hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04458
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EIF4A1 | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | UniProt NCBI |
| PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta) | UniProt NCBI |
| PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) | UniProt NCBI |
| PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) | UniProt NCBI |
| PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5876 | 9.07524205488e-13 | 0.8 | PPP2CA EIF4A1 PPP2R1B PPP2R1A | PPP2R1A-PPP2R1B-PPP2CA-PPME1-EIF4A1 complex |
| REAC:R-HSA-5467337 | 3.65371807209e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | APC truncation mutants have impaired AXIN binding |
| REAC:R-HSA-5467340 | 3.65371807209e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | AXIN missense mutants destabilize the destruction complex |
| REAC:R-HSA-4839735 | 3.65371807209e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | AXIN mutants destabilize the destruction complex, activating WNT signaling |
| REAC:R-HSA-5467348 | 3.65371807209e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Truncations of AMER1 destabilize the destruction complex |
| REAC:R-HSA-4839748 | 3.65371807209e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | AMER1 mutants destabilize the destruction complex |
| REAC:R-HSA-4839744 | 3.65371807209e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | truncated APC mutants destabilize the destruction complex |
| REAC:R-HSA-5358752 | 4.98207499369e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | T41 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5339716 | 4.98207499369e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Misspliced GSK3beta mutants stabilize beta-catenin |
| REAC:R-HSA-4839743 | 4.98207499369e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex |
| REAC:R-HSA-5358749 | 4.98207499369e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | S37 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358747 | 4.98207499369e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | S33 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358751 | 4.98207499369e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | S45 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-432142 | 8.6857608829e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Platelet sensitization by LDL |
| REAC:R-HSA-389513 | 8.6857608829e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | CTLA4 inhibitory signaling |
| REAC:R-HSA-196299 | 8.6857608829e-10 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Beta-catenin phosphorylation cascade |
| WP:WP500 | 6.65729208537e-09 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Glycogen Synthesis and Degradation |
| REAC:R-HSA-5673000 | 8.66228610405e-09 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | RAF activation |
| REAC:R-HSA-4791275 | 9.99440778064e-09 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Signaling by WNT in cancer |
| REAC:R-HSA-4641262 | 9.99440778064e-09 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| REAC:R-HSA-5675221 | 2.40770685636e-08 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Negative regulation of MAPK pathway |
| REAC:R-HSA-163767 | 9.51308232652e-08 | 0.6 | PPP2CA PPP2R1B PPP2R1A | PP2A-mediated dephosphorylation of key metabolic factors |
| REAC:R-HSA-388841 | 1.15185554341e-07 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Costimulation by the CD28 family |
| KEGG:03015 | 2.69671550532e-07 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | mRNA surveillance pathway |
| WP:WP399 | 3.11497655734e-07 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Wnt Signaling Pathway and Pluripotency |
| REAC:R-HSA-6811558 | 3.14615795114e-07 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-2465910 | 3.26064244298e-07 | 0.6 | PPP2CA PPP2R1B PPP2R1A | MASTL Facilitates Mitotic Progression |
| REAC:R-HSA-199418 | 4.66733827537e-07 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Negative regulation of the PI3K/AKT network |
| GO:0000159 | 4.7240495605e-07 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | protein phosphatase type 2A complex |
| REAC:R-HSA-418346 | 4.92281730711e-07 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Platelet homeostasis |
| KEGG:04114 | 5.96187048479e-07 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Oocyte meiosis |
| REAC:R-HSA-9634600 | 5.97663979449e-07 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism |
| REAC:R-HSA-195253 | 6.36085103797e-07 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Degradation of beta-catenin by the destruction complex |
| KEGG:04071 | 6.42633295556e-07 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Sphingolipid signaling pathway |
| KEGG:04152 | 7.17320277737e-07 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | AMPK signaling pathway |
| REAC:R-HSA-113501 | 7.76884875116e-07 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-202670 | 7.76884875116e-07 | 0.6 | PPP2CA PPP2R1B PPP2R1A | ERKs are inactivated |
| KEGG:04728 | 9.80702381829e-07 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Dopaminergic synapse |
| REAC:R-HSA-141444 | 1.01560921166e-06 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 1.01560921166e-06 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Amplification of signal from the kinetochores |
| KEGG:04261 | 1.27036260649e-06 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Adrenergic signaling in cardiomyocytes |
| REAC:R-HSA-69618 | 1.87424072127e-06 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Mitotic Spindle Checkpoint |
| REAC:R-HSA-2500257 | 2.98128870159e-06 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-113510 | 4.17943282079e-06 | 0.6 | PPP2CA PPP2R1B PPP2R1A | E2F mediated regulation of DNA replication |
| REAC:R-HSA-198753 | 4.17943282079e-06 | 0.6 | PPP2CA PPP2R1B PPP2R1A | ERK/MAPK targets |
| REAC:R-HSA-5663220 | 4.51796469523e-06 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | RHO GTPases Activate Formins |
| REAC:R-HSA-180024 | 4.80586315819e-06 | 0.6 | PPP2CA PPP2R1B PPP2R1A | DARPP-32 events |
| REAC:R-HSA-69273 | 6.24012216224e-06 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Cyclin A/B1/B2 associated events during G2/M transition |
| REAC:R-HSA-198725 | 6.24012216224e-06 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Nuclear Events (kinase and transcription factor activation) |
| CORUM:1543 | 6.70868171695e-06 | 0.4 | PPP2R1A PPP2CA | PPP2CA-PPP2R1A complex |
| GO:1903293 | 1.00139303444e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | phosphatase complex |
| GO:0008287 | 1.00139303444e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | protein serine/threonine phosphatase complex |
| REAC:R-HSA-450282 | 1.21879917622e-05 | 0.6 | PPP2CA PPP2R1B PPP2R1A | MAPK targets/ Nuclear events mediated by MAP kinases |
| WP:WP3932 | 1.55793734085e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| REAC:R-HSA-2467813 | 1.63530875512e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Separation of Sister Chromatids |
| REAC:R-HSA-6804757 | 1.77393158174e-05 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Regulation of TP53 Degradation |
| REAC:R-HSA-6806003 | 1.93500285918e-05 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Regulation of TP53 Expression and Degradation |
| REAC:R-HSA-68877 | 1.9424252029e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 1.9424252029e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 1.98364573523e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Mitotic Metaphase and Anaphase |
| CORUM:6183 | 2.0123342217e-05 | 0.4 | PPP2R1A PPP2CA | PP2A A/C-SG2NA complex |
| CORUM:1544 | 2.0123342217e-05 | 0.4 | PPP2R1A PPP2CA | PPP2CA-PPP2R1A-PPP2R3A complex |
| CORUM:6182 | 2.0123342217e-05 | 0.4 | PPP2R1A PPP2CA | PP2A A/C-striatin complex |
| KEGG:04730 | 2.01601392523e-05 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Long-term depression |
| REAC:R-HSA-5673001 | 2.06804793503e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 2.29081302441e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | MAPK1/MAPK3 signaling |
| WP:WP4172 | 2.46316127093e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | PI3K-Akt Signaling Pathway |
| REAC:R-HSA-9607240 | 2.89852727833e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | FLT3 Signaling |
| REAC:R-HSA-69236 | 3.10929802736e-05 | 0.6 | PPP2CA PPP2R1B PPP2R1A | G1 Phase |
| REAC:R-HSA-69231 | 3.10929802736e-05 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Cyclin D associated events in G1 |
| REAC:R-HSA-1280215 | 3.15061991054e-05 | 1.0 | PPP2R5E PPP2CA EIF4A1 PPP2R1B PPP2R1A | Cytokine Signaling in Immune system |
| REAC:R-HSA-201681 | 3.55482668831e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | TCF dependent signaling in response to WNT |
| REAC:R-HSA-1257604 | 3.75166391725e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | PIP3 activates AKT signaling |
| KEGG:04151 | 3.78166640446e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | PI3K-Akt signaling pathway |
| REAC:R-HSA-449836 | 3.8873456186e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Other interleukin signaling |
| CORUM:7005 | 4.0241279111e-05 | 0.4 | PPP2R1A PPP2CA | PP2A-NR3A complex |
| KEGG:05165 | 4.42454478418e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Human papillomavirus infection |
| REAC:R-HSA-5683057 | 4.54388535997e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | MAPK family signaling cascades |
| KEGG:04350 | 6.53049532948e-05 | 0.6 | PPP2CA PPP2R1B PPP2R1A | TGF-beta signaling pathway |
| REAC:R-HSA-9006925 | 7.01630067925e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Intracellular signaling by second messengers |
| KEGG:05142 | 9.41040777628e-05 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Chagas disease (American trypanosomiasis) |
| REAC:R-HSA-69620 | 9.95589136456e-05 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Cell Cycle Checkpoints |
| REAC:R-HSA-450294 | 0.000107327354708 | 0.6 | PPP2CA PPP2R1B PPP2R1A | MAP kinase activation |
| REAC:R-HSA-70171 | 0.000123638575202 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Glycolysis |
| REAC:R-HSA-195258 | 0.00013381858755 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | RHO GTPase Effectors |
| REAC:R-HSA-195721 | 0.000135560445088 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Signaling by WNT |
| REAC:R-HSA-448424 | 0.000141520021869 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Interleukin-17 signaling |
| REAC:R-HSA-187037 | 0.000167928044622 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-5663202 | 0.000189340345518 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Diseases of signal transduction |
| REAC:R-HSA-975871 | 0.000238892911782 | 0.6 | PPP2CA PPP2R1B PPP2R1A | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168142 | 0.000238892911782 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-70326 | 0.000238892911782 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Glucose metabolism |
| REAC:R-HSA-168176 | 0.000238892911782 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975138 | 0.00025697910325 | 0.6 | PPP2CA PPP2R1B PPP2R1A | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 0.000266353842167 | 0.6 | PPP2CA PPP2R1B PPP2R1A | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 0.000266353842167 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-111885 | 0.000275953181812 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Opioid Signalling |
| REAC:R-HSA-68886 | 0.000296458150454 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | M Phase |
| REAC:R-HSA-168188 | 0.000306125075711 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-168138 | 0.000306125075711 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-166058 | 0.000306125075711 | 0.6 | PPP2CA PPP2R1B PPP2R1A | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168164 | 0.000316649083447 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166520 | 0.000327410819085 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Signaling by NTRKs |
| REAC:R-HSA-168179 | 0.000338412904811 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.000338412904811 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-937061 | 0.000349657961729 | 0.6 | PPP2CA PPP2R1B PPP2R1A | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.000349657961729 | 0.6 | PPP2CA PPP2R1B PPP2R1A | MyD88-independent TLR4 cascade |
| KEGG:05160 | 0.000349924863199 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Hepatitis C |
| REAC:R-HSA-163685 | 0.000397120285508 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Integration of energy metabolism |
| KEGG:04390 | 0.000398445237125 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Hippo signaling pathway |
| KEGG:04530 | 0.000424294655338 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Tight junction |
| REAC:R-HSA-194315 | 0.000501262158212 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Signaling by Rho GTPases |
| REAC:R-HSA-2995410 | 0.000606744453221 | 0.4 | PPP2R1A PPP2CA | Nuclear Envelope Reassembly |
| REAC:R-HSA-2995383 | 0.000606744453221 | 0.4 | PPP2R1A PPP2CA | Initiation of Nuclear Envelope Reformation |
| REAC:R-HSA-166016 | 0.000717394603045 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-69206 | 0.000960389260783 | 0.6 | PPP2CA PPP2R1B PPP2R1A | G1/S Transition |
| REAC:R-HSA-449147 | 0.000989720440926 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Signaling by Interleukins |
| REAC:R-HSA-68875 | 0.00100555265154 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Mitotic Prophase |
| REAC:R-HSA-69278 | 0.00103692271301 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Cell Cycle, Mitotic |
| REAC:R-HSA-168898 | 0.00120028939708 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Toll-like Receptor Cascades |
| REAC:R-HSA-109582 | 0.0012064681881 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Hemostasis |
| REAC:R-HSA-1295596 | 0.00122631290825 | 0.4 | PPP2R1A PPP2CA | Spry regulation of FGF signaling |
| REAC:R-HSA-453279 | 0.00138993331814 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Mitotic G1-G1/S phases |
| REAC:R-HSA-5633007 | 0.00169383519446 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Regulation of TP53 Activity |
| REAC:R-HSA-1640170 | 0.0021256129161 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Cell Cycle |
| REAC:R-HSA-5654732 | 0.00230284247734 | 0.4 | PPP2R1A PPP2CA | Negative regulation of FGFR3 signaling |
| REAC:R-HSA-1280218 | 0.00256626643698 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Adaptive Immune System |
| REAC:R-HSA-69275 | 0.00300215492023 | 0.6 | PPP2CA PPP2R1B PPP2R1A | G2/M Transition |
| REAC:R-HSA-453274 | 0.00309784557874 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Mitotic G2-G2/M phases |
| REAC:R-HSA-5654733 | 0.0031096034254 | 0.4 | PPP2R1A PPP2CA | Negative regulation of FGFR4 signaling |
| REAC:R-HSA-5654726 | 0.0031096034254 | 0.4 | PPP2R1A PPP2CA | Negative regulation of FGFR1 signaling |
| REAC:R-HSA-168256 | 0.00339317023665 | 1.0 | PPP2R5E PPP2CA EIF4A1 PPP2R1B PPP2R1A | Immune System |
| REAC:R-HSA-5654727 | 0.00340529843133 | 0.4 | PPP2R1A PPP2CA | Negative regulation of FGFR2 signaling |
| REAC:R-HSA-5654741 | 0.00508433997358 | 0.4 | PPP2R1A PPP2CA | Signaling by FGFR3 |
| REAC:R-HSA-5654743 | 0.00584945327803 | 0.4 | PPP2R1A PPP2CA | Signaling by FGFR4 |
| REAC:R-HSA-418594 | 0.00775951386318 | 0.6 | PPP2CA PPP2R1B PPP2R1A | G alpha (i) signalling events |
| REAC:R-HSA-71387 | 0.00784859202005 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Metabolism of carbohydrates |
| REAC:R-HSA-5654736 | 0.00846479084427 | 0.4 | PPP2R1A PPP2CA | Signaling by FGFR1 |
| REAC:R-HSA-1643685 | 0.0116415059931 | 0.8 | PPP2CA PPP2R5E PPP2R1B PPP2R1A | Disease |
| REAC:R-HSA-3700989 | 0.0182828935298 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Transcriptional Regulation by TP53 |
| GO:0019888 | 0.0211681462149 | 0.6 | PPP2R5E PPP2R1B PPP2R1A | protein phosphatase regulator activity |
| REAC:R-HSA-5654738 | 0.0221443716613 | 0.4 | PPP2R1A PPP2CA | Signaling by FGFR2 |
| MIRNA:hsa-miR-3138 | 0.0235413326705 | 0.4 | PPP2R1A PPP2R5E | hsa-miR-3138 |
| REAC:R-HSA-9006934 | 0.0291077226575 | 0.6 | PPP2CA PPP2R1B PPP2R1A | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-190236 | 0.0295837500362 | 0.4 | PPP2R1A PPP2CA | Signaling by FGFR |
| GO:0019208 | 0.0358473364726 | 0.6 | PPP2R5E PPP2R1B PPP2R1A | phosphatase regulator activity |
| GO:0004722 | 0.0412952841175 | 0.6 | PPP2CA PPP2R1B PPP2R1A | protein serine/threonine phosphatase activity |
| CORUM:6111 | 0.0499494897235 | 0.2 | PPP2CA | protein phosphatase 2A C-subunit-synapsin complex |
| CORUM:6159 | 0.0499494897235 | 0.2 | PPP2CA | LPP-PPP2CA-PPP2R3A complex |
| CORUM:6180 | 0.0499494897235 | 0.2 | PPP2R1A | PPP2R1A-PPP2R3B complex |
| CORUM:1131 | 0.0499494897235 | 0.2 | PPP2R1A | RFC2-RIalpha complex |
| CORUM:1132 | 0.0499494897235 | 0.2 | PPP2R1A | RFC2-RIalpha complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PPP2R1A | PPP2CA | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt (PPP2R1A) hein (PPP2CA,PPP2R1A) gupta_WMM fraction boldt_WMM |
| PPP2R1B | PPP2R1A | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt Malo fraction boldt_WMM |
| PPP2R1B | PPP2CA | 0.996 | 0.927 | hein_WMM bioplex_WMM Guru boldt hein (PPP2CA) fraction boldt_WMM |
| EIF4A1 | PPP2R1A | 0.987 | 0.902 | youn (EIF4A1) bioplex (EIF4A1) boldt youn_WMM fraction boldt_WMM treiber_WMM |
| PPP2R5E | PPP2R1A | 0.973 | 0.886 | hein_WMM bioplex_WMM Guru boldt (PPP2R1A) hein (PPP2R1A) fraction boldt_WMM |
| EIF4A1 | PPP2R1B | 0.87 | 0.804 | fraction |
| PPP2R5E | PPP2CA | 0.83 | 0.777 | hein_WMM bioplex_WMM Guru boldt hein (PPP2CA) fraction boldt_WMM |
| EIF4A1 | PPP2CA | 0.827 | 0.774 | boldt fraction boldt_WMM |
| PPP2R5E | PPP2R1B | 0.172 | 0.431 | hein_WMM bioplex_WMM Guru fraction |
| EIF4A1 | PPP2R5E | 0.0 | 0.001 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
Images
Click to enlarge
Complex HuMAP2_04458 has an average edge precision of 0.74 which is ranked 1203 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EIF4A1 | HuMAP2_00055 HuMAP2_03421 HuMAP2_04458 HuMAP2_05935 |
| PPP2R1B | HuMAP2_02007 HuMAP2_02325 HuMAP2_02930 HuMAP2_04458 |
| PPP2R1A | HuMAP2_02007 HuMAP2_02325 HuMAP2_04458 HuMAP2_05962 |
| PPP2CA | HuMAP2_02007 HuMAP2_03694 HuMAP2_04458 HuMAP2_05962 |
| PPP2R5E | HuMAP2_01267 HuMAP2_01788 HuMAP2_02007 HuMAP2_02325 HuMAP2_04458 |