hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04472
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MFSD4B | Sodium-dependent glucose transporter 1 (Major facilitator superfamily domain-containing protein 4B) | UniProt NCBI |
| NOCT | Nocturnin (EC 3.1.13.4) (Carbon catabolite repression 4-like protein) (Circadian deadenylase NOC) | UniProt NCBI |
| TUBA3D | Tubulin alpha-3D chain (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | UniProt NCBI |
| TXNDC9 | Thioredoxin domain-containing protein 9 (ATP-binding protein associated with cell differentiation) (Protein 1-4) | UniProt NCBI |
| TUBA3E | Tubulin alpha-3E chain (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | UniProt NCBI |
| CHRM3 | Muscarinic acetylcholine receptor M3 | UniProt NCBI |
| TUBAL3 | Tubulin alpha chain-like 3 | UniProt NCBI |
| TCP11L2 | T-complex protein 11-like protein 2 | UniProt NCBI |
| TUBA1B | Tubulin alpha-1B chain (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-190840 | 2.9044727664e-08 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| REAC:R-HSA-190872 | 3.73331836831e-08 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Transport of connexons to the plasma membrane |
| REAC:R-HSA-389977 | 7.2960444442e-08 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Post-chaperonin tubulin folding pathway |
| REAC:R-HSA-190861 | 1.07889289355e-07 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Gap junction assembly |
| REAC:R-HSA-9619483 | 1.29432338004e-07 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Activation of AMPK downstream of NMDARs |
| REAC:R-HSA-389960 | 1.29432338004e-07 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Formation of tubulin folding intermediates by CCT/TriC |
| REAC:R-HSA-5626467 | 2.49132113888e-07 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | RHO GTPases activate IQGAPs |
| REAC:R-HSA-389958 | 3.8254549972e-07 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| REAC:R-HSA-190828 | 5.63375764035e-07 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Gap junction trafficking |
| REAC:R-HSA-157858 | 6.35898309752e-07 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Gap junction trafficking and regulation |
| REAC:R-HSA-8955332 | 8.0166750771e-07 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Carboxyterminal post-translational modifications of tubulin |
| REAC:R-HSA-9609736 | 8.95740282778e-07 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Assembly and cell surface presentation of NMDA receptors |
| WP:WP2272 | 9.838220698e-07 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Pathogenic Escherichia coli infection |
| REAC:R-HSA-437239 | 1.80464191314e-06 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Recycling pathway of L1 |
| WP:WP2359 | 2.60925915779e-06 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Parkin-Ubiquitin Proteasomal System pathway |
| REAC:R-HSA-6811436 | 2.78566407265e-06 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 3.27287421627e-06 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| REAC:R-HSA-983189 | 4.7689670212e-06 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Kinesins |
| KEGG:04540 | 5.94128824877e-06 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Gap junction |
| REAC:R-HSA-1445148 | 9.80300314461e-06 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-438064 | 1.30841265756e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Post NMDA receptor activation events |
| REAC:R-HSA-8852276 | 1.5410306565e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | The role of GTSE1 in G2/M progression after G2 checkpoint |
| REAC:R-HSA-442755 | 2.31260502751e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Activation of NMDA receptors and postsynaptic events |
| KEGG:04210 | 2.95131472279e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Apoptosis |
| REAC:R-HSA-390466 | 3.05757392315e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Chaperonin-mediated protein folding |
| REAC:R-HSA-380320 | 3.05757392315e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-391251 | 3.96867271734e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Protein folding |
| REAC:R-HSA-6811434 | 3.96867271734e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | COPI-dependent Golgi-to-ER retrograde traffic |
| KEGG:04145 | 4.01892231868e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Phagosome |
| REAC:R-HSA-6807878 | 4.13825173994e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | COPI-mediated anterograde transport |
| KEGG:04530 | 5.35089478374e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Tight junction |
| REAC:R-HSA-373760 | 7.12602818427e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | L1CAM interactions |
| REAC:R-HSA-2132295 | 8.50813693396e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | MHC class II antigen presentation |
| REAC:R-HSA-2500257 | 9.75039727383e-05 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Resolution of Sister Chromatid Cohesion |
| KEGG:05130 | 0.000118681936928 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Pathogenic Escherichia coli infection |
| REAC:R-HSA-8856688 | 0.000134462084508 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Golgi-to-ER retrograde transport |
| REAC:R-HSA-5663220 | 0.000147346986949 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | RHO GTPases Activate Formins |
| REAC:R-HSA-199977 | 0.000202588963047 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | ER to Golgi Anterograde Transport |
| REAC:R-HSA-983231 | 0.000301110875789 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-948021 | 0.000384143353592 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-112314 | 0.000441498518518 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-2467813 | 0.000527594387281 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Separation of Sister Chromatids |
| REAC:R-HSA-69275 | 0.000612657843157 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | G2/M Transition |
| REAC:R-HSA-5617833 | 0.000625593313678 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Cilium Assembly |
| REAC:R-HSA-68877 | 0.000625593313678 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.000625593313678 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.000638730732164 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-453274 | 0.000638730732164 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Mitotic G2-G2/M phases |
| REAC:R-HSA-6811442 | 0.000707518898089 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-112315 | 0.0012422557909 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Transmission across Chemical Synapses |
| REAC:R-HSA-1852241 | 0.00280897927317 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Organelle biogenesis and maintenance |
| REAC:R-HSA-446203 | 0.00305492506614 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Asparagine N-linked glycosylation |
| REAC:R-HSA-195258 | 0.0042008138714 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | RHO GTPase Effectors |
| REAC:R-HSA-112316 | 0.00618765661226 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Neuronal System |
| REAC:R-HSA-68886 | 0.00916939399456 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | M Phase |
| REAC:R-HSA-2262752 | 0.012368114635 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Cellular responses to stress |
| REAC:R-HSA-194315 | 0.0153253364364 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Signaling by Rho GTPases |
| REAC:R-HSA-8953897 | 0.02506295601 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Cellular responses to external stimuli |
| REAC:R-HSA-422475 | 0.0304159320284 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Axon guidance |
| REAC:R-HSA-69278 | 0.0311101412477 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Cell Cycle, Mitotic |
| REAC:R-HSA-109582 | 0.0360381630385 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Hemostasis |
| REAC:R-HSA-199991 | 0.0491816508588 | 0.444444444444 | TUBAL3 TUBA3E TUBA3D TUBA1B | Membrane Trafficking |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TUBA3D | TCP11L2 | 0.163 | 0.42 | bioplex (TUBA3D) bioplex_WMM |
| MFSD4B | TUBA3D | 0.154 | 0.414 | bioplex (TUBA3D) bioplex_WMM |
| TUBA1B | TCP11L2 | 0.136 | 0.406 | hein_WMM bioplex (TUBA1B) bioplex_WMM |
| TUBAL3 | TXNDC9 | 0.04 | 0.268 | bioplex (TUBAL3,TXNDC9) bioplex_WMM youn_WMM gupta_WMM |
| TUBA1B | TXNDC9 | 0.04 | 0.266 | hein_WMM bioplex (TUBA1B) bioplex_WMM youn_WMM gupta_WMM boldt_WMM |
| TUBA3D | CHRM3 | 0.038 | 0.264 | bioplex (CHRM3) bioplex_WMM |
| TUBA3D | TXNDC9 | 0.035 | 0.26 | bioplex (TUBA3D) bioplex_WMM |
| CHRM3 | NOCT | 0.025 | 0.211 | bioplex (CHRM3) bioplex_WMM |
| TUBA3E | TUBA1B | 0.024 | 0.216 | hein_WMM hein (TUBA3E) gupta_WMM |
| TCP11L2 | TUBAL3 | 0.014 | 0.143 | bioplex (TCP11L2) bioplex_WMM |
| TCP11L2 | TXNDC9 | 0.011 | 0.133 | hein_WMM bioplex_WMM WMM_only |
| MFSD4B | TCP11L2 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| TUBA1B | TUBAL3 | 0.007 | 0.005 | bioplex (TUBA1B) bioplex_WMM youn_WMM gupta_WMM |
| MFSD4B | TUBAL3 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| TUBA1B | MFSD4B | 0.007 | 0.006 | bioplex_WMM boldt boldt_WMM |
| MFSD4B | TXNDC9 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| TUBA3E | TXNDC9 | 0.007 | 0.004 | hein_WMM bioplex (TUBA3E) bioplex_WMM hein (TUBA3E) |
| TUBA3D | NOCT | 0.006 | 0.003 | bioplex_WMM WMM_only |
| TUBA1B | TUBA3D | 0.006 | 0.006 | bioplex_WMM boldt |
| TUBA1B | CHRM3 | 0.006 | 0.004 | bioplex (CHRM3) bioplex_WMM |
| TUBA1B | NOCT | 0.006 | 0.007 | bioplex (NOCT) bioplex_WMM boldt_WMM |
| TUBA3D | TUBAL3 | 0.005 | 0.009 | bioplex (TUBA3D) bioplex_WMM |
| TUBA3E | TUBAL3 | 0.005 | 0.009 | bioplex (TUBA3E) gupta_WMM |
| TUBAL3 | NOCT | 0.005 | 0.003 | bioplex (NOCT) bioplex_WMM |
| CHRM3 | TUBAL3 | 0.005 | 0.007 | bioplex (CHRM3) bioplex_WMM |
| TUBA3E | TCP11L2 | 0.0 | 0.001 | bioplex (TUBA3E) bioplex_WMM |
Images
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Complex HuMAP2_04472 has an average edge precision of 0.118 which is ranked 6879 out of all 6965 complexes.
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