hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04565
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| APEX1 | DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial] | UniProt NCBI |
| PARP1 | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) | UniProt NCBI |
| YARS | Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-110362 | 0.000187420766709 | 0.666666666667 | APEX1 PARP1 | POLB-Dependent Long Patch Base Excision Repair |
| KEGG:03410 | 0.000221829243661 | 0.666666666667 | APEX1 PARP1 | Base excision repair |
| REAC:R-HSA-110373 | 0.00200655101382 | 0.666666666667 | APEX1 PARP1 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| REAC:R-HSA-73933 | 0.00397787610966 | 0.666666666667 | APEX1 PARP1 | Resolution of Abasic Sites (AP sites) |
| MIRNA:hsa-miR-555 | 0.0108886199752 | 0.666666666667 | YARS PARP1 | hsa-miR-555 |
| REAC:R-HSA-73884 | 0.0249521708712 | 0.666666666667 | APEX1 PARP1 | Base Excision Repair |
| CORUM:7352 | 0.0499776345577 | 0.333333333333 | PARP1 | PARP1-LIG3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| APEX1 | YARS | 0.668 | 0.701 | bioplex (APEX1) bioplex_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| APEX1 | PARP1 | 0.06 | 0.337 | bioplex (APEX1) bioplex_WMM gupta_WMM fraction boldt_WMM |
| PARP1 | YARS | 0.054 | 0.301 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_04565 has an average edge precision of 0.446 which is ranked 2901 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| APEX1 | HuMAP2_00204 HuMAP2_01328 HuMAP2_01654 HuMAP2_04565 HuMAP2_05490 |
| PARP1 | HuMAP2_00550 HuMAP2_00586 HuMAP2_03086 HuMAP2_03648 HuMAP2_04565 HuMAP2_05034 |
| YARS | HuMAP2_02855 HuMAP2_04565 HuMAP2_05490 HuMAP2_05624 |