hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04533
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) | UniProt NCBI |
| ORC3 | Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) | UniProt NCBI |
| ORC5 | Origin recognition complex subunit 5 | UniProt NCBI |
| ORC4 | Origin recognition complex subunit 4 | UniProt NCBI |
| ORC6 | Origin recognition complex subunit 6 | UniProt NCBI |
| ORC2 | Origin recognition complex subunit 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000808 | 9.24336013776e-17 | 1.0 | ORC3 ORC6 ORC2 ORC5 ORC4 LRWD1 | origin recognition complex |
| GO:0005664 | 9.24336013776e-17 | 1.0 | ORC3 ORC6 ORC2 ORC5 ORC4 LRWD1 | nuclear origin of replication recognition complex |
| CORUM:389 | 3.65872083369e-16 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | ORC complex (origin recognition complex) |
| CORUM:1033 | 3.65872083369e-16 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | ORC complex (origin recognition complex) |
| CORUM:1031 | 3.65872083369e-16 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | ORC complex (origin recognition complex) |
| REAC:R-HSA-68616 | 9.66861964574e-16 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | Assembly of the ORC complex at the origin of replication |
| REAC:R-HSA-113507 | 2.03006918199e-14 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | E2F-enabled inhibition of pre-replication complex formation |
| REAC:R-HSA-68689 | 7.44275358293e-14 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | CDC6 association with the ORC:origin complex |
| CORUM:1034 | 4.54011687692e-13 | 0.666666666667 | ORC2 ORC3 ORC5 ORC4 | ORC 2-5 complex (origin recognition 2-5 complex) |
| GO:0006270 | 1.96017005921e-12 | 1.0 | ORC3 ORC6 ORC2 ORC5 ORC4 LRWD1 | DNA replication initiation |
| CORUM:1038 | 2.26981451009e-12 | 0.666666666667 | ORC2 ORC3 ORC5 ORC4 | ORC 1-5 complex (origin recognition 1-5 complex) |
| REAC:R-HSA-113510 | 4.23975677772e-12 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | E2F mediated regulation of DNA replication |
| CORUM:5251 | 6.80871178609e-12 | 0.666666666667 | ORC2 ORC3 ORC4 ORC6 | Ku-ORC complex |
| WP:WP466 | 3.44835361196e-11 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | DNA Replication |
| REAC:R-HSA-68962 | 3.81873931614e-11 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | Activation of the pre-replicative complex |
| REAC:R-HSA-176187 | 7.01201572048e-11 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | Activation of ATR in response to replication stress |
| WP:WP45 | 2.84592842322e-10 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | G1 to S cell cycle control |
| REAC:R-HSA-68827 | 8.04354101299e-10 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | CDT1 association with the CDC6:ORC:origin complex |
| REAC:R-HSA-68867 | 1.67395276865e-09 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | Assembly of the pre-replicative complex |
| GO:0003688 | 2.08691658479e-09 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | DNA replication origin binding |
| REAC:R-HSA-68949 | 2.09044250377e-09 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | Orc1 removal from chromatin |
| CORUM:1032 | 2.25356268047e-09 | 0.5 | ORC3 ORC4 ORC2 | ORC 2-4 complex (origin recognition 2-4 complex) |
| REAC:R-HSA-69002 | 5.26238367222e-09 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | DNA Replication Pre-Initiation |
| WP:WP179 | 6.47472566592e-09 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | Cell Cycle |
| REAC:R-HSA-69052 | 6.65761939932e-09 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | Switching of origins to a post-replicative state |
| KEGG:04110 | 8.61751518462e-09 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | Cell cycle |
| GO:0006261 | 1.70651556121e-08 | 1.0 | ORC3 ORC6 ORC2 ORC5 ORC4 LRWD1 | DNA-dependent DNA replication |
| REAC:R-HSA-69239 | 2.80175002575e-08 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | Synthesis of DNA |
| REAC:R-HSA-69306 | 3.90905948705e-08 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | DNA Replication |
| REAC:R-HSA-69206 | 4.58062236292e-08 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | G1/S Transition |
| REAC:R-HSA-453279 | 8.53743828436e-08 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | Mitotic G1-G1/S phases |
| REAC:R-HSA-69242 | 1.26971687219e-07 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | S Phase |
| REAC:R-HSA-69481 | 1.62719833986e-07 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | G2/M Checkpoints |
| GO:0006260 | 3.45239368596e-07 | 1.0 | ORC3 ORC6 ORC2 ORC5 ORC4 LRWD1 | DNA replication |
| REAC:R-HSA-69620 | 2.48510366679e-06 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | Cell Cycle Checkpoints |
| GO:0000781 | 1.96143444342e-05 | 0.833333333333 | ORC2 ORC3 ORC4 LRWD1 ORC5 | chromosome, telomeric region |
| REAC:R-HSA-69278 | 4.68016887558e-05 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | Cell Cycle, Mitotic |
| REAC:R-HSA-1640170 | 0.000115024964847 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | Cell Cycle |
| GO:0000082 | 0.000126408450622 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | G1/S transition of mitotic cell cycle |
| GO:0044843 | 0.000169291065803 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | cell cycle G1/S phase transition |
| GO:0006259 | 0.000579923761468 | 1.0 | ORC3 ORC6 ORC2 ORC5 ORC4 LRWD1 | DNA metabolic process |
| GO:0098687 | 0.000589670352383 | 0.833333333333 | ORC2 ORC3 ORC4 LRWD1 ORC5 | chromosomal region |
| GO:0043565 | 0.000937137248598 | 1.0 | ORC3 ORC6 ORC2 ORC5 ORC4 LRWD1 | sequence-specific DNA binding |
| GO:0000784 | 0.00277382255858 | 0.666666666667 | ORC2 ORC3 ORC5 ORC4 | nuclear chromosome, telomeric region |
| GO:0044454 | 0.00288133296855 | 1.0 | ORC3 ORC6 ORC2 ORC5 ORC4 LRWD1 | nuclear chromosome part |
| HP:0011267 | 0.00337633448894 | 0.333333333333 | ORC4 ORC6 | Microtia, third degree |
| HP:0009892 | 0.00337633448894 | 0.333333333333 | ORC4 ORC6 | Anotia |
| HP:0003561 | 0.00337633448894 | 0.333333333333 | ORC4 ORC6 | Birth length less than 3rd percentile |
| GO:0000228 | 0.0033810209942 | 1.0 | ORC3 ORC6 ORC2 ORC5 ORC4 LRWD1 | nuclear chromosome |
| HP:0009939 | 0.00412589193299 | 0.333333333333 | ORC4 ORC6 | Mandibular aplasia |
| HP:0100783 | 0.00787106080828 | 0.333333333333 | ORC4 ORC6 | Breast aplasia |
| HP:0006443 | 0.00787106080828 | 0.333333333333 | ORC4 ORC6 | Patellar aplasia |
| HP:0002780 | 0.00787106080828 | 0.333333333333 | ORC4 ORC6 | Bronchomalacia |
| GO:0044772 | 0.00886141193647 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | mitotic cell cycle phase transition |
| HP:0006660 | 0.0101912456166 | 0.333333333333 | ORC4 ORC6 | Aplastic clavicle |
| GO:0044770 | 0.0121980983176 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | cell cycle phase transition |
| GO:0044427 | 0.0151552637177 | 1.0 | ORC3 ORC6 ORC2 ORC5 ORC4 LRWD1 | chromosomal part |
| HP:0000064 | 0.0172946302375 | 0.333333333333 | ORC4 ORC6 | Hypoplastic labia minora |
| GO:0003677 | 0.0183905219298 | 1.0 | ORC3 ORC6 ORC2 ORC5 ORC4 LRWD1 | DNA binding |
| GO:0005694 | 0.0188325821521 | 1.0 | ORC3 ORC6 ORC2 ORC5 ORC4 LRWD1 | chromosome |
| HP:0000060 | 0.0189383441407 | 0.333333333333 | ORC4 ORC6 | Clitoral hypoplasia |
| HP:0040255 | 0.0189383441407 | 0.333333333333 | ORC4 ORC6 | Aplasia/Hypoplasia of the clitoris |
| HP:0000039 | 0.0189383441407 | 0.333333333333 | ORC4 ORC6 | Epispadias |
| HP:0002779 | 0.0262553193116 | 0.333333333333 | ORC4 ORC6 | Tracheomalacia |
| HP:0012880 | 0.0282698926051 | 0.333333333333 | ORC4 ORC6 | Abnormality of the labia minora |
| GO:1990837 | 0.028320562987 | 0.833333333333 | ORC6 ORC3 ORC2 ORC5 ORC4 | sequence-specific double-stranded DNA binding |
| HP:0006498 | 0.030358517586 | 0.333333333333 | ORC4 ORC6 | Aplasia/Hypoplasia of the patella |
| HP:0000059 | 0.034757762481 | 0.333333333333 | ORC4 ORC6 | Hypoplastic labia majora |
| HP:0003187 | 0.034757762481 | 0.333333333333 | ORC4 ORC6 | Breast hypoplasia |
| HP:0003100 | 0.0370683023611 | 0.333333333333 | ORC4 ORC6 | Slender long bone |
| HP:0012881 | 0.044443111782 | 0.333333333333 | ORC4 ORC6 | Abnormality of the labia majora |
| CORUM:2205 | 0.0499726005494 | 0.166666666667 | ORC5 | ORC5-ORC1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LRWD1 | ORC2 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (LRWD1,ORC2) Malo gupta_WMM fraction |
| ORC6 | ORC2 | 0.702 | 0.723 | bioplex (ORC6) bioplex_WMM |
| LRWD1 | ORC5 | 0.157 | 0.416 | hein_WMM bioplex_WMM youn_WMM hein (LRWD1) gupta_WMM |
| ORC3 | ORC2 | 0.109 | 0.378 | bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| ORC5 | ORC2 | 0.066 | 0.35 | hein_WMM bioplex_WMM youn_WMM hein (ORC2) gupta_WMM |
| LRWD1 | ORC4 | 0.025 | 0.211 | hein_WMM bioplex_WMM youn_WMM hein (LRWD1) gupta_WMM |
| LRWD1 | ORC6 | 0.02 | 0.188 | bioplex (ORC6) bioplex_WMM |
| ORC6 | ORC3 | 0.009 | 0.107 | Guru fraction |
| LRWD1 | ORC3 | 0.008 | 0.078 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ORC3 | ORC4 | 0.007 | 0.01 | youn_WMM gupta_WMM WMM_only |
| ORC2 | ORC4 | 0.007 | 0.001 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ORC5 | ORC4 | 0.007 | 0.005 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ORC5 | ORC3 | 0.0 | 0.0 | youn_WMM gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_04533 has an average edge precision of 0.263 which is ranked 5183 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LRWD1 | HuMAP2_00864 HuMAP2_02551 HuMAP2_04398 HuMAP2_04533 |
| ORC3 | HuMAP2_00864 HuMAP2_01115 HuMAP2_02994 HuMAP2_04533 HuMAP2_04597 |
| ORC5 | HuMAP2_00864 HuMAP2_04533 |
| ORC4 | HuMAP2_04444 HuMAP2_04533 HuMAP2_04924 |
| ORC6 | HuMAP2_00864 HuMAP2_02994 HuMAP2_04398 HuMAP2_04533 |
| ORC2 | HuMAP2_00864 HuMAP2_02994 HuMAP2_04398 HuMAP2_04533 HuMAP2_04597 |