hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04568
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DCAF11 | DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23) | UniProt NCBI |
| CUL4A | Cullin-4A (CUL-4A) | UniProt NCBI |
| DDB2 | DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1162 | 3.35555483123e-05 | 0.666666666667 | CUL4A DDB2 | Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) |
| CORUM:726 | 0.00022139720913 | 0.666666666667 | CUL4A DDB2 | DDB2 complex |
| KEGG:03420 | 0.000422858026176 | 0.666666666667 | CUL4A DDB2 | Nucleotide excision repair |
| GO:0080008 | 0.000495506150782 | 1.0 | CUL4A DDB2 DCAF11 | Cul4-RING E3 ubiquitin ligase complex |
| REAC:R-HSA-8951664 | 0.000808797867084 | 1.0 | CUL4A DDB2 DCAF11 | Neddylation |
| KEGG:04120 | 0.00373360278335 | 0.666666666667 | CUL4A DDB2 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-5696394 | 0.0046992786316 | 0.666666666667 | CUL4A DDB2 | DNA Damage Recognition in GG-NER |
| REAC:R-HSA-5696400 | 0.00548064029679 | 0.666666666667 | CUL4A DDB2 | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 0.00603484671946 | 0.666666666667 | CUL4A DDB2 | Formation of Incision Complex in GG-NER |
| REAC:R-HSA-5696399 | 0.0232544758505 | 0.666666666667 | CUL4A DDB2 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-5696398 | 0.0399448421955 | 0.666666666667 | CUL4A DDB2 | Nucleotide Excision Repair |
| GO:0031461 | 0.0480789908723 | 1.0 | CUL4A DDB2 DCAF11 | cullin-RING ubiquitin ligase complex |
| CORUM:790 | 0.0499776345577 | 0.333333333333 | DDB2 | DDB complex |
| CORUM:2171 | 0.0499776345577 | 0.333333333333 | CUL4A | Ubiquitin E3 ligase (CHEK1, CUL4A) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DDB2 | CUL4A | 0.993 | 0.917 | hein_WMM bioplex (DDB2) bioplex_WMM hein (DDB2) boldt_WMM |
| CUL4A | DCAF11 | 0.931 | 0.846 | hein_WMM bioplex (DCAF11) bioplex_WMM boldt hein (CUL4A) boldt_WMM |
| DDB2 | DCAF11 | 0.01 | 0.102 | hein_WMM bioplex_WMM WMM_only boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_04568 has an average edge precision of 0.622 which is ranked 1817 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DCAF11 | HuMAP2_04568 HuMAP2_06808 |
| CUL4A | HuMAP2_04568 HuMAP2_06808 |
| DDB2 | HuMAP2_04142 HuMAP2_04568 HuMAP2_06808 |