hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04528

Confidence: Medium High

Genename	Protein Name	Links
CHMP5	Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60)	UniProt NCBI
CHMP4A	Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1)	UniProt NCBI
CHMP1A	Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1)	UniProt NCBI
CHMP4B	Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2)	UniProt NCBI
STMN4	Stathmin-4 (Stathmin-like protein B3) (RB3)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1186	3.81057767206e-11	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	ESCRT-III complex
GO:0061952	2.90104413489e-07	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	midbody abscission
GO:1902410	8.91404751529e-07	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	mitotic cytokinetic process
GO:0046755	1.54127830699e-06	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	viral budding
KEGG:04217	2.46326526745e-06	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	Necroptosis
GO:0036258	3.33813219873e-06	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	multivesicular body assembly
GO:0036257	3.83246409504e-06	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	multivesicular body organization
GO:0032506	6.37612051417e-06	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	cytokinetic process
REAC:R-HSA-162588	8.88541585136e-06	0.6	CHMP5 CHMP4B CHMP4A	Budding and maturation of HIV virion
GO:0019068	1.00139303444e-05	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	virion assembly
REAC:R-HSA-917729	1.21879917622e-05	0.6	CHMP5 CHMP4B CHMP4A	Endosomal Sorting Complex Required For Transport (ESCRT)
KEGG:04144	1.32635921507e-05	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	Endocytosis
GO:0007080	1.65230232484e-05	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	mitotic metaphase plate congression
GO:0051310	4.1487149847e-05	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	metaphase plate congression
GO:0051303	5.93016865488e-05	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	establishment of chromosome localization
GO:0050000	6.3459788413e-05	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	chromosome localization
GO:0000281	9.31770903001e-05	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	mitotic cytokinesis
GO:0000815	0.000108905457596	0.6	CHMP4A CHMP4B CHMP1A	ESCRT III complex
GO:0007032	0.000111444253056	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	endosome organization
GO:0006997	0.000339213476695	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	nucleus organization
GO:0061640	0.000339213476695	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	cytoskeleton-dependent cytokinesis
GO:1901673	0.000739960245213	0.6	CHMP5 CHMP4B CHMP1A	regulation of mitotic spindle assembly
REAC:R-HSA-162599	0.00102865345201	0.6	CHMP5 CHMP4B CHMP4A	Late Phase of HIV Life Cycle
GO:0039702	0.00120569794977	0.6	CHMP4A CHMP4B CHMP1A	viral budding via host ESCRT complex
REAC:R-HSA-162587	0.00136170542712	0.6	CHMP5 CHMP4B CHMP4A	HIV Life Cycle
GO:0000070	0.00180327283687	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	mitotic sister chromatid segregation
GO:0090169	0.00183428165932	0.6	CHMP5 CHMP4B CHMP1A	regulation of spindle assembly
GO:1902115	0.00196556700855	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	regulation of organelle assembly
GO:0036452	0.00208420080219	0.6	CHMP4A CHMP4B CHMP1A	ESCRT complex
GO:0070507	0.00238666327137	0.8	CHMP5 STMN4 CHMP4B CHMP1A	regulation of microtubule cytoskeleton organization
GO:0000910	0.00245191852964	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	cytokinesis
GO:0000819	0.00360020272665	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	sister chromatid segregation
GO:0032886	0.00445866218218	0.8	CHMP5 STMN4 CHMP4B CHMP1A	regulation of microtubule-based process
REAC:R-HSA-9615710	0.00472180750517	0.4	CHMP4A CHMP4B	Microautophagy
REAC:R-HSA-162906	0.00484900153486	0.6	CHMP5 CHMP4B CHMP4A	HIV Infection
GO:0060236	0.00541762673764	0.6	CHMP5 CHMP4B CHMP1A	regulation of mitotic spindle organization
GO:0010824	0.00541762673764	0.6	CHMP5 CHMP4B CHMP1A	regulation of centrosome duplication
GO:0090224	0.00703245670927	0.6	CHMP5 CHMP4B CHMP1A	regulation of spindle organization
GO:0016197	0.00780704088192	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	endosomal transport
GO:0051301	0.00896454920435	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	cell division
GO:0098813	0.00896454920435	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	nuclear chromosome segregation
GO:0140014	0.0129837343661	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	mitotic nuclear division
GO:0046605	0.0146610377831	0.6	CHMP5 CHMP4B CHMP1A	regulation of centrosome cycle
GO:0019058	0.0151765771023	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	viral life cycle
GO:0007059	0.0197450207423	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	chromosome segregation
REAC:R-HSA-5663205	0.0198891654246	0.6	CHMP5 CHMP4B CHMP4A	Infectious disease
GO:0090307	0.0199719657189	0.6	CHMP5 CHMP4B CHMP1A	mitotic spindle assembly
GO:0051298	0.0250406933376	0.6	CHMP5 CHMP4B CHMP1A	centrosome duplication
GO:0016050	0.0252719643298	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	vesicle organization
GO:0000280	0.0441192366731	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	nuclear division
GO:0051656	0.0470565437665	0.8	CHMP5 CHMP1A CHMP4B CHMP4A	establishment of organelle localization
GO:0033043	0.0493060665482	1.0	CHMP5 CHMP1A STMN4 CHMP4B CHMP4A	regulation of organelle organization
REAC:R-HSA-1632852	0.0499209306556	0.4	CHMP4A CHMP4B	Macroautophagy

Edges

Protein 1	Protein 2	Score	Precision	Evidence
CHMP5	CHMP4A	0.988	0.901	hein_WMM bioplex_WMM Guru fraction
CHMP5	CHMP4B	0.944	0.856	hein_WMM bioplex (CHMP5) bioplex_WMM Guru youn_WMM hein (CHMP4B) gupta_WMM fraction
CHMP5	STMN4	0.153	0.411	bioplex (CHMP5) bioplex_WMM
CHMP4B	CHMP1A	0.049	0.295	hein_WMM bioplex_WMM hein (CHMP4B)
CHMP5	CHMP1A	0.024	0.214	hein_WMM bioplex (CHMP5) bioplex_WMM
STMN4	CHMP1A	0.007	0.006	bioplex_WMM WMM_only
CHMP4B	STMN4	0.007	0.006	bioplex_WMM WMM_only
CHMP4A	CHMP1A	0.007	0.005	hein_WMM WMM_only
CHMP4A	CHMP4B	0.006	0.008	hein_WMM bioplex_WMM hein (CHMP4B) treiber_WMM

Images

Click to enlarge

Complex HuMAP2_04528 has an average edge precision of 0.3 which is ranked 4590 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CHMP5	HuMAP2_00024 HuMAP2_01637 HuMAP2_04528 HuMAP2_06627
CHMP4A	HuMAP2_00024 HuMAP2_01637 HuMAP2_04528 HuMAP2_06627
CHMP1A	HuMAP2_03424 HuMAP2_04165 HuMAP2_04361 HuMAP2_04528
CHMP4B	HuMAP2_00024 HuMAP2_00246 HuMAP2_01637 HuMAP2_03424 HuMAP2_04165 HuMAP2_04361 HuMAP2_04528
STMN4	HuMAP2_00024 HuMAP2_04528 HuMAP2_06627

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_04528