hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04550
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSD17B10 | 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) | UniProt NCBI |
| ACSL5 | Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5) | UniProt NCBI |
| HADH | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) | UniProt NCBI |
| CUTA | Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor) | UniProt NCBI |
| UPP1 | Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3) | UniProt NCBI |
| ECHS1 | Enoyl-CoA hydratase, mitochondrial (EC 4.2.1.17) (Enoyl-CoA hydratase 1) (Short-chain enoyl-CoA hydratase) (SCEH) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP357 | 2.30511528619e-06 | 0.5 | HADH ACSL5 ECHS1 | Fatty Acid Biosynthesis |
| WP:WP143 | 8.94077488385e-06 | 0.5 | HADH ACSL5 ECHS1 | Fatty Acid Beta Oxidation |
| WP:WP465 | 1.25967140138e-05 | 0.5 | HADH HSD17B10 ECHS1 | Tryptophan metabolism |
| KEGG:00071 | 1.91938138598e-05 | 0.5 | HADH ACSL5 ECHS1 | Fatty acid degradation |
| KEGG:00280 | 2.70899139624e-05 | 0.5 | HADH HSD17B10 ECHS1 | Valine, leucine and isoleucine degradation |
| KEGG:01212 | 3.91015753854e-05 | 0.5 | HADH ACSL5 ECHS1 | Fatty acid metabolism |
| REAC:R-HSA-77352 | 6.65030189148e-05 | 0.333333333333 | HADH ECHS1 | Beta oxidation of butanoyl-CoA to acetyl-CoA |
| REAC:R-HSA-77348 | 0.000221597343492 | 0.333333333333 | HADH ECHS1 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA |
| REAC:R-HSA-77350 | 0.000221597343492 | 0.333333333333 | HADH ECHS1 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA |
| REAC:R-HSA-77310 | 0.000221597343492 | 0.333333333333 | HADH ECHS1 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA |
| REAC:R-HSA-77346 | 0.000332336489066 | 0.333333333333 | HADH ECHS1 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA |
| REAC:R-HSA-77286 | 0.000797179114843 | 0.333333333333 | HADH ECHS1 | mitochondrial fatty acid beta-oxidation of saturated fatty acids |
| KEGG:01100 | 0.0012193073463 | 0.833333333333 | HADH UPP1 ACSL5 ECHS1 HSD17B10 | Metabolic pathways |
| KEGG:00650 | 0.00157819534506 | 0.333333333333 | HADH ECHS1 | Butanoate metabolism |
| KEGG:00062 | 0.00157819534506 | 0.333333333333 | HADH ECHS1 | Fatty acid elongation |
| REAC:R-HSA-8978868 | 0.00340713657136 | 0.5 | HADH ACSL5 ECHS1 | Fatty acid metabolism |
| KEGG:00380 | 0.00414404804148 | 0.333333333333 | HADH ECHS1 | Tryptophan metabolism |
| HP:0012103 | 0.00923202229008 | 0.5 | HADH HSD17B10 ECHS1 | Abnormality of the mitochondrion |
| KEGG:00310 | 0.0113378999483 | 0.333333333333 | HADH ECHS1 | Lysine degradation |
| REAC:R-HSA-77289 | 0.0116417903194 | 0.333333333333 | HADH ECHS1 | Mitochondrial Fatty Acid Beta-Oxidation |
| REAC:R-HSA-1430728 | 0.0278608311428 | 0.833333333333 | HADH UPP1 ACSL5 ECHS1 HSD17B10 | Metabolism |
| HP:0001639 | 0.033266345548 | 0.5 | HADH HSD17B10 ECHS1 | Hypertrophic cardiomyopathy |
| CORUM:7429 | 0.0499726005494 | 0.166666666667 | HSD17B10 | HSD17B10-TRMT10C complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UPP1 | CUTA | 0.668 | 0.701 | bioplex (CUTA) bioplex_WMM |
| UPP1 | ECHS1 | 0.326 | 0.515 | fraction treiber_WMM |
| UPP1 | HADH | 0.081 | 0.35 | fraction treiber_WMM |
| ACSL5 | HSD17B10 | 0.068 | 0.347 | fraction |
| ACSL5 | HADH | 0.066 | 0.347 | fraction |
| HADH | HSD17B10 | 0.061 | 0.339 | bioplex_WMM youn_WMM fraction treiber_WMM |
| ECHS1 | HADH | 0.049 | 0.296 | bioplex_WMM youn_WMM fraction treiber_WMM |
| HSD17B10 | CUTA | 0.007 | 0.005 | bioplex (CUTA) |
| HADH | CUTA | 0.006 | 0.007 | bioplex (CUTA) bioplex_WMM |
| ECHS1 | CUTA | 0.0 | 0.012 | fraction |
| ECHS1 | HSD17B10 | 0.0 | 0.001 | bioplex (ECHS1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| UPP1 | HSD17B10 | 0.0 | 0.001 | fraction treiber_WMM |
Images
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Complex HuMAP2_04550 has an average edge precision of 0.243 which is ranked 5478 out of all 6965 complexes.
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