hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04491
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| APP | Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31] | UniProt NCBI |
| FRMD6 | FERM domain-containing protein 6 (Willin) | UniProt NCBI |
| CES2 | Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56) | UniProt NCBI |
| ZNF555 | Zinc finger protein 555 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2711 | 0.0249595281251 | 0.25 | APP | Amyloid beta protein homo-oligomer complex |
| CORUM:6056 | 0.0249595281251 | 0.25 | APP | APP-TNFRSF21 complex |
| WP:WP2645 | 0.025016499339 | 0.25 | CES2 | Heroin metabolism |
| WP:WP2826 | 0.025016499339 | 0.25 | CES2 | Cocaine metabolism |
| CORUM:3092 | 0.0499140284799 | 0.25 | APP | APP-TOM40 complex |
| CORUM:3093 | 0.0499140284799 | 0.25 | APP | APP-TIM23 complex |
| CORUM:7529 | 0.0499140284799 | 0.25 | APP | APP-Abeta42-VDAC1 complex |
| CORUM:7574 | 0.0499140284799 | 0.25 | APP | APP-PSEN1 complex |
| CORUM:7575 | 0.0499140284799 | 0.25 | APP | APP-PSEN2 complex |
| CORUM:7579 | 0.0499140284799 | 0.25 | APP | APP(AICD)-MED12 complex |
| CORUM:7587 | 0.0499140284799 | 0.25 | APP | APP(AICD)-FOXO3 complex |
| CORUM:7588 | 0.0499140284799 | 0.25 | APP | APP(AICD)-FOXO1 complex |
| CORUM:7589 | 0.0499140284799 | 0.25 | APP | APP(AICD)-FOXO4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| APP | CES2 | 0.839 | 0.783 | bioplex (APP) bioplex_WMM |
| FRMD6 | APP | 0.027 | 0.222 | bioplex (APP) bioplex_WMM |
| APP | ZNF555 | 0.023 | 0.21 | bioplex (APP) bioplex_WMM |
| CES2 | ZNF555 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| FRMD6 | CES2 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| FRMD6 | ZNF555 | 0.008 | 0.046 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04491 has an average edge precision of 0.239 which is ranked 5537 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| APP | HuMAP2_01871 HuMAP2_03510 HuMAP2_03599 HuMAP2_04491 |
| FRMD6 | HuMAP2_00008 HuMAP2_01276 HuMAP2_02376 HuMAP2_02503 HuMAP2_04109 HuMAP2_04491 |
| CES2 | HuMAP2_01871 HuMAP2_03599 HuMAP2_04491 |
| ZNF555 | HuMAP2_03599 HuMAP2_04491 |