hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04373
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RCAN1 | Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1) | UniProt NCBI |
| PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) | UniProt NCBI |
| ARHGDIB | Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta) | UniProt NCBI |
| PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform) | UniProt NCBI |
| RCAN2 | Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4) | UniProt NCBI |
| PPP3CA | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit alpha isoform) | UniProt NCBI |
| PPP3R1 | Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) | UniProt NCBI |
| ARMT1 | Damage-control phosphatase ARMT1 (EC 3.1.3.-) (Acidic residue methyltransferase 1) (Protein-glutamate O-methyltransferase) (EC 2.1.1.-) (Sugar phosphate phosphatase ARMT1) | UniProt NCBI |
| RCAN3 | Calcipressin-3 (Down syndrome candidate region 1-like protein 2) (Myocyte-enriched calcineurin-interacting protein 3) (MCIP3) (Regulator of calcineurin 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0097720 | 2.99645506801e-13 | 0.777777777778 | PPP3R1 RCAN2 PPP3CA PPP3CC RCAN1 PPP3CB RCAN3 | calcineurin-mediated signaling |
| GO:0033173 | 2.99645506801e-13 | 0.777777777778 | PPP3R1 RCAN2 PPP3CA PPP3CC RCAN1 PPP3CB RCAN3 | calcineurin-NFAT signaling cascade |
| GO:0048016 | 7.026193394e-13 | 0.777777777778 | PPP3R1 RCAN2 PPP3CA PPP3CC RCAN1 PPP3CB RCAN3 | inositol phosphate-mediated signaling |
| GO:0005955 | 3.07384073035e-09 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | calcineurin complex |
| CORUM:2266 | 6.30476064954e-09 | 0.333333333333 | PPP3CB RCAN1 PPP3CA | PPP3CA-PPP3CA-RCAN1 complex |
| GO:0019722 | 7.22507601688e-09 | 0.777777777778 | PPP3R1 RCAN2 PPP3CA PPP3CC RCAN1 PPP3CB RCAN3 | calcium-mediated signaling |
| WP:WP3414 | 1.00181892753e-07 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Initiation of transcription and translation elongation at the HIV-1 LTR |
| GO:0004723 | 1.07497741607e-07 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | calcium-dependent protein serine/threonine phosphatase activity |
| REAC:R-HSA-180024 | 1.07889289355e-07 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | DARPP-32 events |
| KEGG:04921 | 3.55740384866e-07 | 0.555555555556 | PPP3CC PPP3CA PPP3R1 RCAN1 PPP3CB | Oxytocin signaling pathway |
| WP:WP1541 | 5.42473197842e-07 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Energy Metabolism |
| GO:0019932 | 6.21330293907e-07 | 0.777777777778 | PPP3R1 RCAN2 PPP3CA PPP3CC RCAN1 PPP3CB RCAN3 | second-messenger-mediated signaling |
| KEGG:05014 | 7.76360257167e-07 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Amyotrophic lateral sclerosis (ALS) |
| KEGG:04924 | 9.09224914802e-07 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Renin secretion |
| KEGG:05167 | 9.77046206902e-07 | 0.555555555556 | PPP3CC PPP3CA PPP3R1 RCAN1 PPP3CB | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04370 | 1.05840945927e-06 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | VEGF signaling pathway |
| REAC:R-HSA-2025928 | 1.062486017e-06 | 0.333333333333 | PPP3CB PPP3R1 PPP3CA | Calcineurin activates NFAT |
| KEGG:04720 | 1.7279217727e-06 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Long-term potentiation |
| KEGG:05031 | 1.7279217727e-06 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Amphetamine addiction |
| KEGG:04662 | 2.37097171947e-06 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | B cell receptor signaling pathway |
| REAC:R-HSA-5607763 | 2.54842526183e-06 | 0.333333333333 | PPP3CB PPP3R1 PPP3CA | CLEC7A (Dectin-1) induces NFAT activation |
| KEGG:04658 | 3.00234512936e-06 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Th1 and Th2 cell differentiation |
| KEGG:05235 | 4.87523029047e-06 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| WP:WP2059 | 5.7043113698e-06 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Alzheimers Disease |
| KEGG:04659 | 6.53529083824e-06 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Th17 cell differentiation |
| KEGG:04625 | 7.17257727184e-06 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | C-type lectin receptor signaling pathway |
| GO:0008597 | 7.62876038594e-06 | 0.333333333333 | RCAN3 RCAN1 RCAN2 | calcium-dependent protein serine/threonine phosphatase regulator activity |
| KEGG:04660 | 7.85517967974e-06 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | T cell receptor signaling pathway |
| KEGG:04922 | 1.01958736136e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Glucagon signaling pathway |
| KEGG:04650 | 1.15444043478e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Natural killer cell mediated cytotoxicity |
| KEGG:04724 | 1.20221769498e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Glutamatergic synapse |
| CORUM:6023 | 1.34129279418e-05 | 0.222222222222 | PPP3CA PPP3R1 | Calcineurin |
| KEGG:04380 | 1.35443231758e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Osteoclast differentiation |
| KEGG:04114 | 1.57921761709e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Oocyte meiosis |
| WP:WP428 | 1.84777917592e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Wnt Signaling |
| REAC:R-HSA-111885 | 2.54381639401e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Opioid Signalling |
| CORUM:6374 | 4.02261743042e-05 | 0.222222222222 | PPP3CA PPP3R1 | Calcineurin-FKBP12 complex |
| KEGG:04022 | 4.78390127337e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | cGMP-PKG signaling pathway |
| REAC:R-HSA-2871809 | 5.35023353638e-05 | 0.333333333333 | PPP3CB PPP3R1 PPP3CA | FCERI mediated Ca+2 mobilization |
| KEGG:04218 | 5.35089478374e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Cellular senescence |
| KEGG:04310 | 5.65245832958e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Wnt signaling pathway |
| KEGG:05152 | 6.1283131133e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Tuberculosis |
| KEGG:05010 | 6.80843393997e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Alzheimer disease |
| GO:0033192 | 7.62415024416e-05 | 0.333333333333 | PPP3CC PPP3CA PPP3CB | calmodulin-dependent protein phosphatase activity |
| WP:WP2447 | 7.62618405823e-05 | 0.333333333333 | PPP3CC PPP3CA PPP3CB | Amyotrophic lateral sclerosis (ALS) |
| KEGG:04020 | 7.73580653256e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Calcium signaling pathway |
| KEGG:04360 | 8.96917486091e-05 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Axon guidance |
| KEGG:05166 | 0.000181767905241 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Human T-cell leukemia virus 1 infection |
| KEGG:05170 | 0.000189218557965 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.000200817023016 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | Human cytomegalovirus infection |
| GO:1903293 | 0.000250458357857 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | phosphatase complex |
| GO:0008287 | 0.000250458357857 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | protein serine/threonine phosphatase complex |
| WP:WP382 | 0.000323884519488 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | MAPK Signaling Pathway |
| KEGG:04010 | 0.000513735736637 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | MAPK signaling pathway |
| WP:WP1544 | 0.000628245131475 | 0.333333333333 | PPP3CB RCAN1 PPP3CA | MicroRNAs in cardiomyocyte hypertrophy |
| REAC:R-HSA-4086398 | 0.000701309789929 | 0.333333333333 | PPP3CB PPP3R1 PPP3CA | Ca2+ pathway |
| REAC:R-HSA-418594 | 0.00215858652987 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | G alpha (i) signalling events |
| KEGG:04728 | 0.00216971375766 | 0.333333333333 | PPP3CC PPP3CA PPP3CB | Dopaminergic synapse |
| REAC:R-HSA-1168372 | 0.00217404889806 | 0.333333333333 | PPP3CB PPP3R1 PPP3CA | Downstream signaling events of B Cell Receptor (BCR) |
| GO:0004722 | 0.00217873139676 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | protein serine/threonine phosphatase activity |
| REAC:R-HSA-5607764 | 0.00371536237315 | 0.333333333333 | PPP3CB PPP3R1 PPP3CA | CLEC7A (Dectin-1) signaling |
| GO:0016791 | 0.00394370499988 | 0.555555555556 | ARMT1 PPP3R1 PPP3CB PPP3CA PPP3CC | phosphatase activity |
| WP:WP4482 | 0.00405747017277 | 0.222222222222 | PPP3CA PPP3R1 | Vitamin D in inflammatory diseases |
| WP:WP1528 | 0.00488522165191 | 0.222222222222 | PPP3CB PPP3CA | Physiological and Pathological Hypertrophy of the Heart |
| REAC:R-HSA-983705 | 0.00491700869461 | 0.333333333333 | PPP3CB PPP3R1 PPP3CA | Signaling by the B Cell Receptor (BCR) |
| GO:0005516 | 0.00580463861904 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | calmodulin binding |
| REAC:R-HSA-111447 | 0.00676168485278 | 0.222222222222 | PPP3CC PPP3R1 | Activation of BAD and translocation to mitochondria |
| REAC:R-HSA-2454202 | 0.00823856739508 | 0.333333333333 | PPP3CB PPP3R1 PPP3CA | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-5621481 | 0.0095313189047 | 0.333333333333 | PPP3CB PPP3R1 PPP3CA | C-type lectin receptors (CLRs) |
| REAC:R-HSA-3858494 | 0.0122347169134 | 0.333333333333 | PPP3CB PPP3R1 PPP3CA | Beta-catenin independent WNT signaling |
| WP:WP3888 | 0.0147748088741 | 0.333333333333 | PPP3CA RCAN1 RCAN2 | VEGFA-VEGFR2 Signaling Pathway |
| GO:0042578 | 0.0162563627475 | 0.555555555556 | ARMT1 PPP3R1 PPP3CB PPP3CA PPP3CC | phosphoric ester hydrolase activity |
| GO:0048583 | 0.0165443681938 | 1.0 | PPP3R1 RCAN2 PPP3CC ARMT1 ARHGDIB PPP3CA RCAN1 RCAN3 PPP3CB | regulation of response to stimulus |
| GO:0070884 | 0.0174298251805 | 0.333333333333 | RCAN3 RCAN1 RCAN2 | regulation of calcineurin-NFAT signaling cascade |
| GO:0106056 | 0.0174298251805 | 0.333333333333 | RCAN3 RCAN1 RCAN2 | regulation of calcineurin-mediated signaling |
| REAC:R-HSA-114452 | 0.0278812797455 | 0.222222222222 | PPP3CC PPP3R1 | Activation of BH3-only proteins |
| REAC:R-HSA-388396 | 0.036560466341 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | GPCR downstream signalling |
| GO:0035556 | 0.0384085684948 | 0.888888888889 | PPP3R1 RCAN2 PPP3CA ARHGDIB PPP3CC RCAN1 RCAN3 PPP3CB | intracellular signal transduction |
| GO:0007223 | 0.0412466387549 | 0.333333333333 | PPP3CB PPP3R1 PPP3CA | Wnt signaling pathway, calcium modulating pathway |
| GO:0004721 | 0.0494507017216 | 0.444444444444 | PPP3CC PPP3R1 PPP3CA PPP3CB | phosphoprotein phosphatase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RCAN3 | PPP3R1 | 0.981 | 0.896 | bioplex (RCAN3) bioplex_WMM |
| PPP3CC | RCAN3 | 0.958 | 0.863 | bioplex (PPP3CC,RCAN3) bioplex_WMM |
| PPP3CC | RCAN1 | 0.931 | 0.846 | bioplex (PPP3CC,RCAN1) bioplex_WMM |
| PPP3CC | PPP3R1 | 0.929 | 0.845 | bioplex (PPP3CC) bioplex_WMM |
| PPP3CB | RCAN3 | 0.878 | 0.812 | bioplex (RCAN3) bioplex_WMM |
| ARMT1 | RCAN3 | 0.835 | 0.78 | bioplex (RCAN3) bioplex_WMM |
| PPP3CC | PPP3CB | 0.833 | 0.78 | bioplex (PPP3CC) bioplex_WMM |
| PPP3CA | RCAN3 | 0.806 | 0.768 | bioplex (PPP3CA,RCAN3) bioplex_WMM |
| PPP3CA | RCAN1 | 0.574 | 0.657 | bioplex (PPP3CA,RCAN1) bioplex_WMM |
| PPP3CA | PPP3R1 | 0.224 | 0.466 | bioplex (PPP3CA) bioplex_WMM |
| PPP3CB | RCAN1 | 0.215 | 0.464 | bioplex (RCAN1) bioplex_WMM |
| PPP3CC | RCAN2 | 0.099 | 0.359 | bioplex (RCAN2) bioplex_WMM |
| ARMT1 | ARHGDIB | 0.055 | 0.308 | Guru fraction |
| ARMT1 | RCAN1 | 0.05 | 0.296 | bioplex (RCAN1) bioplex_WMM |
| PPP3CB | RCAN2 | 0.05 | 0.295 | bioplex (RCAN2) bioplex_WMM |
| PPP3R1 | RCAN1 | 0.041 | 0.271 | bioplex (RCAN1) bioplex_WMM |
| PPP3CB | PPP3CA | 0.037 | 0.266 | bioplex_WMM gupta_WMM WMM_only |
| PPP3CC | PPP3CA | 0.031 | 0.238 | bioplex_WMM WMM_only |
| PPP3CB | PPP3R1 | 0.026 | 0.219 | bioplex_WMM WMM_only |
| PPP3R1 | RCAN2 | 0.016 | 0.158 | bioplex (RCAN2) bioplex_WMM |
| PPP3CA | RCAN2 | 0.011 | 0.143 | bioplex (RCAN2) bioplex_WMM |
| RCAN3 | RCAN1 | 0.01 | 0.131 | bioplex_WMM WMM_only |
| ARMT1 | PPP3CA | 0.009 | 0.103 | bioplex_WMM Guru fraction |
| ARMT1 | PPP3R1 | 0.008 | 0.043 | bioplex_WMM WMM_only |
| ARMT1 | PPP3CB | 0.008 | 0.031 | bioplex_WMM gupta_WMM WMM_only |
| ARMT1 | PPP3CC | 0.005 | 0.007 | bioplex_WMM Guru fraction |
| ARMT1 | RCAN2 | 0.0 | 0.0 | bioplex (RCAN2) bioplex_WMM |
Images
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Complex HuMAP2_04373 has an average edge precision of 0.409 which is ranked 3206 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RCAN1 | HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |
| PPP3CB | HuMAP2_02758 HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |
| ARHGDIB | HuMAP2_04373 HuMAP2_06203 |
| PPP3CC | HuMAP2_02758 HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |
| RCAN2 | HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |
| PPP3CA | HuMAP2_02758 HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |
| PPP3R1 | HuMAP2_02758 HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |
| ARMT1 | HuMAP2_02758 HuMAP2_04373 HuMAP2_06203 |
| RCAN3 | HuMAP2_02758 HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |