hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04376

Confidence: Very High

Genename	Protein Name	Links
RAD21	Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)]	UniProt NCBI
WAPL	Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor)	UniProt NCBI
SMC1B	Structural maintenance of chromosomes protein 1B (SMC protein 1B) (SMC-1-beta) (SMC-1B)	UniProt NCBI
CDCA5	Sororin (Cell division cycle-associated protein 5) (p35)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0008278	1.20758028692e-08	1.0	CDCA5 RAD21 WAPL SMC1B	cohesin complex
REAC:R-HSA-2468052	2.22736463084e-07	0.75	CDCA5 RAD21 WAPL	Establishment of Sister Chromatid Cohesion
CORUM:5432	7.53895486054e-05	0.5	CDCA5 RAD21	Sororin-cohesin complex
CORUM:1856	7.53895486054e-05	0.5	CDCA5 RAD21	Sororin-cohesin complex
GO:0000793	0.0001570766767	1.0	CDCA5 RAD21 WAPL SMC1B	condensed chromosome
REAC:R-HSA-2500257	0.000377028841718	0.75	CDCA5 RAD21 WAPL	Resolution of Sister Chromatid Cohesion
GO:0007063	0.000413778117181	0.75	CDCA5 RAD21 WAPL	regulation of sister chromatid cohesion
REAC:R-HSA-2470946	0.000452175281072	0.5	RAD21 WAPL	Cohesin Loading onto Chromatin
REAC:R-HSA-1640170	0.000545854331888	1.0	CDCA5 RAD21 WAPL SMC1B	Cell Cycle
GO:0071168	0.000734489509778	0.75	CDCA5 RAD21 WAPL	protein localization to chromatin
REAC:R-HSA-69242	0.000880763368668	0.75	CDCA5 RAD21 WAPL	S Phase
REAC:R-HSA-68884	0.000914071346391	0.5	RAD21 WAPL	Mitotic Telophase/Cytokinesis
REAC:R-HSA-2467813	0.00134455008537	0.75	CDCA5 RAD21 WAPL	Separation of Sister Chromatids
REAC:R-HSA-68877	0.00152914291965	0.75	CDCA5 RAD21 WAPL	Mitotic Prometaphase
REAC:R-HSA-68882	0.00152914291965	0.75	CDCA5 RAD21 WAPL	Mitotic Anaphase
REAC:R-HSA-2555396	0.00155333604228	0.75	CDCA5 RAD21 WAPL	Mitotic Metaphase and Anaphase
GO:0007062	0.0062689516986	0.75	CDCA5 RAD21 WAPL	sister chromatid cohesion
WP:WP179	0.0110921279178	0.5	SMC1B RAD21	Cell Cycle
REAC:R-HSA-68886	0.0117390466083	0.75	CDCA5 RAD21 WAPL	M Phase
KEGG:04110	0.0141554312811	0.5	SMC1B RAD21	Cell cycle
GO:0071922	0.0162267366884	0.5	CDCA5 WAPL	regulation of cohesin loading
GO:0033045	0.0198185309013	0.75	CDCA5 RAD21 WAPL	regulation of sister chromatid segregation
GO:1905634	0.0270421395626	0.5	CDCA5 WAPL	regulation of protein localization to chromatin
GO:0071921	0.0270421395626	0.5	CDCA5 WAPL	cohesin loading
GO:0034502	0.0275320606423	0.75	CDCA5 RAD21 WAPL	protein localization to chromosome
REAC:R-HSA-1221632	0.0277220764292	0.5	SMC1B RAD21	Meiotic synapsis
REAC:R-HSA-69278	0.0299490115235	0.75	CDCA5 RAD21 WAPL	Cell Cycle, Mitotic
GO:0051983	0.0424904593616	0.75	CDCA5 RAD21 WAPL	regulation of chromosome segregation

Edges

Protein 1	Protein 2	Score	Precision	Evidence
RAD21	SMC1B	0.998	0.937	bioplex (RAD21) bioplex_WMM Malo fraction
RAD21	CDCA5	0.988	0.902	hein_WMM bioplex (CDCA5) bioplex_WMM youn_WMM hein (CDCA5,RAD21)
RAD21	WAPL	0.91	0.833	hein_WMM bioplex (RAD21) bioplex_WMM youn_WMM hein (RAD21,WAPL) gupta_WMM boldt_WMM
CDCA5	SMC1B	0.02	0.188	bioplex (CDCA5) bioplex_WMM
SMC1B	WAPL	0.008	0.024	bioplex_WMM WMM_only
CDCA5	WAPL	0.006	0.005	hein_WMM youn_WMM hein (CDCA5) gupta_WMM

Images

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Complex HuMAP2_04376 has an average edge precision of 0.482 which is ranked 2623 out of all 6965 complexes.

Related Complexes

Genename	Complexes
RAD21	HuMAP2_00301 HuMAP2_01398 HuMAP2_04376 HuMAP2_05244
WAPL	HuMAP2_04376 HuMAP2_04736 HuMAP2_05244
SMC1B	HuMAP2_00301 HuMAP2_01398 HuMAP2_04376 HuMAP2_05244
CDCA5	HuMAP2_00301 HuMAP2_01398 HuMAP2_04376 HuMAP2_05244

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04376