hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04412
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| OPTN | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | UniProt NCBI |
| STX10 | Syntaxin-10 (Syn10) | UniProt NCBI |
| VAMP8 | Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB) | UniProt NCBI |
| STX12 | Syntaxin-12 | UniProt NCBI |
| VTI1A | Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04130 | 4.27757362181e-06 | 0.6 | VTI1A VAMP8 STX10 | SNARE interactions in vesicular transport |
| GO:0031201 | 1.98600319243e-05 | 0.8 | VTI1A STX10 VAMP8 STX12 | SNARE complex |
| REAC:R-HSA-199991 | 0.00166286547268 | 0.8 | VTI1A OPTN VAMP8 STX10 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0020580612036 | 0.8 | VTI1A OPTN VAMP8 STX10 | Vesicle-mediated transport |
| GO:0005484 | 0.00367721278555 | 0.6 | VTI1A STX12 STX10 | SNAP receptor activity |
| REAC:R-HSA-6811440 | 0.0145030354259 | 0.4 | STX10 VTI1A | Retrograde transport at the Trans-Golgi-Network |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| STX12 | OPTN | 0.974 | 0.886 | bioplex (STX12) bioplex_WMM youn_WMM |
| STX12 | STX10 | 0.894 | 0.82 | bioplex (STX12) bioplex_WMM gupta_WMM |
| STX12 | VTI1A | 0.744 | 0.74 | bioplex (STX12) bioplex_WMM gupta_WMM |
| STX12 | VAMP8 | 0.711 | 0.728 | bioplex (STX12) bioplex_WMM gupta_WMM |
| VTI1A | STX10 | 0.015 | 0.14 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| VTI1A | VAMP8 | 0.012 | 0.144 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| VAMP8 | STX10 | 0.012 | 0.15 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| VTI1A | OPTN | 0.008 | 0.025 | bioplex_WMM WMM_only |
| VAMP8 | OPTN | 0.007 | 0.005 | bioplex_WMM WMM_only |
| STX10 | OPTN | 0.007 | 0.007 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04412 has an average edge precision of 0.364 which is ranked 3695 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| OPTN | HuMAP2_04257 HuMAP2_04412 |
| STX10 | HuMAP2_00576 HuMAP2_00644 HuMAP2_04412 HuMAP2_04951 |
| VAMP8 | HuMAP2_00576 HuMAP2_00644 HuMAP2_02881 HuMAP2_04322 HuMAP2_04412 |
| STX12 | HuMAP2_00576 HuMAP2_00644 HuMAP2_04412 |
| VTI1A | HuMAP2_00576 HuMAP2_00644 HuMAP2_04412 |