hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04529

Confidence: Medium High

Genename	Protein Name	Links
SMNDC1	Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1)	UniProt NCBI
WRN	Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2)	UniProt NCBI
DENR	Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3)	UniProt NCBI
XRCC6	X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)	UniProt NCBI
XRCC5	X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))	UniProt NCBI
XRCC4	DNA repair protein XRCC4 (X-ray repair cross-complementing protein 4)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:4082	2.25356268047e-09	0.5	XRCC6 XRCC5 WRN	XRCC6-XRCC5-WRN complex
CORUM:5235	9.01288868683e-09	0.5	XRCC6 XRCC5 WRN	WRN-Ku70-Ku80-PARP1 complex
WP:WP438	5.25079226446e-08	0.5	XRCC6 XRCC5 XRCC4	Non-homologous end joining
CORUM:1189	7.88270302729e-08	0.5	XRCC6 XRCC5 XRCC4	DNA double-strand break end-joining complex
REAC:R-HSA-164843	2.08310119344e-07	0.5	XRCC6 XRCC5 XRCC4	2-LTR circle formation
KEGG:03450	4.80275654775e-07	0.5	XRCC6 XRCC5 XRCC4	Non-homologous end-joining
REAC:R-HSA-162592	4.99793187022e-07	0.5	XRCC6 XRCC5 XRCC4	Integration of provirus
REAC:R-HSA-162594	2.16413418261e-06	0.5	XRCC6 XRCC5 XRCC4	Early Phase of HIV Life Cycle
CORUM:328	8.39001385941e-06	0.333333333333	XRCC6 XRCC5	Ku antigen complex
CORUM:4081	8.39001385941e-06	0.333333333333	XRCC6 XRCC5	Ku antigen complex
CORUM:6310	2.51655344529e-05	0.333333333333	XRCC6 XRCC5	DEAF1- complex
CORUM:2918	2.51655344529e-05	0.333333333333	XRCC6 XRCC5	Ku antigen-YY1-alphaMyHC promoter complex
CORUM:1220	2.51655344529e-05	0.333333333333	XRCC6 XRCC5	TRF2-Ku complex
CORUM:1092	2.51655344529e-05	0.333333333333	XRCC6 XRCC5	PCNA-KU antigen complex
CORUM:357	2.51655344529e-05	0.333333333333	XRCC6 XRCC5	DNA-PK-Ku complex
CORUM:356	2.51655344529e-05	0.333333333333	XRCC6 XRCC5	DNA-PK-Ku complex
CORUM:355	2.51655344529e-05	0.333333333333	XRCC6 XRCC5	DNA-PK-Ku complex
CORUM:5182	2.51655344529e-05	0.333333333333	XRCC6 XRCC5	DNA-PK-Ku complex
CORUM:95	2.51655344529e-05	0.333333333333	XRCC6 XRCC5	Ku antigen-NARG1 complex
CORUM:322	2.51655344529e-05	0.333333333333	XRCC6 XRCC5	DNA-PK-Ku complex
REAC:R-HSA-5693532	3.42582751834e-05	0.666666666667	XRCC4 XRCC6 XRCC5 WRN	DNA Double-Strand Break Repair
CORUM:1571	5.0322056017e-05	0.333333333333	XRCC6 XRCC5	Vigilin-DNA-PK-Ku antigen complex
CORUM:5176	5.0322056017e-05	0.333333333333	XRCC6 XRCC5	MGC1-DNA-PKcs-Ku complex
CORUM:7217	5.0322056017e-05	0.333333333333	XRCC6 XRCC5	Dysbindin 1-A-DNA-PK-complex
CORUM:5179	8.38550741504e-05	0.333333333333	XRCC6 XRCC5	NCOA6-DNA-PK-Ku-PARP1 complex
CORUM:5231	8.38550741504e-05	0.333333333333	XRCC6 XRCC5	53BP1-containing complex
GO:0075713	0.000101639975642	0.5	XRCC6 XRCC5 XRCC4	establishment of integrated proviral latency
CORUM:3102	0.000125760085813	0.333333333333	XRCC6 XRCC5	DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex
CORUM:5251	0.000125760085813	0.333333333333	XRCC6 XRCC5	Ku-ORC complex
GO:0019043	0.000152436922042	0.5	XRCC6 XRCC5 XRCC4	establishment of viral latency
GO:0070419	0.000152436922042	0.5	XRCC6 XRCC5 XRCC4	nonhomologous end joining complex
CORUM:2766	0.000176032589326	0.333333333333	XRCC6 XRCC5	TERF2-RAP1 complex
CORUM:1193	0.000176032589326	0.333333333333	XRCC6 XRCC5	Rap1 complex
CORUM:5183	0.000234668084372	0.333333333333	XRCC6 XRCC5	DNA-PK-Ku-eIF2-NF90-NF45 complex
GO:0019042	0.000299339163023	0.5	XRCC6 XRCC5 XRCC4	viral latency
CORUM:7285	0.000301662071994	0.333333333333	XRCC6 XRCC5	HEXIM1-DNA-PK-paraspeckle components-ribonucleoprotein complex
REAC:R-HSA-5693571	0.000308922066904	0.5	XRCC6 XRCC5 XRCC4	Nonhomologous End-Joining (NHEJ)
REAC:R-HSA-73894	0.000503324377427	0.666666666667	XRCC4 XRCC6 XRCC5 WRN	DNA Repair
GO:0010165	0.000660060925697	0.5	XRCC6 XRCC5 XRCC4	response to X-ray
GO:0010212	0.000770248195723	0.666666666667	XRCC4 XRCC6 XRCC5 WRN	response to ionizing radiation
GO:0071480	0.00123252169378	0.5	XRCC6 XRCC5 WRN	cellular response to gamma radiation
REAC:R-HSA-3270619	0.00172598429993	0.333333333333	XRCC6 XRCC5	IRF3-mediated induction of type I IFN
REAC:R-HSA-1834941	0.00265393377546	0.333333333333	XRCC6 XRCC5	STING mediated induction of host immune responses
REAC:R-HSA-162587	0.00296089666153	0.5	XRCC6 XRCC5 XRCC4	HIV Life Cycle
GO:0010332	0.00366468326223	0.5	XRCC6 XRCC5 WRN	response to gamma radiation
GO:1990391	0.00986527098502	0.5	XRCC6 XRCC5 XRCC4	DNA repair complex
REAC:R-HSA-162906	0.0105025954201	0.5	XRCC6 XRCC5 XRCC4	HIV Infection
GO:0042162	0.0129043378459	0.5	XRCC6 XRCC5 WRN	telomeric DNA binding
WP:WP4016	0.0165558163549	0.333333333333	XRCC5 WRN	DNA IR-damage and cellular response via ATR
GO:0043564	0.020283420769	0.333333333333	XRCC6 XRCC5	Ku70:Ku80 complex
GO:0071479	0.0273937790841	0.5	XRCC6 XRCC5 WRN	cellular response to ionizing radiation
GO:0006302	0.0398596812877	0.666666666667	XRCC4 XRCC6 XRCC5 WRN	double-strand break repair
REAC:R-HSA-5663205	0.0427834850779	0.5	XRCC6 XRCC5 XRCC4	Infectious disease
REAC:R-HSA-1834949	0.0428303754683	0.333333333333	XRCC6 XRCC5	Cytosolic sensors of pathogen-associated DNA
CORUM:354	0.0499726005494	0.166666666667	XRCC4	DNA ligase IV-XRCC4 complex
CORUM:352	0.0499726005494	0.166666666667	XRCC4	DNA ligase IV-XRCC4 complex
CORUM:348	0.0499726005494	0.166666666667	XRCC4	DNA ligase IV-XRCC4 complex
CORUM:345	0.0499726005494	0.166666666667	XRCC4	DNA ligase IV-XRCC4 complex
CORUM:206	0.0499726005494	0.166666666667	XRCC4	DNA ligase IV-XRCC4 complex
CORUM:7282	0.0499726005494	0.166666666667	WRN	FEN1-WRN complex
CORUM:1217	0.0499726005494	0.166666666667	WRN	WRN-TRF2 complex
CORUM:344	0.0499726005494	0.166666666667	XRCC4	DNA ligase IV-XRCC4 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
XRCC5	XRCC6	1.0	0.949	hein_WMM bioplex (XRCC6) bioplex_WMM Guru boldt youn_WMM hein (XRCC5,XRCC6) Malo gupta_WMM fraction boldt_WMM treiber_WMM
XRCC6	WRN	0.999	0.949	hein_WMM bioplex (XRCC6) bioplex_WMM boldt youn_WMM hein (XRCC6) boldt_WMM
XRCC4	XRCC6	0.205	0.454	hein_WMM bioplex_WMM boldt youn_WMM hein (XRCC6) gupta_WMM fraction boldt_WMM
SMNDC1	XRCC6	0.156	0.416	bioplex_WMM youn_WMM gupta_WMM fraction
XRCC5	SMNDC1	0.14	0.407	bioplex_WMM youn_WMM gupta_WMM fraction
DENR	XRCC6	0.061	0.334	bioplex (DENR) bioplex_WMM youn_WMM gupta_WMM fraction
DENR	XRCC5	0.009	0.101	bioplex (DENR) bioplex_WMM youn_WMM gupta_WMM fraction
XRCC4	XRCC5	0.009	0.101	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction
XRCC4	WRN	0.008	0.09	hein_WMM youn_WMM WMM_only
XRCC4	SMNDC1	0.007	0.008	youn_WMM gupta_WMM WMM_only
SMNDC1	WRN	0.007	0.005	youn_WMM WMM_only
XRCC5	WRN	0.006	0.009	hein_WMM bioplex_WMM boldt youn_WMM hein (XRCC5) boldt_WMM
DENR	WRN	0.005	0.008	fraction
DENR	XRCC4	0.004	0.009	fraction
DENR	SMNDC1	0.003	0.011	bioplex_WMM gupta_WMM fraction

Images

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Complex HuMAP2_04529 has an average edge precision of 0.257 which is ranked 5275 out of all 6965 complexes.

Related Complexes

Genename	Complexes
SMNDC1	HuMAP2_01667 HuMAP2_02358 HuMAP2_02551 HuMAP2_04529 HuMAP2_05682 HuMAP2_06648
WRN	HuMAP2_02284 HuMAP2_02836 HuMAP2_03086 HuMAP2_04529 HuMAP2_05224 HuMAP2_05863 HuMAP2_06682
DENR	HuMAP2_00371 HuMAP2_00668 HuMAP2_00950 HuMAP2_01992 HuMAP2_04529 HuMAP2_06314 HuMAP2_06768
XRCC6	HuMAP2_02284 HuMAP2_02836 HuMAP2_03086 HuMAP2_04529 HuMAP2_05224 HuMAP2_05793 HuMAP2_05863 HuMAP2_06682
XRCC5	HuMAP2_01370 HuMAP2_01667 HuMAP2_02284 HuMAP2_02836 HuMAP2_04529 HuMAP2_05793
XRCC4	HuMAP2_00890 HuMAP2_02785 HuMAP2_02808 HuMAP2_04235 HuMAP2_04529 HuMAP2_05206

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04529