hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04556
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DOCK3 | Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) | UniProt NCBI |
| ELMO2 | Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) | UniProt NCBI |
| DOCK4 | Dedicator of cytokinesis protein 4 | UniProt NCBI |
| ELMO1 | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | UniProt NCBI |
| DOCK1 | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8849471 | 7.76884875116e-07 | 0.6 | ELMO2 DOCK1 ELMO1 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
| CORUM:5337 | 6.70868171695e-06 | 0.4 | ELMO1 DOCK1 | ELMO1-DOCK1 complex |
| CORUM:5342 | 2.0123342217e-05 | 0.4 | ELMO1 DOCK1 | ELMO1-DOCK1-RAC1 complex |
| CORUM:5343 | 2.0123342217e-05 | 0.4 | ELMO1 DOCK1 | ELMO1-DOCK1-CRKII complex |
| KEGG:05131 | 3.58157342459e-05 | 0.6 | ELMO2 DOCK1 ELMO1 | Shigellosis |
| REAC:R-HSA-9006927 | 4.10976418258e-05 | 0.6 | ELMO2 DOCK1 ELMO1 | Signaling by Non-Receptor Tyrosine Kinases |
| REAC:R-HSA-8848021 | 4.10976418258e-05 | 0.6 | ELMO2 DOCK1 ELMO1 | Signaling by PTK6 |
| KEGG:05100 | 5.34171113368e-05 | 0.6 | ELMO2 DOCK1 ELMO1 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-2029482 | 8.78979375366e-05 | 0.6 | ELMO2 DOCK1 ELMO1 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-2029480 | 0.000221673564929 | 0.6 | ELMO2 DOCK1 ELMO1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-4420097 | 0.000327410819085 | 0.6 | ELMO2 DOCK1 ELMO1 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-9006934 | 0.000402506828977 | 0.8 | ELMO2 DOCK1 ELMO1 DOCK3 | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-194138 | 0.000422377343701 | 0.6 | ELMO2 DOCK1 ELMO1 | Signaling by VEGF |
| REAC:R-HSA-983231 | 0.00175946619988 | 0.6 | DOCK4 DOCK1 DOCK3 | Factors involved in megakaryocyte development and platelet production |
| CORUM:5341 | 0.0499494897235 | 0.2 | ELMO1 | ELMO1-DOCK2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ELMO1 | DOCK1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| DOCK3 | ELMO1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| DOCK4 | ELMO1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| ELMO2 | ELMO1 | 0.99 | 0.909 | bioplex (ELMO1) bioplex_WMM |
| ELMO2 | DOCK1 | 0.014 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| DOCK4 | DOCK1 | 0.013 | 0.149 | bioplex_WMM youn_WMM WMM_only |
| DOCK4 | ELMO2 | 0.012 | 0.149 | bioplex_WMM youn_WMM WMM_only |
| DOCK3 | DOCK1 | 0.011 | 0.137 | bioplex_WMM WMM_only |
| DOCK4 | DOCK3 | 0.011 | 0.146 | bioplex_WMM WMM_only |
| DOCK3 | ELMO2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04556 has an average edge precision of 0.462 which is ranked 2789 out of all 6965 complexes.
Related Complexes