hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04482
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NPAS1 | Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5) | UniProt NCBI |
| HIF1A | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | UniProt NCBI |
| ARNT | Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5382 | 3.35600554376e-06 | 0.666666666667 | ARNT HIF1A | ARNT-HIF1A complex |
| WP:WP1539 | 0.000242449141731 | 0.666666666667 | ARNT HIF1A | Angiogenesis |
| REAC:R-HSA-1234158 | 0.000301184970683 | 0.666666666667 | ARNT HIF1A | Regulation of gene expression by Hypoxia-inducible Factor |
| WP:WP4241 | 0.000416728443271 | 0.666666666667 | ARNT HIF1A | Type 2 papillary renal cell carcinoma |
| WP:WP3614 | 0.000505754093136 | 0.666666666667 | ARNT HIF1A | Photodynamic therapy-induced HIF-1 survival signaling |
| KEGG:05211 | 0.00087223886567 | 0.666666666667 | ARNT HIF1A | Renal cell carcinoma |
| KEGG:04066 | 0.00220707183162 | 0.666666666667 | ARNT HIF1A | HIF-1 signaling pathway |
| WP:WP4018 | 0.00302048413579 | 0.666666666667 | ARNT HIF1A | Pathways in clear cell renal cell carcinoma |
| REAC:R-HSA-1234174 | 0.0180259784934 | 0.666666666667 | ARNT HIF1A | Cellular response to hypoxia |
| GO:0043619 | 0.0283955176165 | 0.666666666667 | ARNT HIF1A | regulation of transcription from RNA polymerase II promoter in response to oxidative stress |
| GO:0046886 | 0.0283955176165 | 0.666666666667 | ARNT HIF1A | positive regulation of hormone biosynthetic process |
| WP:WP3672 | 0.0357037760272 | 0.333333333333 | HIF1A | LncRNA-mediated mechanisms of therapeutic resistance |
| GO:0032352 | 0.0378589948753 | 0.666666666667 | ARNT HIF1A | positive regulation of hormone metabolic process |
| MIRNA:hsa-miR-497-3p | 0.0384874919534 | 0.666666666667 | NPAS1 HIF1A | hsa-miR-497-3p |
| MIRNA:hsa-miR-4418 | 0.0420793313921 | 0.666666666667 | NPAS1 HIF1A | hsa-miR-4418 |
| MIRNA:hsa-miR-509-5p | 0.0439350747985 | 0.666666666667 | NPAS1 HIF1A | hsa-miR-509-5p |
| MIRNA:hsa-miR-509-3-5p | 0.0448778976792 | 0.666666666667 | NPAS1 HIF1A | hsa-miR-509-3-5p |
| KEGG:05200 | 0.0473113658041 | 0.666666666667 | ARNT HIF1A | Pathways in cancer |
| CORUM:4043 | 0.0499776345577 | 0.333333333333 | ARNT | NEMO-HIF2(alpha)-ARNT complex |
| CORUM:7273 | 0.0499776345577 | 0.333333333333 | HIF1A | ARNTL-HIF1A complex |
| CORUM:2152 | 0.0499776345577 | 0.333333333333 | ARNT | ARNT-HLF complex |
| WP:WP3593 | 0.0499785733994 | 0.333333333333 | HIF1A | MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HIF1A | ARNT | 0.896 | 0.821 | hein_WMM bioplex (HIF1A) bioplex_WMM youn_WMM hein (HIF1A) |
| ARNT | NPAS1 | 0.712 | 0.728 | bioplex (NPAS1) bioplex_WMM |
Images
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Complex HuMAP2_04482 has an average edge precision of 0.774 which is ranked 1018 out of all 6965 complexes.
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