hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04453
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| APTX | Aprataxin (EC 3.1.11.7) (EC 3.1.12.2) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | UniProt NCBI |
| GOLGA1 | Golgin subfamily A member 1 (Golgin-97) | UniProt NCBI |
| TDP1 | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | UniProt NCBI |
| PNKP | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] | UniProt NCBI |
| POLB | DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:362 | 4.0241279111e-05 | 0.4 | PNKP POLB | DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex |
| CORUM:5243 | 4.0241279111e-05 | 0.4 | TDP1 PNKP | XRCC1-LIG3-PNK-TDP1 complex |
| REAC:R-HSA-5649702 | 0.000202356855584 | 0.4 | PNKP POLB | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
| HP:0003693 | 0.00247020409708 | 0.6 | TDP1 APTX PNKP | Distal amyotrophy |
| REAC:R-HSA-73933 | 0.00799559968784 | 0.4 | PNKP POLB | Resolution of Abasic Sites (AP sites) |
| HP:0003474 | 0.00938943928499 | 0.6 | TDP1 APTX PNKP | Sensory impairment |
| WP:WP4016 | 0.00992634522128 | 0.4 | TDP1 POLB | DNA IR-damage and cellular response via ATR |
| HP:0001761 | 0.0113465056889 | 0.6 | TDP1 APTX PNKP | Pes cavus |
| HP:0001284 | 0.0122356792032 | 0.6 | TDP1 APTX PNKP | Areflexia |
| GO:0098502 | 0.0135228859698 | 0.4 | PNKP POLB | DNA dephosphorylation |
| REAC:R-HSA-73894 | 0.0143782387474 | 0.6 | TDP1 PNKP POLB | DNA Repair |
| HP:0000640 | 0.0162585949147 | 0.4 | TDP1 APTX | Gaze-evoked nystagmus |
| HP:0003124 | 0.0325153883173 | 0.4 | TDP1 APTX | Hypercholesterolemia |
| HP:0009053 | 0.0398018408038 | 0.4 | TDP1 PNKP | Distal lower limb muscle weakness |
| REAC:R-HSA-73884 | 0.0499209306556 | 0.4 | PNKP POLB | Base Excision Repair |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLB | TDP1 | 0.929 | 0.845 | bioplex (POLB) bioplex_WMM |
| POLB | PNKP | 0.882 | 0.818 | hein_WMM bioplex (POLB) bioplex_WMM |
| TDP1 | GOLGA1 | 0.175 | 0.435 | Guru fraction |
| APTX | POLB | 0.078 | 0.352 | hein_WMM bioplex (POLB) bioplex_WMM |
| APTX | PNKP | 0.012 | 0.146 | hein_WMM bioplex_WMM WMM_only |
| APTX | TDP1 | 0.008 | 0.079 | bioplex_WMM WMM_only |
| PNKP | TDP1 | 0.008 | 0.062 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04453 has an average edge precision of 0.391 which is ranked 3412 out of all 6965 complexes.
Related Complexes