hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04543
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NDUFB11 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (CI-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit) (Neuronal protein 17.3) (Np17.3) (p17.3) | UniProt NCBI |
| NDUFB6 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (Complex I-B17) (CI-B17) (NADH-ubiquinone oxidoreductase B17 subunit) | UniProt NCBI |
| NDUFB5 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit) | UniProt NCBI |
| NDUFB3 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (CI-B12) (NADH-ubiquinone oxidoreductase B12 subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2914 | 6.18958015715e-11 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Respiratory chain complex I (beta subunit) mitochondrial |
| CORUM:178 | 4.14407128617e-09 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Respiratory chain complex I (holoenzyme), mitochondrial |
| WP:WP4324 | 4.43703742416e-09 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Mitochondrial complex I assembly model OXPHOS system |
| REAC:R-HSA-6799198 | 2.455200129e-08 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Complex I biogenesis |
| KEGG:00190 | 1.38672231517e-07 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Oxidative phosphorylation |
| KEGG:05012 | 1.80872757791e-07 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Parkinson disease |
| WP:WP4396 | 2.1280005727e-07 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Nonalcoholic fatty liver disease |
| KEGG:04723 | 2.18345424274e-07 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Retrograde endocannabinoid signaling |
| KEGG:04932 | 2.25115825027e-07 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Non-alcoholic fatty liver disease (NAFLD) |
| REAC:R-HSA-611105 | 2.76558694195e-07 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Respiratory electron transport |
| KEGG:05010 | 4.07191302063e-07 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Alzheimer disease |
| REAC:R-HSA-163200 | 6.49361324137e-07 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:05016 | 6.98090734098e-07 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Huntington disease |
| KEGG:04714 | 1.39576721349e-06 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Thermogenesis |
| REAC:R-HSA-1428517 | 2.70008667352e-06 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0005747 | 3.31172184909e-06 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | mitochondrial respiratory chain complex I |
| GO:0045271 | 3.31172184909e-06 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | respiratory chain complex I |
| GO:0030964 | 3.31172184909e-06 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | NADH dehydrogenase complex |
| GO:0006120 | 3.63481666364e-06 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | mitochondrial electron transport, NADH to ubiquinone |
| GO:0010257 | 1.27309456693e-05 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | NADH dehydrogenase complex assembly |
| GO:0032981 | 1.27309456693e-05 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | mitochondrial respiratory chain complex I assembly |
| GO:0098803 | 1.98673792316e-05 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | respiratory chain complex |
| GO:0005746 | 2.10899871844e-05 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | mitochondrial respirasome |
| GO:0070469 | 2.65528608423e-05 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | respirasome |
| WP:WP111 | 2.91471848583e-05 | 0.75 | NDUFB6 NDUFB5 NDUFB3 | Electron Transport Chain (OXPHOS system in mitochondria) |
| GO:0042775 | 3.47984386015e-05 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 3.66543553269e-05 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | ATP synthesis coupled electron transport |
| GO:1990204 | 5.68877655611e-05 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | oxidoreductase complex |
| GO:0033108 | 6.2335294411e-05 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | mitochondrial respiratory chain complex assembly |
| GO:0022904 | 6.52012849586e-05 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | respiratory electron transport chain |
| GO:0022900 | 6.81649797295e-05 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | electron transport chain |
| GO:0098800 | 0.000162788555852 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | inner mitochondrial membrane protein complex |
| GO:0006119 | 0.000193719078201 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | oxidative phosphorylation |
| GO:0045333 | 0.000419088323416 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | cellular respiration |
| GO:0044455 | 0.00100892420578 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | mitochondrial membrane part |
| GO:0015980 | 0.00157802566628 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | energy derivation by oxidation of organic compounds |
| WP:WP623 | 0.00248310593375 | 0.5 | NDUFB6 NDUFB5 | Oxidative phosphorylation |
| GO:0098798 | 0.00297010167954 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | mitochondrial protein complex |
| GO:0008137 | 0.00305917975424 | 0.75 | NDUFB6 NDUFB5 NDUFB3 | NADH dehydrogenase (ubiquinone) activity |
| GO:0003954 | 0.00305917975424 | 0.75 | NDUFB6 NDUFB5 NDUFB3 | NADH dehydrogenase activity |
| GO:0050136 | 0.00305917975424 | 0.75 | NDUFB6 NDUFB5 NDUFB3 | NADH dehydrogenase (quinone) activity |
| GO:0046034 | 0.00312639352664 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | ATP metabolic process |
| GO:0016655 | 0.0080085486554 | 0.75 | NDUFB6 NDUFB5 NDUFB3 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| HP:0012748 | 0.00986303631958 | 0.5 | NDUFB11 NDUFB3 | Focal T2 hyperintense brainstem lesion |
| HP:0008316 | 0.0105423007107 | 0.5 | NDUFB11 NDUFB3 | Abnormal mitochondria in muscle tissue |
| HP:0012747 | 0.0127153557137 | 0.5 | NDUFB11 NDUFB3 | Abnormal brainstem MRI signal intensity |
| HP:0025116 | 0.0134847743701 | 0.5 | NDUFB11 NDUFB3 | Fetal distress |
| HP:0011923 | 0.0134847743701 | 0.5 | NDUFB11 NDUFB3 | Decreased activity of mitochondrial complex I |
| HP:0007704 | 0.0134847743701 | 0.5 | NDUFB11 NDUFB3 | Paroxysmal involuntary eye movements |
| HP:0000114 | 0.0150911756538 | 0.5 | NDUFB11 NDUFB3 | Proximal tubulopathy |
| GO:0005743 | 0.0166033324327 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | mitochondrial inner membrane |
| HP:0004366 | 0.0176695962482 | 0.5 | NDUFB11 NDUFB3 | Abnormality of glycolysis |
| HP:0003542 | 0.0176695962482 | 0.5 | NDUFB11 NDUFB3 | Increased serum pyruvate |
| GO:0006091 | 0.0197812720484 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | generation of precursor metabolites and energy |
| GO:0019866 | 0.0226824675867 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | organelle inner membrane |
| HP:0011013 | 0.023433582519 | 0.5 | NDUFB11 NDUFB3 | Abnormal circulating carbohydrate concentration |
| HP:0003737 | 0.0300060012618 | 0.5 | NDUFB11 NDUFB3 | Mitochondrial myopathy |
| HP:0001138 | 0.0300060012618 | 0.5 | NDUFB11 NDUFB3 | Optic neuropathy |
| GO:0007005 | 0.0330068688285 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | mitochondrion organization |
| GO:0016651 | 0.037022076332 | 0.75 | NDUFB6 NDUFB5 NDUFB3 | oxidoreductase activity, acting on NAD(P)H |
| HP:0008972 | 0.0413775694569 | 0.5 | NDUFB11 NDUFB3 | Decreased activity of mitochondrial respiratory chain |
| GO:0055114 | 0.0422401319933 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | oxidation-reduction process |
| HP:0011922 | 0.0427529847392 | 0.5 | NDUFB11 NDUFB3 | Abnormal activity of mitochondrial respiratory chain |
| HP:0000817 | 0.0441507593067 | 0.5 | NDUFB11 NDUFB3 | Poor eye contact |
| REAC:R-HSA-1430728 | 0.0467536218007 | 1.0 | NDUFB3 NDUFB6 NDUFB11 NDUFB5 | Metabolism |
| HP:0003800 | 0.0470133620262 | 0.5 | NDUFB11 NDUFB3 | Muscle abnormality related to mitochondrial dysfunction |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NDUFB11 | NDUFB6 | 0.641 | 0.687 | bioplex (NDUFB11) bioplex_WMM |
| NDUFB11 | NDUFB3 | 0.204 | 0.454 | bioplex (NDUFB11) bioplex_WMM |
| NDUFB5 | NDUFB3 | 0.1 | 0.362 | bioplex (NDUFB5) bioplex_WMM |
| NDUFB11 | NDUFB5 | 0.086 | 0.352 | bioplex (NDUFB11,NDUFB5) bioplex_WMM |
| NDUFB6 | NDUFB5 | 0.086 | 0.351 | bioplex (NDUFB5) bioplex_WMM |
| NDUFB6 | NDUFB3 | 0.017 | 0.173 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04543 has an average edge precision of 0.397 which is ranked 3364 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NDUFB11 | HuMAP2_00091 HuMAP2_01373 HuMAP2_01573 HuMAP2_01600 HuMAP2_02247 HuMAP2_02525 HuMAP2_04543 HuMAP2_06566 |
| NDUFB6 | HuMAP2_00091 HuMAP2_01573 HuMAP2_01600 HuMAP2_04543 |
| NDUFB5 | HuMAP2_00306 HuMAP2_00917 HuMAP2_01373 HuMAP2_01573 HuMAP2_01600 HuMAP2_02247 HuMAP2_04543 |
| NDUFB3 | HuMAP2_00917 HuMAP2_01573 HuMAP2_01600 HuMAP2_04543 |