hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04513
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| POLR2F | DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (DNA-directed RNA polymerase II subunit F) (DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide) (RPABC14.4) (RPB14.4) (RPB6 homolog) (RPC15) | UniProt NCBI |
| POLR2K | DNA-directed RNA polymerases I, II, and III subunit RPABC4 (RNA polymerases I, II, and III subunit ABC4) (ABC10-alpha) (DNA-directed RNA polymerase II subunit K) (RNA polymerase II 7.0 kDa subunit) (RPB7.0) (RPB10alpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03020 | 6.3465431699e-05 | 1.0 | POLR2K POLR2F | RNA polymerase |
| CORUM:104 | 0.000110610948517 | 1.0 | POLR2K POLR2F | RNA polymerase II core complex |
| CORUM:2686 | 0.000130722030065 | 1.0 | POLR2K POLR2F | BRCA1-core RNA polymerase II complex |
| CORUM:2685 | 0.000227925590883 | 1.0 | POLR2K POLR2F | RNA polymerase II (RNAPII) |
| KEGG:04623 | 0.000241168640456 | 1.0 | POLR2K POLR2F | Cytosolic DNA-sensing pathway |
| REAC:R-HSA-73780 | 0.000256416289743 | 1.0 | POLR2K POLR2F | RNA Polymerase III Chain Elongation |
| REAC:R-HSA-8851708 | 0.000286582912066 | 1.0 | POLR2K POLR2F | Signaling by FGFR2 IIIa TM |
| WP:WP405 | 0.000305516692009 | 1.0 | POLR2K POLR2F | Eukaryotic Transcription Initiation |
| REAC:R-HSA-73980 | 0.000424008635981 | 1.0 | POLR2K POLR2F | RNA Polymerase III Transcription Termination |
| REAC:R-HSA-167242 | 0.000424008635981 | 1.0 | POLR2K POLR2F | Abortive elongation of HIV-1 transcript in the absence of Tat |
| REAC:R-HSA-203927 | 0.000462554875615 | 1.0 | POLR2K POLR2F | MicroRNA (miRNA) biogenesis |
| CORUM:103 | 0.000462554875615 | 1.0 | POLR2K POLR2F | RNA polymerase II holoenzyme complex |
| REAC:R-HSA-1839126 | 0.000502777038712 | 1.0 | POLR2K POLR2F | FGFR2 mutant receptor activation |
| REAC:R-HSA-6803529 | 0.000544675125272 | 1.0 | POLR2K POLR2F | FGFR2 alternative splicing |
| CORUM:2825 | 0.000544675125272 | 1.0 | POLR2K POLR2F | BRCA1-RNA polymerase II complex |
| REAC:R-HSA-76066 | 0.000588249135293 | 1.0 | POLR2K POLR2F | RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| REAC:R-HSA-77075 | 0.000588249135293 | 1.0 | POLR2K POLR2F | RNA Pol II CTD phosphorylation and interaction with CE |
| REAC:R-HSA-167160 | 0.000588249135293 | 1.0 | POLR2K POLR2F | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| REAC:R-HSA-76071 | 0.000633499068778 | 1.0 | POLR2K POLR2F | RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| REAC:R-HSA-76061 | 0.000633499068778 | 1.0 | POLR2K POLR2F | RNA Polymerase III Transcription Initiation From Type 1 Promoter |
| REAC:R-HSA-72086 | 0.000680424925724 | 1.0 | POLR2K POLR2F | mRNA Capping |
| REAC:R-HSA-5601884 | 0.000680424925724 | 1.0 | POLR2K POLR2F | PIWI-interacting RNA (piRNA) biogenesis |
| REAC:R-HSA-73863 | 0.000779304410004 | 1.0 | POLR2K POLR2F | RNA Polymerase I Transcription Termination |
| REAC:R-HSA-167238 | 0.000831258037338 | 1.0 | POLR2K POLR2F | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-167243 | 0.000831258037338 | 1.0 | POLR2K POLR2F | Tat-mediated HIV elongation arrest and recovery |
| WP:WP4655 | 0.000848740273654 | 1.0 | POLR2K POLR2F | Cytosolic DNA-sensing pathway |
| REAC:R-HSA-113418 | 0.000884887588134 | 1.0 | POLR2K POLR2F | Formation of the Early Elongation Complex |
| REAC:R-HSA-167158 | 0.000884887588134 | 1.0 | POLR2K POLR2F | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-167287 | 0.000940193062392 | 1.0 | POLR2K POLR2F | HIV elongation arrest and recovery |
| REAC:R-HSA-5655253 | 0.000940193062392 | 1.0 | POLR2K POLR2F | Signaling by FGFR2 in disease |
| REAC:R-HSA-167290 | 0.000940193062392 | 1.0 | POLR2K POLR2F | Pausing and recovery of HIV elongation |
| REAC:R-HSA-76046 | 0.0010558317813 | 1.0 | POLR2K POLR2F | RNA Polymerase III Transcription Initiation |
| REAC:R-HSA-168325 | 0.00130722030065 | 1.0 | POLR2K POLR2F | Viral Messenger RNA Synthesis |
| REAC:R-HSA-749476 | 0.00137425723915 | 1.0 | POLR2K POLR2F | RNA Polymerase III Abortive And Retractive Initiation |
| REAC:R-HSA-74158 | 0.00137425723915 | 1.0 | POLR2K POLR2F | RNA Polymerase III Transcription |
| REAC:R-HSA-167169 | 0.00158542359541 | 1.0 | POLR2K POLR2F | HIV Transcription Elongation |
| REAC:R-HSA-167246 | 0.00158542359541 | 1.0 | POLR2K POLR2F | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167200 | 0.00158542359541 | 1.0 | POLR2K POLR2F | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167152 | 0.00173458078356 | 1.0 | POLR2K POLR2F | Formation of HIV elongation complex in the absence of HIV Tat |
| REAC:R-HSA-73776 | 0.00181167326283 | 1.0 | POLR2K POLR2F | RNA Polymerase II Promoter Escape |
| REAC:R-HSA-76042 | 0.00181167326283 | 1.0 | POLR2K POLR2F | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| REAC:R-HSA-73779 | 0.00181167326283 | 1.0 | POLR2K POLR2F | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| REAC:R-HSA-167162 | 0.00181167326283 | 1.0 | POLR2K POLR2F | RNA Polymerase II HIV Promoter Escape |
| REAC:R-HSA-73762 | 0.00181167326283 | 1.0 | POLR2K POLR2F | RNA Polymerase I Transcription Initiation |
| REAC:R-HSA-75953 | 0.00181167326283 | 1.0 | POLR2K POLR2F | RNA Polymerase II Transcription Initiation |
| REAC:R-HSA-167161 | 0.00181167326283 | 1.0 | POLR2K POLR2F | HIV Transcription Initiation |
| REAC:R-HSA-72165 | 0.00222227451111 | 1.0 | POLR2K POLR2F | mRNA Splicing - Minor Pathway |
| KEGG:05016 | 0.00224682217969 | 1.0 | POLR2K POLR2F | Huntington disease |
| REAC:R-HSA-1226099 | 0.00230942253115 | 1.0 | POLR2K POLR2F | Signaling by FGFR in disease |
| REAC:R-HSA-6781823 | 0.00230942253115 | 1.0 | POLR2K POLR2F | Formation of TC-NER Pre-Incision Complex |
| REAC:R-HSA-5654738 | 0.00277030148331 | 1.0 | POLR2K POLR2F | Signaling by FGFR2 |
| REAC:R-HSA-75955 | 0.00286750504412 | 1.0 | POLR2K POLR2F | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 0.00286750504412 | 1.0 | POLR2K POLR2F | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-6796648 | 0.00316917126735 | 1.0 | POLR2K POLR2F | TP53 Regulates Transcription of DNA Repair Genes |
| REAC:R-HSA-1834949 | 0.00327307852202 | 1.0 | POLR2K POLR2F | Cytosolic sensors of pathogen-associated DNA |
| REAC:R-HSA-6782210 | 0.00337866170015 | 1.0 | POLR2K POLR2F | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 0.00348592080174 | 1.0 | POLR2K POLR2F | Dual incision in TC-NER |
| REAC:R-HSA-190236 | 0.00370546677531 | 1.0 | POLR2K POLR2F | Signaling by FGFR |
| REAC:R-HSA-167172 | 0.004164669804 | 1.0 | POLR2K POLR2F | Transcription of the HIV genome |
| REAC:R-HSA-6807505 | 0.00452666927187 | 1.0 | POLR2K POLR2F | RNA polymerase II transcribes snRNA genes |
| REAC:R-HSA-6781827 | 0.00503279815751 | 1.0 | POLR2K POLR2F | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-674695 | 0.00556574181855 | 1.0 | POLR2K POLR2F | RNA Polymerase II Pre-transcription Events |
| REAC:R-HSA-5250924 | 0.00656291627866 | 1.0 | POLR2K POLR2F | B-WICH complex positively regulates rRNA expression |
| REAC:R-HSA-73772 | 0.00671207346681 | 1.0 | POLR2K POLR2F | RNA Polymerase I Promoter Escape |
| REAC:R-HSA-5578749 | 0.00863268175469 | 1.0 | POLR2K POLR2F | Transcriptional regulation by small RNAs |
| REAC:R-HSA-5250913 | 0.00897624606448 | 1.0 | POLR2K POLR2F | Positive epigenetic regulation of rRNA expression |
| REAC:R-HSA-427413 | 0.00915054210457 | 1.0 | POLR2K POLR2F | NoRC negatively regulates rRNA expression |
| REAC:R-HSA-5250941 | 0.0096834857656 | 1.0 | POLR2K POLR2F | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73854 | 0.00986448549954 | 1.0 | POLR2K POLR2F | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-5696398 | 0.0100471611569 | 1.0 | POLR2K POLR2F | Nucleotide Excision Repair |
| REAC:R-HSA-73864 | 0.0100471611569 | 1.0 | POLR2K POLR2F | RNA Polymerase I Transcription |
| REAC:R-HSA-5619507 | 0.0109856782959 | 1.0 | POLR2K POLR2F | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 0.0109856782959 | 1.0 | POLR2K POLR2F | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| REAC:R-HSA-168273 | 0.014052618232 | 1.0 | POLR2K POLR2F | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-211000 | 0.0144900342557 | 1.0 | POLR2K POLR2F | Gene Silencing by RNA |
| REAC:R-HSA-162599 | 0.0147112561527 | 1.0 | POLR2K POLR2F | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168255 | 0.0158425044898 | 1.0 | POLR2K POLR2F | Influenza Life Cycle |
| REAC:R-HSA-9018519 | 0.0165413645736 | 1.0 | POLR2K POLR2F | Estrogen-dependent gene expression |
| REAC:R-HSA-162587 | 0.0177396498492 | 1.0 | POLR2K POLR2F | HIV Life Cycle |
| REAC:R-HSA-212165 | 0.0177396498492 | 1.0 | POLR2K POLR2F | Epigenetic regulation of gene expression |
| REAC:R-HSA-168254 | 0.0182306954237 | 1.0 | POLR2K POLR2F | Influenza Infection |
| GO:0001055 | 0.020287053512 | 1.0 | POLR2K POLR2F | RNA polymerase II activity |
| REAC:R-HSA-72163 | 0.0264008223028 | 1.0 | POLR2K POLR2F | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.0288342631702 | 1.0 | POLR2K POLR2F | mRNA Splicing |
| REAC:R-HSA-8939211 | 0.0347016712119 | 1.0 | POLR2K POLR2F | ESR-mediated signaling |
| GO:0005665 | 0.0351642260875 | 1.0 | POLR2K POLR2F | RNA polymerase II, core complex |
| GO:0001054 | 0.0351642260875 | 1.0 | POLR2K POLR2F | RNA polymerase I activity |
| GO:0005736 | 0.0351642260875 | 1.0 | POLR2K POLR2F | RNA polymerase I complex |
| REAC:R-HSA-162906 | 0.0414841334642 | 1.0 | POLR2K POLR2F | HIV Infection |
| REAC:R-HSA-72203 | 0.046079515598 | 1.0 | POLR2K POLR2F | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-9006931 | 0.0496844269656 | 1.0 | POLR2K POLR2F | Signaling by Nuclear Receptors |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLR2F | POLR2K | 0.94 | 0.852 | hein_WMM bioplex_WMM fraction |
Images
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Complex HuMAP2_04513 has an average edge precision of 0.852 which is ranked 756 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| POLR2F | HuMAP2_00232 HuMAP2_02562 HuMAP2_04513 HuMAP2_05090 HuMAP2_05703 HuMAP2_05762 HuMAP2_05766 |
| POLR2K | HuMAP2_04513 HuMAP2_05090 HuMAP2_05762 |