hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04397

Confidence: Medium

Genename	Protein Name	Links
SLC1A3	Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3)	UniProt NCBI
ACSL3	Long-chain-fatty-acid--CoA ligase 3 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 3) (LACS 3)	UniProt NCBI
LNPK	Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark)	UniProt NCBI
CPT2	Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II)	UniProt NCBI
ATP12A	Potassium-transporting ATPase alpha chain 2 (EC 7.2.2.19) (Non-gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)	UniProt NCBI
SYNPR	Synaptoporin	UniProt NCBI
TM9SF2	Transmembrane 9 superfamily member 2 (p76)	UniProt NCBI
FADS2	Acyl-CoA 6-desaturase (EC 1.14.19.3) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) (Fatty acid desaturase 2)	UniProt NCBI
ATP1A3	Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3)	UniProt NCBI
ATP1B3	Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:01212	0.000241189244352	0.3	ACSL3 FADS2 CPT2	Fatty acid metabolism
WP:WP3942	0.000528977866642	0.3	ACSL3 FADS2 CPT2	PPAR signaling pathway
KEGG:03320	0.000584726257012	0.3	ACSL3 FADS2 CPT2	PPAR signaling pathway
REAC:R-HSA-936837	0.000728001600925	0.3	ATP1A3 ATP12A ATP1B3	Ion transport by P-type ATPases
GO:0005391	0.000913516286731	0.3	ATP1A3 ATP12A ATP1B3	sodium:potassium-exchanging ATPase activity
GO:0008556	0.000913516286731	0.3	ATP1A3 ATP12A ATP1B3	potassium transmembrane transporter activity, phosphorylative mechanism
GO:0090533	0.00130456308183	0.3	ATP1A3 ATP12A ATP1B3	cation-transporting ATPase complex
GO:0030007	0.00130456308183	0.3	ATP1A3 ATP12A ATP1B3	cellular potassium ion homeostasis
GO:0008554	0.00130456308183	0.3	ATP1A3 ATP12A ATP1B3	sodium transmembrane transporter activity, phosphorylative mechanism
GO:0036376	0.00179314168727	0.3	ATP1A3 ATP12A ATP1B3	sodium ion export across plasma membrane
GO:0006883	0.00310592047764	0.3	ATP1A3 ATP12A ATP1B3	cellular sodium ion homeostasis
WP:WP368	0.00342603522307	0.2	ACSL3 CPT2	Mitochondrial LC-Fatty Acid Beta-Oxidation
KEGG:04964	0.00368246782768	0.2	ATP1A3 ATP1B3	Proximal tubule bicarbonate reclamation
GO:0098533	0.00607509040552	0.3	ATP1A3 ATP12A ATP1B3	ATPase dependent transmembrane transport complex
KEGG:04960	0.00897691057192	0.2	ATP1A3 ATP1B3	Aldosterone-regulated sodium reabsorption
GO:0098739	0.00917710278923	0.4	ATP1A3 ATP1B3 SLC1A3 ATP12A	import across plasma membrane
WP:WP143	0.0140465886183	0.2	ACSL3 CPT2	Fatty Acid Beta Oxidation
GO:0055075	0.0144029117203	0.3	ATP1A3 ATP12A ATP1B3	potassium ion homeostasis
KEGG:04973	0.0150095691377	0.2	ATP1A3 ATP1B3	Carbohydrate digestion and absorption
KEGG:00071	0.0165563875019	0.2	ACSL3 CPT2	Fatty acid degradation
KEGG:04978	0.0198737758517	0.2	ATP1A3 ATP1B3	Mineral absorption
KEGG:04961	0.02348841544	0.2	ATP1A3 ATP1B3	Endocrine and other factor-regulated calcium reabsorption
REAC:R-HSA-8978868	0.0253102142701	0.3	ACSL3 FADS2 CPT2	Fatty acid metabolism
GO:0015081	0.0275501353781	0.4	ATP1A3 ATP1B3 SLC1A3 ATP12A	sodium ion transmembrane transporter activity
REAC:R-HSA-983712	0.028898887405	0.3	ATP1A3 ATP12A ATP1B3	Ion channel transport
KEGG:04976	0.0294648827991	0.2	ATP1A3 ATP1B3	Bile secretion
GO:0055078	0.0316085885479	0.3	ATP1A3 ATP12A ATP1B3	sodium ion homeostasis
KEGG:04971	0.0349507932285	0.2	ATP1A3 ATP1B3	Gastric acid secretion
KEGG:04918	0.043398064759	0.2	ATP1A3 ATP1B3	Thyroid hormone synthesis
GO:0015662	0.0438273782088	0.3	ATP1A3 ATP12A ATP1B3	ion transmembrane transporter activity, phosphorylative mechanism
KEGG:04911	0.0486244852839	0.2	ATP1A3 ATP1B3	Insulin secretion

Edges

Protein 1	Protein 2	Score	Precision	Evidence
ATP1A3	ATP1B3	0.228	0.468	bioplex (ATP1B3) bioplex_WMM Guru boldt fraction boldt_WMM
LNPK	ATP1B3	0.205	0.454	bioplex (ATP1B3) bioplex_WMM boldt gupta_WMM boldt_WMM
TM9SF2	ATP1B3	0.072	0.354	bioplex (ATP1B3) bioplex_WMM boldt gupta_WMM boldt_WMM
ATP12A	ATP1B3	0.033	0.248	bioplex (ATP1B3) bioplex_WMM boldt_WMM
LNPK	SYNPR	0.03	0.231	bioplex (SYNPR) bioplex_WMM
FADS2	ATP1B3	0.029	0.23	bioplex (ATP1B3) bioplex_WMM gupta_WMM
CPT2	ATP1B3	0.026	0.221	bioplex_WMM fraction boldt_WMM
ACSL3	ATP1B3	0.025	0.215	bioplex (ATP1B3) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
SLC1A3	ATP1B3	0.02	0.185	bioplex (ATP1B3) bioplex_WMM boldt gupta_WMM boldt_WMM
LNPK	TM9SF2	0.007	0.002	bioplex_WMM boldt gupta_WMM boldt_WMM
SLC1A3	LNPK	0.007	0.004	bioplex_WMM boldt gupta_WMM boldt_WMM
CPT2	TM9SF2	0.006	0.004	bioplex_WMM WMM_only
CPT2	ACSL3	0.006	0.007	bioplex_WMM WMM_only boldt_WMM
CPT2	SLC1A3	0.006	0.011	bioplex_WMM WMM_only
LNPK	ACSL3	0.006	0.009	bioplex_WMM youn_WMM gupta_WMM WMM_only
CPT2	ATP12A	0.005	0.013	bioplex_WMM youn_WMM WMM_only
FADS2	LNPK	0.005	0.007	bioplex_WMM youn_WMM gupta_WMM WMM_only
SLC1A3	TM9SF2	0.005	0.017	bioplex_WMM boldt gupta_WMM boldt_WMM
LNPK	ATP12A	0.005	0.013	bioplex_WMM WMM_only
CPT2	ATP1A3	0.004	0.01	bioplex_WMM WMM_only
SLC1A3	ACSL3	0.004	0.005	bioplex_WMM youn_WMM gupta_WMM WMM_only
TM9SF2	ATP12A	0.004	0.011	bioplex_WMM WMM_only
FADS2	TM9SF2	0.004	0.015	bioplex_WMM gupta_WMM WMM_only
ATP1A3	LNPK	0.004	0.008	bioplex_WMM WMM_only
SLC1A3	FADS2	0.004	0.017	bioplex_WMM youn_WMM gupta_WMM WMM_only
ACSL3	TM9SF2	0.003	0.012	bioplex_WMM gupta_WMM WMM_only
SLC1A3	ATP12A	0.003	0.008	bioplex_WMM WMM_only boldt_WMM
FADS2	ATP12A	0.003	0.015	bioplex_WMM WMM_only
FADS2	ACSL3	0.003	0.015	bioplex_WMM youn_WMM gupta_WMM WMM_only
ACSL3	ATP12A	0.003	0.017	bioplex_WMM WMM_only
ATP1A3	TM9SF2	0.0	0.008	bioplex_WMM WMM_only
SLC1A3	ATP1A3	0.0	0.009	bioplex_WMM boldt boldt_WMM
ATP1A3	ACSL3	0.0	0.014	bioplex_WMM gupta_WMM WMM_only
FADS2	ATP1A3	0.0	0.011	bioplex_WMM WMM_only
CPT2	FADS2	0.0	0.012	bioplex_WMM fraction
ATP1A3	ATP12A	0.0	0.008	bioplex_WMM WMM_only

Images

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Complex HuMAP2_04397 has an average edge precision of 0.08 which is ranked 6962 out of all 6965 complexes.

Related Complexes

Genename	Complexes
SLC1A3	HuMAP2_00092 HuMAP2_00181 HuMAP2_01814 HuMAP2_02264 HuMAP2_04397
ACSL3	HuMAP2_03665 HuMAP2_04397
LNPK	HuMAP2_02369 HuMAP2_04397 HuMAP2_05574
CPT2	HuMAP2_00062 HuMAP2_00774 HuMAP2_04397
ATP12A	HuMAP2_04397
SYNPR	HuMAP2_02369 HuMAP2_04397
TM9SF2	HuMAP2_04397 HuMAP2_05574
FADS2	HuMAP2_02201 HuMAP2_04397
ATP1A3	HuMAP2_04397 HuMAP2_04475 HuMAP2_05574
ATP1B3	HuMAP2_04397 HuMAP2_05574 HuMAP2_05916

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04397