positive regulation of dopaminergic neuron differentiation |
| KEGG:04390 | 0.00146058031434 | 1.0 | CSNK1E CSNK1D | Hippo signaling pathway |
| MIRNA:hsa-miR-6772-3p | 0.00268864564617 | 1.0 | CSNK1E CSNK1D | hsa-miR-6772-3p |
| REAC:R-HSA-400253 | 0.00348592080174 | 1.0 | CSNK1E CSNK1D | Circadian Clock |
| REAC:R-HSA-380259 | 0.00370546677531 | 1.0 | CSNK1E CSNK1D | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 0.00370546677531 | 1.0 | CSNK1E CSNK1D | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-8854518 | 0.00404735516163 | 1.0 | CSNK1E CSNK1D | AURKA Activation by TPX2 |
| WP:WP3594 | 0.00485883314693 | 1.0 | CSNK1E CSNK1D | Circadian rhythm related genes |
| REAC:R-HSA-380270 | 0.00516352018758 | 1.0 | CSNK1E CSNK1D | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-380287 | 0.00516352018758 | 1.0 | CSNK1E CSNK1D | Centrosome maturation |
| REAC:R-HSA-2565942 | 0.00584226918984 | 1.0 | CSNK1E CSNK1D | Regulation of PLK1 Activity at G2/M Transition |
| MIRNA:hsa-miR-4448 | 0.00618660078988 | 1.0 | CSNK1E CSNK1D | hsa-miR-4448 |
| MIRNA:hsa-miR-4268 | 0.00637127544033 | 1.0 | CSNK1E CSNK1D | hsa-miR-4268 |
| REAC:R-HSA-380320 | 0.00671207346681 | 1.0 | CSNK1E CSNK1D | Recruitment of NuMA to mitotic centrosomes |
| GO:1904338 | 0.00676235117068 | 1.0 | CSNK1E CSNK1D | regulation of dopaminergic neuron differentiation |
| REAC:R-HSA-5620912 | 0.0074829982595 | 1.0 | CSNK1E CSNK1D | Anchoring of the basal body to the plasma membrane |
| GO:2000052 | 0.0126230555186 | 1.0 | CSNK1E CSNK1D | positive regulation of non-canonical Wnt signaling pathway |
| MIRNA:hsa-miR-5192 | 0.0174924915222 | 1.0 | CSNK1E CSNK1D | hsa-miR-5192 |
| REAC:R-HSA-6791226 | 0.0273007932021 | 1.0 | CSNK1E CSNK1D | Major pathway of rRNA processing in the nucleolus and cytosol |
| GO:1904953 | 0.029754345151 | 1.0 | CSNK1E CSNK1D | Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
| REAC:R-HSA-69275 | 0.0300912057669 | 1.0 | CSNK1E CSNK1D | G2/M Transition |
| REAC:R-HSA-5617833 | 0.0304096312248 | 1.0 | CSNK1E CSNK1D | Cilium Assembly |
| REAC:R-HSA-8868773 | 0.0304096312248 | 1.0 | CSNK1E CSNK1D | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-68877 | 0.0304096312248 | 1.0 | CSNK1E CSNK1D | Mitotic Prometaphase |
| REAC:R-HSA-453274 | 0.0307297326061 | 1.0 | CSNK1E CSNK1D | Mitotic G2-G2/M phases |
| REAC:R-HSA-72312 | 0.0336860615937 | 1.0 | CSNK1E CSNK1D | rRNA processing |
| GO:1904948 | 0.0351642260875 | 1.0 | CSNK1E CSNK1D | midbrain dopaminergic neuron differentiation |
| HPA:024010_23 | 0.0353577952474 | 1.0 | CSNK1E CSNK1D | kidney; cells in glomeruli[Approved,High] |
| GO:2000050 | 0.0473364581948 | 1.0 | CSNK1E CSNK1D | regulation of non-canonical Wnt signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CSNK1E | CSNK1D | 0.975 | 0.887 | hein_WMM bioplex (CSNK1E) bioplex_WMM hein (CSNK1D) |
Images
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Complex HuMAP2_04369 has an average edge precision of 0.887 which is ranked 627 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CSNK1D | HuMAP2_00180 HuMAP2_01354 HuMAP2_01754 HuMAP2_03029 HuMAP2_03490 HuMAP2_04369 |
| CSNK1E | HuMAP2_00180 HuMAP2_01354 HuMAP2_01754 HuMAP2_03029 HuMAP2_03490 HuMAP2_04369 |