hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04500
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| THOC5 | THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90) | UniProt NCBI |
| THOC6 | THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58) | UniProt NCBI |
| THOC7 | THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30) | UniProt NCBI |
| THOC1 | THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84) | UniProt NCBI |
| THOC2 | THO complex subunit 2 (Tho2) (hTREX120) | UniProt NCBI |
| THOC3 | THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6160 | 4.09578169876e-21 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | hTREX84 complex |
| CORUM:770 | 2.86704718913e-20 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | TREX complex |
| GO:0000347 | 3.3012000492e-18 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | THO complex |
| GO:0000445 | 3.3012000492e-18 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | THO complex part of transcription export complex |
| GO:0051836 | 2.31084003444e-17 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | translocation of molecules into other organism involved in symbiotic interaction |
| GO:0046784 | 2.31084003444e-17 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | viral mRNA export from host cell nucleus |
| GO:0044417 | 2.31084003444e-17 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | translocation of molecules into host |
| CORUM:774 | 6.09820937128e-17 | 0.833333333333 | THOC2 THOC6 THOC1 THOC7 THOC5 | THO complex |
| GO:0000346 | 5.66485928443e-15 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | transcription export complex |
| REAC:R-HSA-72187 | 2.79543076619e-13 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 7.35415597601e-13 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | RNA Polymerase II Transcription Termination |
| REAC:R-HSA-159236 | 1.1846799495e-12 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-72202 | 2.56620983017e-12 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | Transport of Mature Transcript to Cytoplasm |
| CORUM:351 | 3.84254950184e-11 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | Spliceosome |
| KEGG:03013 | 4.93136104216e-11 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | RNA transport |
| GO:1902579 | 3.95739516464e-10 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | multi-organism localization |
| GO:0044766 | 3.95739516464e-10 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | multi-organism transport |
| REAC:R-HSA-72203 | 2.37414340834e-09 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0031124 | 2.51632482928e-09 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | mRNA 3'-end processing |
| GO:0006406 | 5.96607933626e-09 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | mRNA export from nucleus |
| GO:0071427 | 5.96607933626e-09 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | mRNA-containing ribonucleoprotein complex export from nucleus |
| GO:0051028 | 7.89781695835e-09 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | mRNA transport |
| GO:0000784 | 1.08779320075e-08 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | nuclear chromosome, telomeric region |
| GO:0051701 | 1.26875796745e-08 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | interaction with host |
| GO:0071426 | 1.33438337956e-08 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | ribonucleoprotein complex export from nucleus |
| GO:0071166 | 1.40281329646e-08 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | ribonucleoprotein complex localization |
| GO:0006405 | 2.06313639552e-08 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | RNA export from nucleus |
| GO:0031123 | 2.36959472986e-08 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | RNA 3'-end processing |
| GO:0000781 | 2.96436225998e-08 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | chromosome, telomeric region |
| GO:0050657 | 4.71972594968e-08 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | nucleic acid transport |
| GO:0050658 | 4.71972594968e-08 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | RNA transport |
| GO:0051236 | 5.32586992553e-08 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | establishment of RNA localization |
| GO:0006611 | 6.47984375402e-08 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | protein export from nucleus |
| GO:0051168 | 1.01226158913e-07 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | nuclear export |
| GO:0015931 | 1.12604284305e-07 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | nucleobase-containing compound transport |
| GO:0006403 | 1.75001952721e-07 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | RNA localization |
| GO:0031503 | 6.18976995491e-07 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | protein-containing complex localization |
| REAC:R-HSA-8953854 | 1.12851005092e-06 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | Metabolism of RNA |
| GO:0006913 | 1.60573024546e-06 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | nucleocytoplasmic transport |
| GO:0051169 | 1.71772000482e-06 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | nuclear transport |
| GO:0098687 | 1.79593670521e-06 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | chromosomal region |
| GO:0006397 | 1.75466405335e-05 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | mRNA processing |
| REAC:R-HSA-73857 | 3.48623271686e-05 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | RNA Polymerase II Transcription |
| GO:0044403 | 5.36661004937e-05 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | symbiotic process |
| REAC:R-HSA-74160 | 6.720667947e-05 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | Gene expression (Transcription) |
| GO:0044419 | 7.47001039133e-05 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | interspecies interaction between organisms |
| GO:0016071 | 0.000589815677807 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | mRNA metabolic process |
| KEGG:03040 | 0.000590221771159 | 0.5 | THOC3 THOC1 THOC2 | Spliceosome |
| GO:0006396 | 0.000951885417861 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | RNA processing |
| GO:0006886 | 0.00271725025514 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | intracellular protein transport |
| GO:0044454 | 0.00288133296855 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | nuclear chromosome part |
| GO:0000228 | 0.0033810209942 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | nuclear chromosome |
| CORUM:0000000 | 0.0090785708022 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | CORUM root |
| GO:0044427 | 0.0151552637177 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | chromosomal part |
| GO:0005694 | 0.0188325821521 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | chromosome |
| GO:0015031 | 0.0243090283682 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | protein transport |
| GO:0015833 | 0.0264846072029 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | peptide transport |
| GO:0042886 | 0.0285664366252 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | amide transport |
| GO:0046907 | 0.038148924612 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | intracellular transport |
| GO:0045184 | 0.0384716494008 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | establishment of protein localization |
| GO:2000002 | 0.0405595771497 | 0.333333333333 | THOC5 THOC1 | negative regulation of DNA damage checkpoint |
| GO:0051704 | 0.0490703136228 | 1.0 | THOC6 THOC7 THOC5 THOC2 THOC3 THOC1 | multi-organism process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| THOC5 | THOC1 | 1.0 | 0.949 | hein_WMM youn (THOC1) bioplex (THOC1) bioplex_WMM youn_WMM hein (THOC1,THOC5) Malo fraction |
| THOC1 | THOC6 | 1.0 | 0.949 | hein_WMM youn (THOC1) bioplex (THOC1) bioplex_WMM youn_WMM hein (THOC1) Malo fraction |
| THOC7 | THOC1 | 1.0 | 0.949 | hein_WMM youn (THOC1) bioplex (THOC1) bioplex_WMM hein (THOC1,THOC7) Malo fraction |
| THOC2 | THOC1 | 1.0 | 0.949 | hein_WMM youn (THOC1) bioplex (THOC1) bioplex_WMM youn_WMM hein (THOC1,THOC2) Malo gupta_WMM fraction |
| THOC3 | THOC1 | 1.0 | 0.949 | hein_WMM youn (THOC1) bioplex (THOC1,THOC3) bioplex_WMM youn_WMM hein (THOC1) Malo gupta_WMM fraction |
| THOC7 | THOC5 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (THOC5,THOC7) Malo fraction |
| THOC2 | THOC7 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (THOC2,THOC7) Malo gupta_WMM fraction |
| THOC3 | THOC2 | 0.999 | 0.949 | hein_WMM bioplex (THOC3) bioplex_WMM youn_WMM hein (THOC2) Malo gupta_WMM fraction |
| THOC3 | THOC7 | 0.999 | 0.949 | hein_WMM bioplex (THOC3) bioplex_WMM youn_WMM hein (THOC7) Malo fraction |
| THOC3 | THOC5 | 0.999 | 0.948 | hein_WMM bioplex (THOC3) bioplex_WMM youn_WMM hein (THOC5) Malo fraction |
| THOC7 | THOC6 | 0.999 | 0.948 | hein_WMM bioplex_WMM youn_WMM hein (THOC7) Malo fraction |
| THOC5 | THOC6 | 0.998 | 0.939 | hein_WMM bioplex_WMM Guru youn_WMM hein (THOC5) Malo fraction |
| THOC2 | THOC6 | 0.993 | 0.918 | hein_WMM bioplex_WMM youn_WMM hein (THOC2) Malo fraction |
| THOC2 | THOC5 | 0.988 | 0.902 | hein_WMM bioplex_WMM youn_WMM hein (THOC2,THOC5) Malo fraction |
| THOC3 | THOC6 | 0.866 | 0.801 | hein_WMM bioplex (THOC3) bioplex_WMM youn_WMM Malo fraction |
Images
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Complex HuMAP2_04500 has an average edge precision of 0.933 which is ranked 424 out of all 6965 complexes.
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