hu.MAP 2.0: Complex View

Human Protein Complex Map

Genename	Protein Name	Links
AFF1	AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)	UniProt NCBI
MLLT1	Protein ENL (YEATS domain-containing protein 1)	UniProt NCBI
AFF4	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)	UniProt NCBI
EAF2	ELL-associated factor 2 (Testosterone-regulated apoptosis inducer and tumor suppressor protein)	UniProt NCBI
ICE1	Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1)	UniProt NCBI
EAF1	ELL-associated factor 1	UniProt NCBI
ELL3	RNA polymerase II elongation factor ELL3	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6084	8.44943744452e-14	0.714285714286	MLLT1 ELL3 EAF1 AFF1 AFF4	AFF4 super elongation complex (SEC)
GO:0008023	1.55035512047e-13	1.0	MLLT1 EAF1 EAF2 ELL3 AFF4 ICE1 AFF1	transcription elongation factor complex
REAC:R-HSA-112382	1.28820166004e-06	0.571428571429	MLLT1 EAF1 EAF2 AFF4	Formation of RNA Pol II elongation complex
REAC:R-HSA-75955	1.28820166004e-06	0.571428571429	MLLT1 EAF1 EAF2 AFF4	RNA Polymerase II Transcription Elongation
GO:0006368	3.84509079134e-06	0.714285714286	MLLT1 ELL3 EAF1 EAF2 AFF4	transcription elongation from RNA polymerase II promoter
REAC:R-HSA-674695	4.93220962918e-06	0.571428571429	MLLT1 EAF1 EAF2 AFF4	RNA Polymerase II Pre-transcription Events
GO:0006354	1.64259579769e-05	0.714285714286	MLLT1 ELL3 EAF1 EAF2 AFF4	DNA-templated transcription, elongation
CORUM:1457	3.02079974644e-05	0.285714285714	MLLT1 AFF1	AFF1-MLLT1-CBX8 complex
GO:0044451	0.000166634167312	1.0	MLLT1 EAF1 EAF2 ELL3 AFF4 ICE1 AFF1	nucleoplasm part
REAC:R-HSA-73857	0.00023249479605	0.857142857143	MLLT1 EAF1 ELL3 AFF4 ICE1 EAF2	RNA Polymerase II Transcription
REAC:R-HSA-74160	0.000444522787502	0.857142857143	MLLT1 EAF1 ELL3 AFF4 ICE1 EAF2	Gene expression (Transcription)
GO:0032783	0.0283955176165	0.285714285714	AFF4 AFF1	ELL-EAF complex
CORUM:0000000	0.0437772681198	0.857142857143	MLLT1 EAF1 EAF2 ELL3 AFF4 AFF1	CORUM root

Protein 1	Protein 2	Score	Precision	Evidence
EAF1	ELL3	0.998	0.945	bioplex (EAF1,ELL3) bioplex_WMM
MLLT1	AFF4	0.997	0.93	hein_WMM bioplex_WMM youn_WMM hein (MLLT1) Malo fraction
EAF2	ELL3	0.995	0.923	bioplex (ELL3) bioplex_WMM
AFF4	ELL3	0.981	0.896	bioplex (AFF4,ELL3) bioplex_WMM
ICE1	EAF1	0.966	0.876	bioplex (EAF1) bioplex_WMM
EAF2	EAF1	0.891	0.819	bioplex (EAF1) bioplex_WMM
AFF1	ELL3	0.877	0.811	bioplex (ELL3) bioplex_WMM
MLLT1	ELL3	0.876	0.811	bioplex (ELL3) bioplex_WMM
ICE1	ELL3	0.74	0.739	bioplex (ELL3) bioplex_WMM
AFF4	EAF1	0.342	0.531	bioplex (AFF4,EAF1) bioplex_WMM fraction
AFF1	MLLT1	0.155	0.415	hein_WMM bioplex_WMM hein (AFF1,MLLT1)
MLLT1	EAF1	0.113	0.38	bioplex (EAF1) bioplex_WMM fraction
AFF1	AFF4	0.079	0.353	hein_WMM bioplex_WMM hein (AFF1)
EAF2	AFF4	0.05	0.296	bioplex (AFF4) bioplex_WMM
AFF1	EAF1	0.014	0.137	bioplex (EAF1) bioplex_WMM
AFF1	EAF2	0.012	0.145	bioplex_WMM WMM_only
MLLT1	EAF2	0.011	0.141	bioplex_WMM WMM_only
EAF2	ICE1	0.011	0.142	bioplex_WMM WMM_only
AFF1	ICE1	0.01	0.131	bioplex_WMM WMM_only
ICE1	AFF4	0.01	0.12	bioplex_WMM youn_WMM WMM_only
MLLT1	ICE1	0.01	0.104	bioplex_WMM WMM_only

Click to enlarge

Complex HuMAP2_04584 has an average edge precision of 0.507 which is ranked 2458 out of all 6965 complexes.