hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04548

Confidence: Very High

Genename	Protein Name	Links
DLD	Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)	UniProt NCBI
PDHX	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	UniProt NCBI
MRPS36	28S ribosomal protein S36, mitochondrial (MRP-S36) (S36mt)	UniProt NCBI
DLAT	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)	UniProt NCBI
OGDHL	2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.-) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like)	UniProt NCBI
DLST	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)	UniProt NCBI
OGDH	2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0045252	3.61183144291e-12	0.714285714286	DLST DLD OGDHL OGDH MRPS36	oxoglutarate dehydrogenase complex
GO:1990204	9.85356801999e-12	1.0	DLD DLST MRPS36 OGDH DLAT PDHX OGDHL	oxidoreductase complex
KEGG:00020	2.1357056588e-11	0.714285714286	DLST DLD OGDHL DLAT OGDH	Citrate cycle (TCA cycle)
GO:0045240	7.94247119785e-11	0.714285714286	DLST DLD OGDHL OGDH MRPS36	dihydrolipoyl dehydrogenase complex
REAC:R-HSA-389661	8.17619328953e-11	0.714285714286	OGDH DLD DLST PDHX DLAT	Glyoxylate metabolism and glycine degradation
GO:0016903	1.03694962029e-10	0.857142857143	DLD MRPS36 OGDH DLAT PDHX OGDHL	oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0045239	2.21205005828e-10	0.714285714286	DLST DLD OGDHL OGDH MRPS36	tricarboxylic acid cycle enzyme complex
REAC:R-HSA-71406	1.48746221904e-09	0.714285714286	OGDH DLD DLST PDHX DLAT	Pyruvate metabolism and Citric Acid (TCA) cycle
WP:WP2453	1.64999296982e-09	0.571428571429	DLD DLST DLAT OGDH	TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc)
CORUM:7267	1.3523445861e-08	0.428571428571	DLD OGDH DLST	KAT2A-Oxoglutarate dehydrogenase complex
KEGG:01200	2.61503713754e-08	0.714285714286	DLST DLD OGDHL DLAT OGDH	Carbon metabolism
REAC:R-HSA-1428517	5.41747192787e-07	0.714285714286	OGDH DLD DLST PDHX DLAT	The citric acid (TCA) cycle and respiratory electron transport
WP:WP3925	2.08961610056e-06	0.571428571429	DLD DLST PDHX OGDH	Amino Acid metabolism
WP:WP78	2.29297025836e-06	0.428571428571	DLD OGDH DLST	TCA Cycle (aka Krebs or citric acid cycle)
REAC:R-HSA-71064	2.33456820519e-06	0.428571428571	DLD OGDH DLST	Lysine catabolism
REAC:R-HSA-204174	5.93774784282e-06	0.428571428571	DLD PDHX DLAT	Regulation of pyruvate dehydrogenase (PDH) complex
GO:0004591	1.27120391093e-05	0.428571428571	MRPS36 OGDH OGDHL	oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0106077	1.27120391093e-05	0.428571428571	DLD OGDH DLST	histone succinylation
GO:0034604	1.27120391093e-05	0.428571428571	DLD PDHX DLAT	pyruvate dehydrogenase (NAD+) activity
GO:0018335	1.27120391093e-05	0.428571428571	DLD OGDH DLST	protein succinylation
GO:0034603	1.27120391093e-05	0.428571428571	DLD PDHX DLAT	pyruvate dehydrogenase [NAD(P)+] activity
REAC:R-HSA-71403	1.40879428916e-05	0.428571428571	DLD OGDH DLST	Citric acid cycle (TCA cycle)
REAC:R-HSA-71291	2.32006456929e-05	0.714285714286	OGDH DLD DLST PDHX DLAT	Metabolism of amino acids and derivatives
GO:0006099	2.33016882025e-05	0.571428571429	DLD DLST OGDH OGDHL	tricarboxylic acid cycle
REAC:R-HSA-70268	3.86423784685e-05	0.428571428571	DLD PDHX DLAT	Pyruvate metabolism
GO:0045254	6.35345863999e-05	0.428571428571	DLD PDHX DLAT	pyruvate dehydrogenase complex
GO:0004738	6.35345863999e-05	0.428571428571	DLD PDHX DLAT	pyruvate dehydrogenase activity
REAC:R-HSA-5362517	0.000104252987625	0.428571428571	DLD PDHX DLAT	Signaling by Retinoic Acid
KEGG:01100	0.000138040728497	0.857142857143	DLD DLAT OGDH DLST PDHX OGDHL	Metabolic pathways
GO:0005759	0.000141443350129	0.857142857143	DLD DLST MRPS36 OGDH DLAT PDHX	mitochondrial matrix
GO:0016624	0.000177825159425	0.428571428571	MRPS36 OGDH OGDHL	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HP:0003128	0.000206040598494	0.571428571429	OGDH DLD PDHX DLAT	Lactic acidosis
WP:WP4236	0.000211266711219	0.285714285714	PDHX DLST	Disorders of the Krebs cycle
HP:0012401	0.000692418575536	0.285714285714	DLD OGDH	Abnormal urine alpha-ketoglutarate concentration
GO:0006554	0.000698035893352	0.428571428571	DLD OGDH DLST	lysine catabolic process
GO:0009060	0.000868835004821	0.571428571429	DLD DLST OGDH OGDHL	aerobic respiration
GO:0006553	0.000907263777246	0.428571428571	DLD OGDH DLST	lysine metabolic process
GO:0005739	0.000929815577583	1.0	DLD DLST MRPS36 OGDH DLAT PDHX OGDHL	mitochondrion
GO:0016491	0.000973515580853	0.857142857143	DLD MRPS36 OGDH DLAT PDHX OGDHL	oxidoreductase activity
GO:1902494	0.00105300999874	1.0	DLD DLST MRPS36 OGDH DLAT PDHX OGDHL	catalytic complex
GO:0006103	0.00115446662879	0.428571428571	MRPS36 OGDH DLST	2-oxoglutarate metabolic process
GO:0006637	0.0013339504969	0.571428571429	DLD DLST PDHX OGDH	acyl-CoA metabolic process
GO:0035383	0.0013339504969	0.571428571429	DLD DLST PDHX OGDH	thioester metabolic process
HP:0001941	0.00267758979755	0.571428571429	OGDH DLD PDHX DLAT	Acidosis
HP:0004360	0.00378730054633	0.571428571429	OGDH DLD PDHX DLAT	Abnormality of acid-base homeostasis
HP:0001942	0.00403972366653	0.428571428571	DLD PDHX OGDH	Metabolic acidosis
GO:0009068	0.00421229492459	0.428571428571	DLD OGDH DLST	aspartate family amino acid catabolic process
GO:0033875	0.00484567677782	0.571428571429	DLD DLST PDHX OGDH	ribonucleoside bisphosphate metabolic process
GO:0034032	0.00484567677782	0.571428571429	DLD DLST PDHX OGDH	purine nucleoside bisphosphate metabolic process
GO:0033865	0.00484567677782	0.571428571429	DLD DLST PDHX OGDH	nucleoside bisphosphate metabolic process
KEGG:00380	0.00655764034054	0.285714285714	DLD DLST	Tryptophan metabolism
KEGG:00620	0.00729284489491	0.285714285714	DLD DLAT	Pyruvate metabolism
GO:0044429	0.00742049328708	0.857142857143	DLD DLST MRPS36 OGDH DLAT PDHX	mitochondrial part
GO:0051186	0.00832517533845	0.714285714286	OGDH DLD DLST PDHX MRPS36	cofactor metabolic process
GO:0019752	0.00899876078428	0.857142857143	DLD DLST MRPS36 OGDH DLAT PDHX	carboxylic acid metabolic process
WP:WP534	0.00943851998861	0.285714285714	DLD DLAT	Glycolysis and Gluconeogenesis
HP:0003287	0.0103685612154	0.428571428571	DLD PDHX DLAT	Abnormality of mitochondrial metabolism
GO:0016620	0.0142076090165	0.428571428571	DLD PDHX DLAT	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0045333	0.0143396670291	0.571428571429	DLD DLST OGDH OGDHL	cellular respiration
GO:0043436	0.0147858371095	0.857142857143	DLD DLST MRPS36 OGDH DLAT PDHX	oxoacid metabolic process
GO:0006082	0.016122709633	0.857142857143	DLD DLST MRPS36 OGDH DLAT PDHX	organic acid metabolic process
HP:0012103	0.0176082521898	0.428571428571	DLD PDHX DLAT	Abnormality of the mitochondrion
KEGG:00310	0.01792209342	0.285714285714	DLD DLST	Lysine degradation
KEGG:00010	0.0191181203407	0.285714285714	DLD DLAT	Glycolysis / Gluconeogenesis
REAC:R-HSA-9006931	0.0242125809602	0.428571428571	DLD PDHX DLAT	Signaling by Nuclear Receptors
HPA:008050_12	0.0254707353033	0.428571428571	MRPS36 OGDH DLST	cerebral cortex; neuropil[Supported,Medium]
GO:0061732	0.0283955176165	0.285714285714	DLD PDHX	mitochondrial acetyl-CoA biosynthetic process from pyruvate
GO:0009066	0.0389125948999	0.428571428571	DLD OGDH DLST	aspartate family amino acid metabolic process

Edges

Protein 1	Protein 2	Score	Precision	Evidence
OGDH	DLST	1.0	0.949	hein_WMM bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM
OGDH	DLD	1.0	0.949	hein_WMM bioplex (DLD) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM
OGDHL	DLD	1.0	0.949	bioplex (DLD) bioplex_WMM
DLD	DLAT	1.0	0.949	hein_WMM bioplex (DLD) bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM
OGDH	DLAT	1.0	0.949	hein_WMM bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM
DLST	DLAT	1.0	0.949	hein_WMM bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM
DLD	MRPS36	1.0	0.949	hein_WMM bioplex (DLD) bioplex_WMM youn_WMM fraction
DLST	DLD	1.0	0.949	hein_WMM bioplex (DLD) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM treiber_WMM
DLD	PDHX	0.909	0.832	hein_WMM bioplex (DLD,PDHX) bioplex_WMM youn_WMM
PDHX	DLAT	0.062	0.341	hein_WMM bioplex (PDHX) bioplex_WMM
DLST	MRPS36	0.012	0.15	hein_WMM bioplex_WMM youn_WMM WMM_only
OGDH	MRPS36	0.011	0.142	hein_WMM bioplex_WMM youn_WMM WMM_only
MRPS36	DLAT	0.009	0.106	hein_WMM bioplex_WMM youn_WMM WMM_only
DLST	PDHX	0.008	0.094	hein_WMM bioplex (PDHX) bioplex_WMM
OGDH	OGDHL	0.008	0.091	bioplex_WMM WMM_only
DLST	OGDHL	0.008	0.089	bioplex_WMM WMM_only
OGDHL	MRPS36	0.008	0.083	bioplex_WMM WMM_only
MRPS36	PDHX	0.008	0.083	hein_WMM bioplex_WMM WMM_only
OGDHL	DLAT	0.008	0.07	bioplex_WMM WMM_only
OGDHL	PDHX	0.008	0.028	bioplex_WMM WMM_only
OGDH	PDHX	0.007	0.004	hein_WMM bioplex_WMM WMM_only

Images

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Complex HuMAP2_04548 has an average edge precision of 0.462 which is ranked 2785 out of all 6965 complexes.

Related Complexes

Genename	Complexes
DLD	HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633
PDHX	HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06086
MRPS36	HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633
DLAT	HuMAP2_04548 HuMAP2_06086 HuMAP2_06633
OGDHL	HuMAP2_01514 HuMAP2_02654 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633
DLST	HuMAP2_00982 HuMAP2_04548 HuMAP2_06633
OGDH	HuMAP2_00982 HuMAP2_04548 HuMAP2_06633

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04548