hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04552
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TNKS | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) | UniProt NCBI |
| TNKS2 | Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein) | UniProt NCBI |
| AACS | Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) | UniProt NCBI |
| FAM117B | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | UniProt NCBI |
| IMMP1L | Mitochondrial inner membrane protease subunit 1 (EC 3.4.21.-) (IMP1-like protein) | UniProt NCBI |
| GMDS | GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5545619 | 2.21716431826e-05 | 0.333333333333 | TNKS TNKS2 | XAV939 inhibits tankyrase, stabilizing AXIN |
| CORUM:1219 | 2.51655344529e-05 | 0.333333333333 | TNKS TNKS2 | Tankyrin 1-tankyrin 2-TRF1 complex |
| WP:WP3645 | 0.000952765433858 | 0.333333333333 | TNKS TNKS2 | NAD+ biosynthetic pathways |
| REAC:R-HSA-4791275 | 0.00959640616298 | 0.333333333333 | TNKS TNKS2 | Signaling by WNT in cancer |
| REAC:R-HSA-4641257 | 0.0326136400052 | 0.333333333333 | TNKS TNKS2 | Degradation of AXIN |
| REAC:R-HSA-8948751 | 0.0499130144295 | 0.333333333333 | TNKS TNKS2 | Regulation of PTEN stability and activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TNKS | TNKS2 | 0.475 | 0.609 | hein_WMM bioplex_WMM hein (TNKS,TNKS2) |
| TNKS | GMDS | 0.426 | 0.575 | hein_WMM bioplex (GMDS) bioplex_WMM hein (TNKS) |
| GMDS | TNKS2 | 0.295 | 0.495 | hein_WMM bioplex (GMDS) bioplex_WMM hein (TNKS2) |
| TNKS | FAM117B | 0.074 | 0.356 | bioplex (FAM117B) bioplex_WMM |
| FAM117B | IMMP1L | 0.067 | 0.352 | bioplex (FAM117B) bioplex_WMM |
| TNKS2 | FAM117B | 0.035 | 0.261 | bioplex (FAM117B) bioplex_WMM |
| GMDS | AACS | 0.029 | 0.233 | fraction |
| TNKS | IMMP1L | 0.007 | 0.004 | bioplex_WMM WMM_only |
| TNKS2 | IMMP1L | 0.007 | 0.004 | bioplex_WMM WMM_only |
| GMDS | FAM117B | 0.003 | 0.007 | bioplex (FAM117B) |
Images
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Complex HuMAP2_04552 has an average edge precision of 0.29 which is ranked 4757 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TNKS | HuMAP2_00575 HuMAP2_01652 HuMAP2_04190 HuMAP2_04552 |
| TNKS2 | HuMAP2_01652 HuMAP2_04190 HuMAP2_04552 |
| AACS | HuMAP2_01015 HuMAP2_01617 HuMAP2_03397 HuMAP2_04552 HuMAP2_06471 |
| FAM117B | HuMAP2_02603 HuMAP2_04552 HuMAP2_05742 |
| IMMP1L | HuMAP2_02603 HuMAP2_04552 HuMAP2_05696 HuMAP2_05742 |
| GMDS | HuMAP2_01015 HuMAP2_01652 HuMAP2_04552 HuMAP2_06471 |