hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04429
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SMAD1 | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | UniProt NCBI |
| SMAD5 | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | UniProt NCBI |
| SMURF1 | E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) | UniProt NCBI |
| MARS2 | Methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS) | UniProt NCBI |
| SMURF2 | E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-201451 | 3.2305714914e-09 | 0.8 | SMAD5 SMURF2 SMURF1 SMAD1 | Signaling by BMP |
| KEGG:04350 | 1.65048029426e-07 | 0.8 | SMAD5 SMURF2 SMURF1 SMAD1 | TGF-beta signaling pathway |
| REAC:R-HSA-9006936 | 8.87616987911e-07 | 0.8 | SMAD5 SMURF2 SMURF1 SMAD1 | Signaling by TGF-beta family members |
| WP:WP1425 | 0.00015011307213 | 0.4 | SMAD1 SMURF1 | Bone Morphogenic Protein (BMP) Signalling and Regulation |
| WP:WP3876 | 0.000183446885704 | 0.4 | SMAD5 SMAD1 | BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation |
| GO:0030509 | 0.000339213476695 | 0.8 | SMAD5 SMURF2 SMURF1 SMAD1 | BMP signaling pathway |
| GO:0071772 | 0.000403202499238 | 0.8 | SMAD5 SMURF2 SMURF1 SMAD1 | response to BMP |
| GO:0071773 | 0.000403202499238 | 0.8 | SMAD5 SMURF2 SMURF1 SMAD1 | cellular response to BMP stimulus |
| WP:WP3927 | 0.00045324857597 | 0.4 | SMAD5 SMAD1 | BMP Signaling Pathway in Eyelid Development |
| WP:WP4331 | 0.000632959696686 | 0.4 | SMAD5 SMAD1 | Neovascularisation processes |
| WP:WP2895 | 0.000632959696686 | 0.4 | SMAD5 SMAD1 | Differentiation of white and brown adipocyte |
| GO:0007179 | 0.001292590007 | 0.8 | SMAD5 SMURF2 SMURF1 SMAD1 | transforming growth factor beta receptor signaling pathway |
| WP:WP4249 | 0.00233629086428 | 0.4 | SMURF2 SMURF1 | Hedgehog Signaling Pathway |
| GO:0071560 | 0.00265571901763 | 0.8 | SMAD5 SMURF2 SMURF1 SMAD1 | cellular response to transforming growth factor beta stimulus |
| REAC:R-HSA-2173788 | 0.00282729215335 | 0.4 | SMURF2 SMURF1 | Downregulation of TGF-beta receptor signaling |
| GO:0071559 | 0.00302325172609 | 0.8 | SMAD5 SMURF2 SMURF1 SMAD1 | response to transforming growth factor beta |
| WP:WP560 | 0.00314132080553 | 0.4 | SMAD5 SMAD1 | TGF-beta Receptor Signaling |
| KEGG:04340 | 0.00403884103568 | 0.4 | SMURF2 SMURF1 | Hedgehog signaling pathway |
| REAC:R-HSA-2173789 | 0.00472180750517 | 0.4 | SMURF2 SMURF1 | TGF-beta receptor signaling activates SMADs |
| GO:0007178 | 0.00968108110961 | 0.8 | SMAD5 SMURF2 SMURF1 SMAD1 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| WP:WP3931 | 0.0156686618731 | 0.4 | SMAD5 SMAD1 | ESC Pluripotency Pathways |
| REAC:R-HSA-8941858 | 0.0184727645209 | 0.4 | SMURF2 SMURF1 | Regulation of RUNX3 expression and activity |
| GO:0046332 | 0.022411068229 | 0.6 | SMURF2 SMURF1 SMAD1 | SMAD binding |
| CORUM:2992 | 0.0249780992026 | 0.2 | SMURF2 | Ubiquitin E3 ligase (SMAD7, SMURF2) |
| CORUM:2996 | 0.0249780992026 | 0.2 | SMURF1 | Ubiquitin E3 ligase (SMAD7, SMURF1) |
| WP:WP366 | 0.0250517914711 | 0.4 | SMURF2 SMURF1 | TGF-beta Signaling Pathway |
| REAC:R-HSA-4608870 | 0.0261457156832 | 0.4 | SMURF2 SMURF1 | Asymmetric localization of PCP proteins |
| REAC:R-HSA-170834 | 0.0304761248659 | 0.4 | SMURF2 SMURF1 | Signaling by TGF-beta Receptor Complex |
| MIRNA:hsa-miR-675-3p | 0.0308167272302 | 0.4 | SMAD5 SMAD1 | hsa-miR-675-3p |
| KEGG:04550 | 0.0316942128417 | 0.4 | SMAD5 SMAD1 | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04120 | 0.0353865382697 | 0.4 | SMURF2 SMURF1 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-5632684 | 0.0422076786847 | 0.4 | SMURF2 SMURF1 | Hedgehog 'on' state |
| GO:0030618 | 0.0450641792523 | 0.4 | SMAD5 SMAD1 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
| GO:0030579 | 0.0450641792523 | 0.4 | SMURF2 SMURF1 | ubiquitin-dependent SMAD protein catabolic process |
| CORUM:2958 | 0.0499494897235 | 0.2 | SMAD1 | SMAD1-CBP complex |
| CORUM:1783 | 0.0499494897235 | 0.2 | SMURF1 | Ubiquitin E3 ligase (SMAD7, SMURF1) - TGFBR1 |
| CORUM:2642 | 0.0499494897235 | 0.2 | SMAD1 | SMAD1-P300 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMURF1 | SMURF2 | 1.0 | 0.949 | bioplex (SMURF2) bioplex_WMM |
| SMURF2 | SMAD5 | 0.315 | 0.509 | bioplex (SMURF2) bioplex_WMM |
| SMAD1 | SMURF2 | 0.118 | 0.391 | bioplex (SMURF2) bioplex_WMM |
| SMURF2 | MARS2 | 0.084 | 0.347 | bioplex (SMURF2) bioplex_WMM |
| SMAD1 | SMURF1 | 0.008 | 0.095 | bioplex_WMM WMM_only |
| SMURF1 | SMAD5 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| SMAD1 | SMAD5 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SMURF1 | MARS2 | 0.008 | 0.033 | bioplex_WMM WMM_only |
| SMAD1 | MARS2 | 0.008 | 0.01 | bioplex_WMM WMM_only |
| SMAD5 | MARS2 | 0.007 | 0.016 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04429 has an average edge precision of 0.249 which is ranked 5383 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SMAD1 | HuMAP2_00001 HuMAP2_01252 HuMAP2_02037 HuMAP2_02752 HuMAP2_02905 HuMAP2_04429 |
| SMAD5 | HuMAP2_01252 HuMAP2_01560 HuMAP2_02752 HuMAP2_04429 |
| SMURF1 | HuMAP2_00852 HuMAP2_01252 HuMAP2_02752 HuMAP2_03627 HuMAP2_04429 |
| MARS2 | HuMAP2_01252 HuMAP2_02752 HuMAP2_04429 |
| SMURF2 | HuMAP2_00852 HuMAP2_01252 HuMAP2_02752 HuMAP2_04429 |