hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04522
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SCFD1 | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | UniProt NCBI |
| BNIP1 | Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) (Transformation-related gene 8 protein) (TRG-8) | UniProt NCBI |
| STX18 | Syntaxin-18 (Cell growth-inhibiting gene 9 protein) | UniProt NCBI |
| SEC22B | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) | UniProt NCBI |
| BET1 | BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04130 | 4.17116504798e-09 | 0.8 | SEC22B BNIP1 STX18 BET1 | SNARE interactions in vesicular transport |
| REAC:R-HSA-199991 | 1.32997889958e-05 | 1.0 | BET1 SEC22B STX18 BNIP1 SCFD1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 1.74043834947e-05 | 1.0 | BET1 SEC22B STX18 BNIP1 SCFD1 | Vesicle-mediated transport |
| GO:0031201 | 1.98600319243e-05 | 0.8 | SEC22B BNIP1 STX18 BET1 | SNARE complex |
| REAC:R-HSA-204005 | 9.72902207652e-05 | 0.6 | SEC22B SCFD1 BET1 | COPII-mediated vesicle transport |
| GO:0006890 | 0.000245904002808 | 0.8 | SEC22B BNIP1 STX18 SCFD1 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| GO:0048193 | 0.000263126327576 | 1.0 | BET1 SEC22B STX18 BNIP1 SCFD1 | Golgi vesicle transport |
| REAC:R-HSA-6811434 | 0.000384877154433 | 0.6 | SEC22B STX18 BNIP1 | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-8856688 | 0.000960389260783 | 0.6 | SEC22B STX18 BNIP1 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-199977 | 0.00130639580421 | 0.6 | SEC22B SCFD1 BET1 | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 0.00211299613483 | 0.6 | SEC22B SCFD1 BET1 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-6811442 | 0.00334585987792 | 0.6 | SEC22B STX18 BNIP1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0005484 | 0.00367721278555 | 0.6 | SEC22B BET1 BNIP1 | SNAP receptor activity |
| GO:0006888 | 0.0054619312421 | 0.8 | BET1 SEC22B STX18 SCFD1 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| GO:0061024 | 0.00600585321961 | 1.0 | BET1 SEC22B STX18 BNIP1 SCFD1 | membrane organization |
| REAC:R-HSA-446203 | 0.0100880466408 | 0.6 | SEC22B SCFD1 BET1 | Asparagine N-linked glycosylation |
| GO:0048208 | 0.0308999432136 | 0.6 | SEC22B SCFD1 BET1 | COPII vesicle coating |
| GO:0048207 | 0.0308999432136 | 0.6 | SEC22B SCFD1 BET1 | vesicle targeting, rough ER to cis-Golgi |
| GO:0006901 | 0.0376065209581 | 0.6 | SEC22B SCFD1 BET1 | vesicle coating |
| KEGG:04145 | 0.0381461453689 | 0.4 | SEC22B STX18 | Phagosome |
| GO:0090114 | 0.0412952841175 | 0.6 | SEC22B SCFD1 BET1 | COPII-coated vesicle budding |
| GO:0048280 | 0.0450641792523 | 0.4 | SEC22B BET1 | vesicle fusion with Golgi apparatus |
| GO:0048199 | 0.0452171392335 | 0.6 | SEC22B SCFD1 BET1 | vesicle targeting, to, from or within Golgi |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BNIP1 | STX18 | 0.999 | 0.945 | hein_WMM bioplex (STX18) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| STX18 | SEC22B | 0.856 | 0.793 | bioplex (SEC22B,STX18) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| STX18 | SCFD1 | 0.663 | 0.698 | hein_WMM bioplex (STX18) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| BET1 | STX18 | 0.574 | 0.656 | bioplex (STX18) bioplex_WMM youn_WMM gupta_WMM |
| BNIP1 | SEC22B | 0.283 | 0.488 | bioplex (SEC22B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SEC22B | SCFD1 | 0.15 | 0.409 | hein_WMM bioplex (SEC22B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| BET1 | SEC22B | 0.06 | 0.336 | hein_WMM bioplex (SEC22B) bioplex_WMM youn_WMM gupta_WMM |
| BNIP1 | SCFD1 | 0.016 | 0.161 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| BET1 | BNIP1 | 0.008 | 0.068 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| BET1 | SCFD1 | 0.007 | 0.004 | bioplex (BET1) bioplex_WMM youn_WMM gupta_WMM |
Images
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Complex HuMAP2_04522 has an average edge precision of 0.456 which is ranked 2832 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SCFD1 | HuMAP2_00854 HuMAP2_02093 HuMAP2_02979 HuMAP2_04522 |
| BNIP1 | HuMAP2_00854 HuMAP2_02070 HuMAP2_02979 HuMAP2_04522 HuMAP2_06258 |
| STX18 | HuMAP2_00854 HuMAP2_02070 HuMAP2_02979 HuMAP2_04522 HuMAP2_06258 |
| SEC22B | HuMAP2_00854 HuMAP2_02070 HuMAP2_02979 HuMAP2_04522 HuMAP2_06376 |
| BET1 | HuMAP2_00766 HuMAP2_00854 HuMAP2_02979 HuMAP2_04522 HuMAP2_06376 |