hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04384

Confidence: Medium

Genename	Protein Name	Links
ALDH9A1	4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) [Cleaved into: 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed]	UniProt NCBI
TRAK2	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein)	UniProt NCBI
TRAK1	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton)	UniProt NCBI
RHOT1	Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1)	UniProt NCBI
EFHD2	EF-hand domain-containing protein D2 (Swiprosin-1)	UniProt NCBI
SAMHD1	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1)	UniProt NCBI
AXIN1	Axin-1 (Axis inhibition protein 1) (hAxin)	UniProt NCBI
CARD19	Caspase recruitment domain-containing protein 19 (Bcl10-interacting CARD protein) (BinCARD)	UniProt NCBI
GSK3B	Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)	UniProt NCBI
GSK3A	Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)	UniProt NCBI
FRAT1	Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas 1) (FRAT-1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP363	2.26936385762e-06	0.363636363636	GSK3B FRAT1 AXIN1 GSK3A	Wnt Signaling Pathway
REAC:R-HSA-196299	4.44408058631e-05	0.272727272727	GSK3B AXIN1 FRAT1	Beta-catenin phosphorylation cascade
CORUM:177	0.000100616904936	0.181818181818	TRAK2 TRAK1	OGT-TRAK1-TRAK2 complex
CORUM:6352	0.000100616904936	0.181818181818	GSK3B AXIN1	FoxM1-Axin-GSK3beta complex
CORUM:6963	0.000100616904936	0.181818181818	GSK3B AXIN1	AXIN1-GID8-GSK3B complex
CORUM:2998	0.000201152732593	0.181818181818	GSK3B AXIN1	Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex
CORUM:3166	0.000201152732593	0.181818181818	GSK3B AXIN1	AXIN1-APC-CTNNB1-GSK3B complex
CORUM:4151	0.000201152732593	0.181818181818	GSK3B AXIN1	TSC (TSC1, TSC2, AXIN, GSK3) complex
CORUM:6353	0.000201152732593	0.181818181818	GSK3B AXIN1	beta-Catenin destruction complex
CORUM:7159	0.000201152732593	0.181818181818	GSK3B AXIN1	TSC2-GSK3-AXIN-DVL complex
REAC:R-HSA-4641262	0.00026395051014	0.272727272727	GSK3B AXIN1 FRAT1	Disassembly of the destruction complex and recruitment of AXIN to the membrane
WP:WP4336	0.00149665608667	0.272727272727	GSK3B AXIN1 FRAT1	ncRNAs involved in Wnt signaling in hepatocellular carcinoma
WP:WP4258	0.00207769205966	0.272727272727	GSK3B AXIN1 FRAT1	LncRNA involvement in canonical Wnt signaling and colorectal cancer
WP:WP399	0.0028784370899	0.272727272727	GSK3B AXIN1 FRAT1	Wnt Signaling Pathway and Pluripotency
GO:0030877	0.00328477723547	0.272727272727	GSK3B AXIN1 GSK3A	beta-catenin destruction complex
WP:WP710	0.00354513324173	0.272727272727	GSK3B AXIN1 FRAT1	DNA Damage Response (only ATM dependent)
WP:WP428	0.0038593508941	0.272727272727	GSK3B AXIN1 FRAT1	Wnt Signaling
WP:WP3664	0.00453563845182	0.181818181818	GSK3B AXIN1	Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds
KEGG:05224	0.0045884068153	0.272727272727	GSK3B AXIN1 FRAT1	Breast cancer
KEGG:05226	0.00469404907611	0.272727272727	GSK3B AXIN1 FRAT1	Gastric cancer
HPA:007030_22	0.00535958773726	0.636363636364	AXIN1 ALDH9A1 TRAK1 FRAT1 GSK3A GSK3B CARD19	cerebellum; cells in molecular layer[Approved,Medium]
REAC:R-HSA-195253	0.00563793437463	0.272727272727	GSK3B AXIN1 FRAT1	Degradation of beta-catenin by the destruction complex
WP:WP3872	0.00632889780883	0.181818181818	GSK3B GSK3A	Regulation of Apoptosis by Parathyroid Hormone-related Protein
KEGG:04310	0.00660649288056	0.272727272727	GSK3B AXIN1 FRAT1	Wnt signaling pathway
GO:0047497	0.00678530576901	0.272727272727	TRAK2 RHOT1 TRAK1	mitochondrion transport along microtubule
GO:0034643	0.00678530576901	0.272727272727	TRAK2 RHOT1 TRAK1	establishment of mitochondrion localization, microtubule-mediated
KEGG:05225	0.00833255140444	0.272727272727	GSK3B AXIN1 FRAT1	Hepatocellular carcinoma
WP:WP4262	0.00840680869637	0.272727272727	GSK3B AXIN1 FRAT1	Breast cancer pathway
WP:WP2583	0.00841724495641	0.181818181818	GSK3B GSK3A	T-Cell Receptor and Co-stimulatory Signaling
REAC:R-HSA-5467340	0.00984862364944	0.181818181818	GSK3B AXIN1	AXIN missense mutants destabilize the destruction complex
REAC:R-HSA-5467348	0.00984862364944	0.181818181818	GSK3B AXIN1	Truncations of AMER1 destabilize the destruction complex
REAC:R-HSA-4839744	0.00984862364944	0.181818181818	GSK3B AXIN1	truncated APC mutants destabilize the destruction complex
REAC:R-HSA-198323	0.00984862364944	0.181818181818	GSK3B GSK3A	AKT phosphorylates targets in the cytosol
REAC:R-HSA-4839748	0.00984862364944	0.181818181818	GSK3B AXIN1	AMER1 mutants destabilize the destruction complex
REAC:R-HSA-5467337	0.00984862364944	0.181818181818	GSK3B AXIN1	APC truncation mutants have impaired AXIN binding
REAC:R-HSA-4839735	0.00984862364944	0.181818181818	GSK3B AXIN1	AXIN mutants destabilize the destruction complex, activating WNT signaling
GO:0051654	0.0101325037368	0.272727272727	TRAK2 RHOT1 TRAK1	establishment of mitochondrion localization
REAC:R-HSA-5339716	0.0113592180397	0.181818181818	GSK3B AXIN1	Misspliced GSK3beta mutants stabilize beta-catenin
REAC:R-HSA-5358751	0.0113592180397	0.181818181818	GSK3B AXIN1	S45 mutants of beta-catenin aren't phosphorylated
REAC:R-HSA-5358752	0.0113592180397	0.181818181818	GSK3B AXIN1	T41 mutants of beta-catenin aren't phosphorylated
REAC:R-HSA-4839743	0.0113592180397	0.181818181818	GSK3B AXIN1	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REAC:R-HSA-5358747	0.0113592180397	0.181818181818	GSK3B AXIN1	S33 mutants of beta-catenin aren't phosphorylated
REAC:R-HSA-5358749	0.0113592180397	0.181818181818	GSK3B AXIN1	S37 mutants of beta-catenin aren't phosphorylated
REAC:R-HSA-5663202	0.0164313806603	0.363636363636	TRAK1 GSK3B AXIN1 GSK3A	Diseases of signal transduction
GO:1904886	0.0169663110948	0.272727272727	GSK3B AXIN1 FRAT1	beta-catenin destruction complex disassembly
WP:WP127	0.0232476784257	0.181818181818	GSK3B GSK3A	IL-5 Signaling Pathway
WP:WP500	0.0232476784257	0.181818181818	GSK3B GSK3A	Glycogen Synthesis and Degradation
HPA:007030_23	0.024766671272	0.363636363636	TRAK1 GSK3B AXIN1 GSK3A	cerebellum; cells in molecular layer[Approved,High]
GO:2000077	0.0247952876258	0.181818181818	GSK3B GSK3A	negative regulation of type B pancreatic cell development
GO:0098957	0.0247952876258	0.181818181818	TRAK2 TRAK1	anterograde axonal transport of mitochondrion
REAC:R-HSA-5674400	0.032324384664	0.181818181818	GSK3B GSK3A	Constitutive Signaling by AKT1 E17K in Cancer
KEGG:05217	0.0336601657666	0.181818181818	GSK3B AXIN1	Basal cell carcinoma
KEGG:05213	0.0348701171702	0.181818181818	GSK3B AXIN1	Endometrial cancer
HPA:043030_22	0.0354033391457	0.636363636364	AXIN1 ALDH9A1 TRAK1 FRAT1 GSK3A GSK3B CARD19	skin 1; keratinocytes[Approved,Medium]
HPA:007010_23	0.0425498574478	0.454545454545	TRAK1 GSK3A FRAT1 AXIN1 CARD19	cerebellum; Purkinje cells[Approved,High]
HPA:050010_22	0.0464835237945	0.545454545455	AXIN1 ALDH9A1 TRAK1 FRAT1 GSK3A CARD19	spleen; cells in red pulp[Approved,Medium]
REAC:R-HSA-4791275	0.0467760136448	0.181818181818	GSK3B AXIN1	Signaling by WNT in cancer

Edges

Protein 1	Protein 2	Score	Precision	Evidence
TRAK2	TRAK1	0.991	0.909	bioplex (TRAK2) bioplex_WMM
CARD19	TRAK2	0.801	0.766	bioplex (TRAK2) bioplex_WMM
TRAK2	GSK3B	0.489	0.617	bioplex (TRAK2) bioplex_WMM
TRAK2	GSK3A	0.386	0.551	bioplex (TRAK2) bioplex_WMM gupta_WMM
TRAK2	RHOT1	0.198	0.45	bioplex (TRAK2) bioplex_WMM
GSK3B	FRAT1	0.089	0.353	hein_WMM hein (FRAT1)
GSK3A	EFHD2	0.07	0.348	youn_WMM gupta_WMM fraction
FRAT1	GSK3A	0.062	0.344	hein_WMM hein (FRAT1)
ALDH9A1	EFHD2	0.041	0.269	bioplex_WMM youn_WMM fraction
AXIN1	GSK3B	0.04	0.267	hein_WMM hein (AXIN1,GSK3B) gupta_WMM
SAMHD1	GSK3B	0.031	0.238	bioplex (SAMHD1) bioplex_WMM youn_WMM fraction
SAMHD1	GSK3A	0.025	0.216	bioplex (SAMHD1) bioplex_WMM youn_WMM
AXIN1	GSK3A	0.015	0.146	hein_WMM hein (GSK3A)
GSK3B	GSK3A	0.012	0.148	hein_WMM bioplex_WMM youn_WMM fraction
CARD19	TRAK1	0.009	0.097	bioplex_WMM WMM_only
TRAK1	GSK3A	0.008	0.092	bioplex_WMM WMM_only
TRAK1	GSK3B	0.008	0.035	bioplex_WMM WMM_only
TRAK1	RHOT1	0.008	0.024	bioplex_WMM WMM_only
CARD19	GSK3A	0.007	0.006	bioplex_WMM WMM_only
SAMHD1	EFHD2	0.007	0.005	bioplex_WMM youn_WMM WMM_only
GSK3B	EFHD2	0.007	0.002	youn_WMM gupta_WMM WMM_only
SAMHD1	ALDH9A1	0.007	0.001	bioplex_WMM youn_WMM WMM_only
ALDH9A1	GSK3B	0.007	0.001	bioplex_WMM WMM_only
AXIN1	EFHD2	0.007	0.001	gupta_WMM WMM_only
TRAK2	EFHD2	0.007	0.001	gupta_WMM WMM_only
RHOT1	EFHD2	0.007	0.001	youn_WMM WMM_only
CARD19	GSK3B	0.007	0.001	bioplex_WMM WMM_only
CARD19	ALDH9A1	0.007	0.003	bioplex_WMM WMM_only
CARD19	RHOT1	0.007	0.004	bioplex_WMM WMM_only
CARD19	EFHD2	0.007	0.003	bioplex_WMM WMM_only
RHOT1	GSK3A	0.007	0.006	bioplex_WMM youn_WMM WMM_only
GSK3B	RHOT1	0.006	0.005	bioplex_WMM youn_WMM WMM_only
SAMHD1	TRAK2	0.005	0.012	bioplex (TRAK2)
SAMHD1	RHOT1	0.003	0.007	bioplex_WMM youn_WMM WMM_only
ALDH9A1	GSK3A	0.0	0.002	fraction

Images

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Complex HuMAP2_04384 has an average edge precision of 0.169 which is ranked 6536 out of all 6965 complexes.

Related Complexes

Genename	Complexes
ALDH9A1	HuMAP2_00783 HuMAP2_04384 HuMAP2_04578 HuMAP2_05032 HuMAP2_05568
TRAK2	HuMAP2_01016 HuMAP2_01718 HuMAP2_03894 HuMAP2_04384
TRAK1	HuMAP2_01016 HuMAP2_01718 HuMAP2_03894 HuMAP2_04384
RHOT1	HuMAP2_01718 HuMAP2_03894 HuMAP2_04384 HuMAP2_05277
EFHD2	HuMAP2_04384 HuMAP2_04578 HuMAP2_05032 HuMAP2_05568 HuMAP2_05655 HuMAP2_05739
SAMHD1	HuMAP2_00609 HuMAP2_02723 HuMAP2_03296 HuMAP2_04384 HuMAP2_05903
AXIN1	HuMAP2_00965 HuMAP2_02771 HuMAP2_04332 HuMAP2_04384 HuMAP2_04643 HuMAP2_05355 HuMAP2_06022 HuMAP2_06340
CARD19	HuMAP2_00654 HuMAP2_01011 HuMAP2_01016 HuMAP2_01309 HuMAP2_02736 HuMAP2_03894 HuMAP2_04384 HuMAP2_04962
GSK3B	HuMAP2_01568 HuMAP2_01718 HuMAP2_04384
GSK3A	HuMAP2_04384 HuMAP2_04578
FRAT1	HuMAP2_01568 HuMAP2_04384 HuMAP2_04578

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04384