hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04566
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PTPN2 | Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP) | UniProt NCBI |
| MUTYH | Adenine DNA glycosylase (EC 3.2.2.31) (MutY homolog) (hMYH) | UniProt NCBI |
| COL5A1 | Collagen alpha-1(V) chain | UniProt NCBI |
| COL8A2 | Collagen alpha-2(VIII) chain (Endothelial collagen) | UniProt NCBI |
| COL2A1 | Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8948216 | 2.47599987196e-05 | 0.6 | COL2A1 COL5A1 COL8A2 | Collagen chain trimerization |
| REAC:R-HSA-2022090 | 7.49721357414e-05 | 0.6 | COL2A1 COL5A1 COL8A2 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1442490 | 9.25148000407e-05 | 0.6 | COL2A1 COL5A1 COL8A2 | Collagen degradation |
| REAC:R-HSA-1650814 | 0.00010222685444 | 0.6 | COL2A1 COL5A1 COL8A2 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-6806834 | 0.000167928044622 | 0.6 | PTPN2 COL5A1 COL2A1 | Signaling by MET |
| REAC:R-HSA-216083 | 0.00018227939524 | 0.6 | COL2A1 COL5A1 COL8A2 | Integrin cell surface interactions |
| REAC:R-HSA-1474290 | 0.00025697910325 | 0.6 | COL2A1 COL5A1 COL8A2 | Collagen formation |
| REAC:R-HSA-1474228 | 0.000916592958714 | 0.6 | COL2A1 COL5A1 COL8A2 | Degradation of the extracellular matrix |
| REAC:R-HSA-8874081 | 0.00508433997358 | 0.4 | COL2A1 COL5A1 | MET activates PTK2 signaling |
| HP:0001369 | 0.00640811720481 | 0.6 | PTPN2 COL5A1 COL2A1 | Arthritis |
| GO:0030020 | 0.00646290954968 | 0.6 | COL2A1 COL5A1 COL8A2 | extracellular matrix structural constituent conferring tensile strength |
| REAC:R-HSA-419037 | 0.00666792835349 | 0.4 | COL2A1 COL5A1 | NCAM1 interactions |
| REAC:R-HSA-1474244 | 0.00830412575866 | 0.6 | COL2A1 COL5A1 COL8A2 | Extracellular matrix organization |
| REAC:R-HSA-8875878 | 0.00894729002053 | 0.4 | COL2A1 COL5A1 | MET promotes cell motility |
| HP:0012372 | 0.0107492437093 | 1.0 | PTPN2 MUTYH COL2A1 COL5A1 COL8A2 | Abnormal eye morphology |
| KEGG:04974 | 0.0117982317972 | 0.4 | COL2A1 COL5A1 | Protein digestion and absorption |
| HP:0003040 | 0.0127896924378 | 0.4 | PTPN2 COL2A1 | Arthropathy |
| REAC:R-HSA-375165 | 0.0164283536306 | 0.4 | COL2A1 COL5A1 | NCAM signaling for neurite out-growth |
| REAC:R-HSA-186797 | 0.019180674733 | 0.4 | COL2A1 COL5A1 | Signaling by PDGF |
| REAC:R-HSA-3000171 | 0.0213836497757 | 0.4 | COL2A1 COL5A1 | Non-integrin membrane-ECM interactions |
| HP:0001083 | 0.0229596708254 | 0.4 | COL2A1 COL5A1 | Ectopia lentis |
| REAC:R-HSA-3000178 | 0.0287045163353 | 0.4 | COL2A1 COL5A1 | ECM proteoglycans |
| REAC:R-HSA-9006934 | 0.0291077226575 | 0.6 | PTPN2 COL5A1 COL2A1 | Signaling by Receptor Tyrosine Kinases |
| HP:0000478 | 0.0345715487774 | 1.0 | PTPN2 MUTYH COL2A1 COL5A1 COL8A2 | Abnormality of the eye |
| HP:0001373 | 0.0354679667682 | 0.6 | PTPN2 COL5A1 COL2A1 | Joint dislocation |
| HP:0002758 | 0.0478196851342 | 0.4 | COL2A1 COL5A1 | Osteoarthritis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PTPN2 | COL5A1 | 0.723 | 0.733 | hein_WMM bioplex (PTPN2) bioplex_WMM hein (PTPN2) |
| COL5A1 | COL8A2 | 0.413 | 0.571 | bioplex (COL8A2) bioplex_WMM |
| PTPN2 | MUTYH | 0.311 | 0.504 | bioplex (PTPN2) bioplex_WMM |
| COL8A2 | COL2A1 | 0.077 | 0.352 | bioplex (COL8A2) bioplex_WMM |
| COL5A1 | COL2A1 | 0.012 | 0.146 | bioplex_WMM WMM_only |
| MUTYH | COL5A1 | 0.008 | 0.066 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04566 has an average edge precision of 0.395 which is ranked 3375 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PTPN2 | HuMAP2_00416 HuMAP2_00859 HuMAP2_04566 HuMAP2_04914 |
| MUTYH | HuMAP2_00416 HuMAP2_04566 HuMAP2_04914 |
| COL5A1 | HuMAP2_00859 HuMAP2_04566 HuMAP2_05432 HuMAP2_05533 |
| COL8A2 | HuMAP2_04566 HuMAP2_05161 HuMAP2_05432 HuMAP2_05533 |
| COL2A1 | HuMAP2_04566 HuMAP2_05161 HuMAP2_05432 HuMAP2_05533 |