hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04487
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | UniProt NCBI |
| KSR1 | Kinase suppressor of Ras 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5921 | 5.02777038712e-06 | 1.0 | KSR1 MAP2K1 | KSR1-BRAF-MEK complex |
| CORUM:5920 | 5.02777038712e-06 | 1.0 | KSR1 MAP2K1 | KSR1-RAF1-MEK complex |
| CORUM:5877 | 1.67592346237e-05 | 1.0 | KSR1 MAP2K1 | MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex |
| REAC:R-HSA-5673000 | 0.000680424925724 | 1.0 | KSR1 MAP2K1 | RAF activation |
| REAC:R-HSA-6802948 | 0.0010558317813 | 1.0 | KSR1 MAP2K1 | Signaling by high-kinase activity BRAF mutants |
| REAC:R-HSA-5675221 | 0.00111616502594 | 1.0 | KSR1 MAP2K1 | Negative regulation of MAPK pathway |
| REAC:R-HSA-5674135 | 0.00130722030065 | 1.0 | KSR1 MAP2K1 | MAP2K and MAPK activation |
| REAC:R-HSA-6802946 | 0.00158542359541 | 1.0 | KSR1 MAP2K1 | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-6802955 | 0.00158542359541 | 1.0 | KSR1 MAP2K1 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| KEGG:04014 | 0.00245633105307 | 1.0 | KSR1 MAP2K1 | Ras signaling pathway |
| REAC:R-HSA-6802949 | 0.00258092213206 | 1.0 | KSR1 MAP2K1 | Signaling by RAS mutants |
| REAC:R-HSA-6802952 | 0.00327307852202 | 1.0 | KSR1 MAP2K1 | Signaling by BRAF and RAF fusions |
| WP:WP2380 | 0.00342029662517 | 1.0 | KSR1 MAP2K1 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| WP:WP4223 | 0.00444675819405 | 1.0 | KSR1 MAP2K1 | Ras Signaling |
| REAC:R-HSA-6802957 | 0.00503279815751 | 1.0 | KSR1 MAP2K1 | Oncogenic MAPK signaling |
| CORUM:5918 | 0.0249595281251 | 0.5 | KSR1 | KSR1 homo-oligomer complex |
| REAC:R-HSA-5673001 | 0.0313749631391 | 1.0 | KSR1 MAP2K1 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.0330173681322 | 1.0 | KSR1 MAP2K1 | MAPK1/MAPK3 signaling |
| REAC:R-HSA-9607240 | 0.0371300843089 | 1.0 | KSR1 MAP2K1 | FLT3 Signaling |
| REAC:R-HSA-449836 | 0.0429891127334 | 1.0 | KSR1 MAP2K1 | Other interleukin signaling |
| REAC:R-HSA-5683057 | 0.0464733576116 | 1.0 | KSR1 MAP2K1 | MAPK family signaling cascades |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAP2K1 | KSR1 | 0.02 | 0.188 | hein_WMM hein (MAP2K1) |
Images
Click to enlarge
Complex HuMAP2_04487 has an average edge precision of 0.188 which is ranked 6328 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAP2K1 | HuMAP2_01070 HuMAP2_03036 HuMAP2_04487 HuMAP2_04871 |
| KSR1 | HuMAP2_01070 HuMAP2_04487 |