hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04371

Confidence: Medium

Genename	Protein Name	Links
BAK1	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)	UniProt NCBI
MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)	UniProt NCBI
PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)	UniProt NCBI
BBC3	Bcl-2-binding component 3 (JFY-1) (p53 up-regulated modulator of apoptosis)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP254	1.64924601505e-08	1.0	BAK1 MCL1 BBC3 PMAIP1	Apoptosis
WP:WP1772	2.52098579154e-08	1.0	BAK1 MCL1 BBC3 PMAIP1	Apoptosis Modulation and Signaling
KEGG:04210	1.7513076548e-07	1.0	BAK1 MCL1 BBC3 PMAIP1	Apoptosis
KEGG:04215	1.09102814336e-06	0.75	BAK1 PMAIP1 BBC3	Apoptosis - multiple species
WP:WP3614	1.2292110584e-06	0.75	BAK1 MCL1 PMAIP1	Photodynamic therapy-induced HIF-1 survival signaling
CORUM:5823	5.02777038712e-06	0.5	BAK1 MCL1	MCL1-BAK1 complex
WP:WP4216	1.28520696315e-05	0.75	BAK1 PMAIP1 BBC3	Chromosomal and microsatellite instability in colorectal cancer
KEGG:01524	1.59928783462e-05	0.75	BAK1 PMAIP1 BBC3	Platinum drug resistance
KEGG:05210	2.37359736806e-05	0.75	BAK1 PMAIP1 BBC3	Colorectal cancer
REAC:R-HSA-109606	2.64063995051e-05	0.75	BAK1 PMAIP1 BBC3	Intrinsic Pathway for Apoptosis
WP:WP710	4.08802374395e-05	0.75	BAK1 PMAIP1 BBC3	DNA Damage Response (only ATM dependent)
GO:2001235	0.000130738130864	1.0	BAK1 MCL1 BBC3 PMAIP1	positive regulation of apoptotic signaling pathway
MIRNA:hsa-miR-125b-5p	0.000169888048006	1.0	BAK1 MCL1 BBC3 PMAIP1	hsa-miR-125b-5p
GO:0005741	0.000214275729623	1.0	BAK1 MCL1 BBC3 PMAIP1	mitochondrial outer membrane
WP:WP1742	0.000228185108581	0.5	PMAIP1 BBC3	TP53 Network
GO:0031968	0.00029476632277	1.0	BAK1 MCL1 BBC3 PMAIP1	organelle outer membrane
GO:0019867	0.000303906363787	1.0	BAK1 MCL1 BBC3 PMAIP1	outer membrane
WP:WP3872	0.000318702346676	0.5	BAK1 MCL1	Regulation of Apoptosis by Parathyroid Hormone-related Protein
REAC:R-HSA-111453	0.000361772624521	0.5	PMAIP1 BBC3	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
WP:WP3982	0.000387405527127	0.5	PMAIP1 BBC3	miRNA regulation of p53 pathway in prostate cancer
REAC:R-HSA-109581	0.00105827201724	0.75	BAK1 PMAIP1 BBC3	Apoptosis
REAC:R-HSA-5357801	0.00111581489513	0.75	BAK1 PMAIP1 BBC3	Programmed Cell Death
GO:0097193	0.00157802566628	1.0	BAK1 MCL1 BBC3 PMAIP1	intrinsic apoptotic signaling pathway
WP:WP3611	0.00180886504004	0.5	BAK1 MCL1	Photodynamic therapy-induced AP-1 survival signaling.
REAC:R-HSA-6803204	0.0019074750117	0.5	PMAIP1 BBC3	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
GO:1901030	0.00197902980402	0.75	BAK1 PMAIP1 BBC3	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1905898	0.00197902980402	0.75	BAK1 PMAIP1 BBC3	positive regulation of response to endoplasmic reticulum stress
GO:1901028	0.00331394418715	0.75	BAK1 PMAIP1 BBC3	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2001244	0.00331394418715	0.75	MCL1 BBC3 PMAIP1	positive regulation of intrinsic apoptotic signaling pathway
WP:WP707	0.00369308954062	0.5	PMAIP1 BBC3	DNA Damage Response
GO:2001233	0.00381401733339	1.0	BAK1 MCL1 BBC3 PMAIP1	regulation of apoptotic signaling pathway
KEGG:04115	0.00401698930658	0.5	PMAIP1 BBC3	p53 signaling pathway
WP:WP1530	0.00403274972955	0.5	PMAIP1 BBC3	miRNA Regulation of DNA Damage Response
REAC:R-HSA-114452	0.00436320194063	0.5	PMAIP1 BBC3	Activation of BH3-only proteins
KEGG:05200	0.00437599198048	0.75	BAK1 PMAIP1 BBC3	Pathways in cancer
GO:0001836	0.00447413621813	0.75	BAK1 PMAIP1 BBC3	release of cytochrome c from mitochondria
GO:0070059	0.00447413621813	0.75	BAK1 PMAIP1 BBC3	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0097345	0.0062689516986	0.75	BAK1 PMAIP1 BBC3	mitochondrial outer membrane permeabilization
GO:1902110	0.00710332146687	0.75	BAK1 PMAIP1 BBC3	positive regulation of mitochondrial membrane permeability involved in apoptotic process
REAC:R-HSA-5633008	0.0078166615373	0.5	PMAIP1 BBC3	TP53 Regulates Transcription of Cell Death Genes
GO:1902686	0.0080085486554	0.75	BAK1 PMAIP1 BBC3	mitochondrial outer membrane permeabilization involved in programmed cell death
GO:0035794	0.00848863295691	0.75	BAK1 PMAIP1 BBC3	positive regulation of mitochondrial membrane permeability
GO:1902108	0.00848863295691	0.75	BAK1 PMAIP1 BBC3	regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1905710	0.00898751047669	0.75	BAK1 PMAIP1 BBC3	positive regulation of membrane permeability
GO:0046902	0.0111781410126	0.75	BAK1 PMAIP1 BBC3	regulation of mitochondrial membrane permeability
WP:WP4396	0.0154631487697	0.5	BAK1 BBC3	Nonalcoholic fatty liver disease
GO:0090559	0.0158182712902	0.75	BAK1 PMAIP1 BBC3	regulation of membrane permeability
KEGG:05162	0.0161026004622	0.5	BAK1 BBC3	Measles
GO:1905897	0.0198185309013	0.75	BAK1 PMAIP1 BBC3	regulation of response to endoplasmic reticulum stress
GO:0097190	0.0206423804985	1.0	BAK1 MCL1 BBC3 PMAIP1	apoptotic signaling pathway
KEGG:05206	0.0241976216174	0.5	BAK1 MCL1	MicroRNAs in cancer
GO:0043065	0.0272124122863	1.0	BAK1 MCL1 BBC3 PMAIP1	positive regulation of apoptotic process
GO:0043068	0.0288632862702	1.0	BAK1 MCL1 BBC3 PMAIP1	positive regulation of programmed cell death
WP:WP4399	0.0333519728792	0.25	MCL1	MicroRNA network associated with chronic lymphocytic leukemia
MIRNA:hsa-miR-876-3p	0.0335416748159	0.5	MCL1 BBC3	hsa-miR-876-3p
KEGG:05203	0.03463652866	0.5	BAK1 PMAIP1	Viral carcinogenesis
GO:0010942	0.0403998712414	1.0	BAK1 MCL1 BBC3 PMAIP1	positive regulation of cell death
GO:0097136	0.0405595771497	0.5	BAK1 MCL1	Bcl-2 family protein complex
GO:1902237	0.0405595771497	0.5	PMAIP1 BBC3	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
MIRNA:hsa-miR-892b	0.0418723532423	0.5	MCL1 PMAIP1	hsa-miR-892b
GO:0008637	0.0439367749778	0.75	BAK1 PMAIP1 BBC3	apoptotic mitochondrial changes

Edges

Protein 1	Protein 2	Score	Precision	Evidence
BAK1	MCL1	0.998	0.939	bioplex (MCL1)
MCL1	BBC3	0.628	0.68	bioplex (MCL1)
MCL1	PMAIP1	0.242	0.468	bioplex (MCL1)
BAK1	BBC3	0.009	0.104	bioplex_WMM WMM_only
BAK1	PMAIP1	0.009	0.095	bioplex_WMM WMM_only
BBC3	PMAIP1	0.008	0.091	bioplex_WMM WMM_only

Images

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Complex HuMAP2_04371 has an average edge precision of 0.396 which is ranked 3367 out of all 6965 complexes.

Related Complexes

Genename	Complexes
BAK1	HuMAP2_00283 HuMAP2_00612 HuMAP2_03955 HuMAP2_04371 HuMAP2_05310
MCL1	HuMAP2_00283 HuMAP2_00612 HuMAP2_03955 HuMAP2_04371 HuMAP2_05310 HuMAP2_05402 HuMAP2_06133
PMAIP1	HuMAP2_00283 HuMAP2_00612 HuMAP2_04371
BBC3	HuMAP2_00283 HuMAP2_00612 HuMAP2_03955 HuMAP2_04371 HuMAP2_06133 HuMAP2_06564

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04371