hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04398
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) | UniProt NCBI |
| ORC6 | Origin recognition complex subunit 6 | UniProt NCBI |
| ORC2 | Origin recognition complex subunit 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000808 | 5.08584025729e-06 | 1.0 | ORC2 LRWD1 ORC6 | origin recognition complex |
| GO:0005664 | 5.08584025729e-06 | 1.0 | ORC2 LRWD1 ORC6 | nuclear origin of replication recognition complex |
| CORUM:5251 | 5.03310689057e-05 | 0.666666666667 | ORC2 ORC6 | Ku-ORC complex |
| CORUM:1033 | 5.03310689057e-05 | 0.666666666667 | ORC2 ORC6 | ORC complex (origin recognition complex) |
| CORUM:1031 | 5.03310689057e-05 | 0.666666666667 | ORC2 ORC6 | ORC complex (origin recognition complex) |
| CORUM:389 | 5.03310689057e-05 | 0.666666666667 | ORC2 ORC6 | ORC complex (origin recognition complex) |
| REAC:R-HSA-68616 | 0.000100412974104 | 0.666666666667 | ORC2 ORC6 | Assembly of the ORC complex at the origin of replication |
| REAC:R-HSA-113507 | 0.000240958766872 | 0.666666666667 | ORC2 ORC6 | E2F-enabled inhibition of pre-replication complex formation |
| REAC:R-HSA-68689 | 0.000368098478948 | 0.666666666667 | ORC2 ORC6 | CDC6 association with the ORC:origin complex |
| GO:0006270 | 0.000368723418654 | 1.0 | ORC2 LRWD1 ORC6 | DNA replication initiation |
| WP:WP466 | 0.000824391260345 | 0.666666666667 | ORC2 ORC6 | DNA Replication |
| REAC:R-HSA-113510 | 0.00154525199441 | 0.666666666667 | ORC2 ORC6 | E2F mediated regulation of DNA replication |
| WP:WP45 | 0.00186819955626 | 0.666666666667 | ORC2 ORC6 | G1 to S cell cycle control |
| KEGG:04110 | 0.00318067102449 | 0.666666666667 | ORC2 ORC6 | Cell cycle |
| REAC:R-HSA-68962 | 0.00353026371942 | 0.666666666667 | ORC2 ORC6 | Activation of the pre-replicative complex |
| REAC:R-HSA-176187 | 0.00445214779833 | 0.666666666667 | ORC2 ORC6 | Activation of ATR in response to replication stress |
| WP:WP179 | 0.00636520475825 | 0.666666666667 | ORC2 ORC6 | Cell Cycle |
| REAC:R-HSA-68827 | 0.011426592715 | 0.666666666667 | ORC2 ORC6 | CDT1 association with the CDC6:ORC:origin complex |
| REAC:R-HSA-68867 | 0.015207050821 | 0.666666666667 | ORC2 ORC6 | Assembly of the pre-replicative complex |
| REAC:R-HSA-68949 | 0.0165866686159 | 0.666666666667 | ORC2 ORC6 | Orc1 removal from chromatin |
| REAC:R-HSA-69002 | 0.0238137546255 | 0.666666666667 | ORC2 ORC6 | DNA Replication Pre-Initiation |
| REAC:R-HSA-69052 | 0.0261170593829 | 0.666666666667 | ORC2 ORC6 | Switching of origins to a post-replicative state |
| GO:0006261 | 0.0302766427817 | 1.0 | ORC2 LRWD1 ORC6 | DNA-dependent DNA replication |
| REAC:R-HSA-69239 | 0.0459783176444 | 0.666666666667 | ORC2 ORC6 | Synthesis of DNA |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LRWD1 | ORC2 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (LRWD1,ORC2) Malo gupta_WMM fraction |
| ORC6 | ORC2 | 0.702 | 0.723 | bioplex (ORC6) bioplex_WMM |
| LRWD1 | ORC6 | 0.02 | 0.188 | bioplex (ORC6) bioplex_WMM |
Images
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Complex HuMAP2_04398 has an average edge precision of 0.62 which is ranked 1835 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LRWD1 | HuMAP2_00864 HuMAP2_02551 HuMAP2_04398 HuMAP2_04533 |
| ORC6 | HuMAP2_00864 HuMAP2_02994 HuMAP2_04398 HuMAP2_04533 |
| ORC2 | HuMAP2_00864 HuMAP2_02994 HuMAP2_04398 HuMAP2_04533 HuMAP2_04597 |