hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04424
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NDUFV3 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) (Renal carcinoma antigen NY-REN-4) | UniProt NCBI |
| NDUFA8 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit) | UniProt NCBI |
| NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (Complex I-MWFE) (CI-MWFE) (NADH-ubiquinone oxidoreductase MWFE subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4324 | 1.50887656874e-06 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Mitochondrial complex I assembly model OXPHOS system |
| CORUM:178 | 2.22651992831e-06 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Respiratory chain complex I (holoenzyme), mitochondrial |
| KEGG:00190 | 8.02679835688e-06 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Oxidative phosphorylation |
| WP:WP111 | 8.35827186966e-06 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Electron Transport Chain (OXPHOS system in mitochondria) |
| KEGG:05012 | 9.78855844223e-06 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Parkinson disease |
| REAC:R-HSA-6799198 | 9.93609173322e-06 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Complex I biogenesis |
| KEGG:04723 | 1.12669164546e-05 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Retrograde endocannabinoid signaling |
| KEGG:04932 | 1.15269222189e-05 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Non-alcoholic fatty liver disease (NAFLD) |
| KEGG:05010 | 1.79503216233e-05 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Alzheimer disease |
| KEGG:05016 | 2.6860646392e-05 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Huntington disease |
| WP:WP4396 | 2.70021017308e-05 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Nonalcoholic fatty liver disease |
| KEGG:04714 | 4.51020686166e-05 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Thermogenesis |
| REAC:R-HSA-611105 | 6.02657683388e-05 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Respiratory electron transport |
| REAC:R-HSA-163200 | 0.000113954833063 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| CORUM:2919 | 0.000150966163965 | 0.666666666667 | NDUFA8 NDUFA1 | Respiratory chain complex I (gamma subunit) mitochondrial |
| REAC:R-HSA-1428517 | 0.000330512177188 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0003954 | 0.000766145507331 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | NADH dehydrogenase activity |
| GO:0008137 | 0.000766145507331 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | NADH dehydrogenase (ubiquinone) activity |
| GO:0050136 | 0.000766145507331 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | NADH dehydrogenase (quinone) activity |
| GO:0005747 | 0.00120280122085 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | mitochondrial respiratory chain complex I |
| GO:0030964 | 0.00120280122085 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | NADH dehydrogenase complex |
| GO:0045271 | 0.00120280122085 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | respiratory chain complex I |
| GO:0006120 | 0.00128871559377 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | mitochondrial electron transport, NADH to ubiquinone |
| WP:WP623 | 0.00142103052979 | 0.666666666667 | NDUFA8 NDUFV3 | Oxidative phosphorylation |
| GO:0016655 | 0.00200709053011 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| GO:0032981 | 0.00326856055107 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | mitochondrial respiratory chain complex I assembly |
| GO:0010257 | 0.00326856055107 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | NADH dehydrogenase complex assembly |
| GO:0098803 | 0.00455146375597 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | respiratory chain complex |
| GO:0005746 | 0.00475834847216 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | mitochondrial respirasome |
| GO:0070469 | 0.00564855215433 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | respirasome |
| GO:0042775 | 0.00690911398953 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 0.00718184217333 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | ATP synthesis coupled electron transport |
| GO:0016651 | 0.00929437307021 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | oxidoreductase activity, acting on NAD(P)H |
| GO:1990204 | 0.00996606725847 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | oxidoreductase complex |
| KEGG:01100 | 0.0105851300972 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | Metabolic pathways |
| GO:0033108 | 0.0106693663112 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | mitochondrial respiratory chain complex assembly |
| GO:0022904 | 0.0110330947082 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | respiratory electron transport chain |
| GO:0022900 | 0.011404996777 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | electron transport chain |
| GO:0098800 | 0.0218385980648 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | inner mitochondrial membrane protein complex |
| GO:0006119 | 0.0248678516681 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | oxidative phosphorylation |
| GO:0045333 | 0.0442598881134 | 1.0 | NDUFA8 NDUFV3 NDUFA1 | cellular respiration |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NDUFV3 | NDUFA8 | 0.856 | 0.793 | bioplex (NDUFA8) bioplex_WMM |
| NDUFA8 | NDUFA1 | 0.549 | 0.643 | bioplex (NDUFA8) bioplex_WMM |
| NDUFV3 | NDUFA1 | 0.01 | 0.121 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04424 has an average edge precision of 0.519 which is ranked 2396 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NDUFV3 | HuMAP2_00273 HuMAP2_01373 HuMAP2_01573 HuMAP2_01600 HuMAP2_04424 HuMAP2_05114 |
| NDUFA8 | HuMAP2_00273 HuMAP2_01373 HuMAP2_01573 HuMAP2_01600 HuMAP2_02247 HuMAP2_04424 HuMAP2_05114 HuMAP2_05273 HuMAP2_05924 |
| NDUFA1 | HuMAP2_01573 HuMAP2_04424 HuMAP2_05273 HuMAP2_05924 |