hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04425
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ZRSR2 | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP) | UniProt NCBI |
| RNPC3 | RNA-binding region-containing protein 3 (RNA-binding motif protein 40) (RNA-binding protein 40) (U11/U12 small nuclear ribonucleoprotein 65 kDa protein) (U11/U12 snRNP 65 kDa protein) (U11/U12-65K) | UniProt NCBI |
| SNRNP35 | U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12 snRNP 35 kDa protein) (U11/U12-35K) (Protein HM-1) (U1 snRNP-binding protein homolog) | UniProt NCBI |
| SNRNP48 | U11/U12 small nuclear ribonucleoprotein 48 kDa protein (U11/U12 snRNP 48 kDa protein) (U11/U12-48K) | UniProt NCBI |
| DENND4B | DENN domain-containing protein 4B | UniProt NCBI |
| PDCD7 | Programmed cell death protein 7 (ES18) (hES18) | UniProt NCBI |
| ZMAT5 | Zinc finger matrin-type protein 5 (U11/U12 small nuclear ribonucleoprotein 20 kDa protein) (U11/U12 snRNP 20 kDa protein) (U11/U12-20K) | UniProt NCBI |
| TTC33 | Tetratricopeptide repeat protein 33 (TPR repeat protein 33) (Osmosis-responsive factor) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:430 | 1.14957593036e-14 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | 18S U11/U12 snRNP |
| REAC:R-HSA-72165 | 6.63779124038e-12 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | mRNA Splicing - Minor Pathway |
| GO:0005689 | 1.63341960744e-11 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | U12-type spliceosomal complex |
| REAC:R-HSA-72172 | 1.70178350728e-08 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | mRNA Splicing |
| REAC:R-HSA-72203 | 7.00146969385e-08 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0005681 | 1.99864802897e-06 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | spliceosomal complex |
| CORUM:1068 | 2.13617832454e-06 | 0.375 | SNRNP48 SNRNP35 PDCD7 | 12S U11 snRNP |
| REAC:R-HSA-8953854 | 3.16815271587e-05 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | Metabolism of RNA |
| GO:0000377 | 0.000108889381157 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.000108889381157 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.000115337312222 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | RNA splicing, via transesterification reactions |
| GO:0008380 | 0.000303124403181 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | RNA splicing |
| GO:0006397 | 0.000469384667037 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | mRNA processing |
| GO:0016071 | 0.0151982958681 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | mRNA metabolic process |
| GO:1990904 | 0.0210101725439 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | ribonucleoprotein complex |
| GO:0006396 | 0.0243548281027 | 0.75 | PDCD7 SNRNP35 RNPC3 ZRSR2 SNRNP48 ZMAT5 | RNA processing |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ZRSR2 | ZMAT5 | 0.995 | 0.923 | bioplex (ZRSR2) bioplex_WMM |
| ZRSR2 | SNRNP35 | 0.989 | 0.905 | bioplex (ZRSR2) bioplex_WMM |
| ZRSR2 | RNPC3 | 0.824 | 0.773 | bioplex (ZRSR2) bioplex_WMM |
| ZRSR2 | SNRNP48 | 0.571 | 0.655 | bioplex (ZRSR2) bioplex_WMM |
| ZRSR2 | PDCD7 | 0.5 | 0.621 | bioplex (ZRSR2) bioplex_WMM |
| ZMAT5 | DENND4B | 0.135 | 0.406 | bioplex (ZMAT5) bioplex_WMM |
| PDCD7 | ZMAT5 | 0.082 | 0.351 | bioplex (ZMAT5) bioplex_WMM |
| SNRNP35 | RNPC3 | 0.063 | 0.347 | bioplex (SNRNP35) bioplex_WMM youn_WMM |
| PDCD7 | SNRNP35 | 0.057 | 0.323 | bioplex (SNRNP35) bioplex_WMM youn_WMM |
| TTC33 | ZRSR2 | 0.055 | 0.311 | bioplex (ZRSR2) bioplex_WMM |
| ZMAT5 | RNPC3 | 0.054 | 0.299 | bioplex (ZMAT5) bioplex_WMM |
| SNRNP35 | ZMAT5 | 0.051 | 0.301 | bioplex (ZMAT5) bioplex_WMM |
| SNRNP48 | ZMAT5 | 0.04 | 0.269 | bioplex (ZMAT5) bioplex_WMM |
| SNRNP48 | PDCD7 | 0.03 | 0.232 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
| PDCD7 | RNPC3 | 0.026 | 0.215 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
| SNRNP48 | RNPC3 | 0.025 | 0.213 | bioplex_WMM youn_WMM WMM_only |
| SNRNP48 | SNRNP35 | 0.024 | 0.214 | bioplex (SNRNP35) bioplex_WMM youn_WMM |
| SNRNP48 | DENND4B | 0.008 | 0.06 | bioplex_WMM WMM_only |
| PDCD7 | DENND4B | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SNRNP35 | DENND4B | 0.008 | 0.06 | bioplex_WMM WMM_only |
| RNPC3 | DENND4B | 0.008 | 0.046 | bioplex_WMM WMM_only |
| TTC33 | ZMAT5 | 0.008 | 0.035 | bioplex_WMM WMM_only |
| TTC33 | PDCD7 | 0.008 | 0.033 | bioplex_WMM WMM_only |
| TTC33 | SNRNP48 | 0.008 | 0.033 | bioplex_WMM WMM_only |
| TTC33 | SNRNP35 | 0.008 | 0.031 | bioplex_WMM WMM_only |
| TTC33 | RNPC3 | 0.008 | 0.012 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04425 has an average edge precision of 0.297 which is ranked 4635 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ZRSR2 | HuMAP2_01062 HuMAP2_01898 HuMAP2_02518 HuMAP2_04425 HuMAP2_05278 |
| RNPC3 | HuMAP2_01062 HuMAP2_02518 HuMAP2_04425 HuMAP2_05278 |
| SNRNP35 | HuMAP2_01062 HuMAP2_02518 HuMAP2_04425 HuMAP2_05278 |
| SNRNP48 | HuMAP2_01062 HuMAP2_02518 HuMAP2_04425 |
| DENND4B | HuMAP2_01062 HuMAP2_02518 HuMAP2_04425 |
| PDCD7 | HuMAP2_01062 HuMAP2_02518 HuMAP2_04425 |
| ZMAT5 | HuMAP2_01062 HuMAP2_02518 HuMAP2_04425 HuMAP2_05278 |
| TTC33 | HuMAP2_00334 HuMAP2_01062 HuMAP2_04425 HuMAP2_06871 |