hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04587
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ZBTB12 | Zinc finger and BTB domain-containing protein 12 (Protein G10) | UniProt NCBI |
| APBB1IP | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) | UniProt NCBI |
| PTK2 | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | UniProt NCBI |
| ZNF281 | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | UniProt NCBI |
| PLEKHH2 | Pleckstrin homology domain-containing family H member 2 | UniProt NCBI |
| PLEKHH1 | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) | UniProt NCBI |
| LPXN | Leupaxin | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-354194 | 0.00287361887808 | 0.285714285714 | APBB1IP PTK2 | GRB2:SOS provides linkage to MAPK signaling for Integrins |
| REAC:R-HSA-372708 | 0.00331497172198 | 0.285714285714 | APBB1IP PTK2 | p130Cas linkage to MAPK signaling for integrins |
| REAC:R-HSA-354192 | 0.00869609533822 | 0.285714285714 | APBB1IP PTK2 | Integrin alphaIIb beta3 signaling |
| REAC:R-HSA-9006921 | 0.00869609533822 | 0.285714285714 | APBB1IP PTK2 | Integrin signaling |
| REAC:R-HSA-76009 | 0.0136873957341 | 0.285714285714 | APBB1IP PTK2 | Platelet Aggregation (Plug Formation) |
| CORUM:2256 | 0.0499886427319 | 0.142857142857 | APBB1IP | RIAM-Rap1-GTP complex |
| CORUM:3159 | 0.0499886427319 | 0.142857142857 | APBB1IP | RIAM-profilin complex |
| CORUM:3160 | 0.0499886427319 | 0.142857142857 | APBB1IP | RIAM-VASP complex |
| CORUM:5712 | 0.0499886427319 | 0.142857142857 | PTK2 | FAK-beta5 integrin complex, VEGF induced |
| CORUM:7116 | 0.0499886427319 | 0.142857142857 | PTK2 | GRB7-PTK2 complex |
| CORUM:7416 | 0.0499886427319 | 0.142857142857 | PTK2 | GJB2-PTK2-NANOG complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PTK2 | LPXN | 0.551 | 0.644 | bioplex (LPXN) bioplex_WMM |
| LPXN | PLEKHH2 | 0.351 | 0.537 | bioplex (LPXN) bioplex_WMM |
| PLEKHH1 | LPXN | 0.088 | 0.353 | bioplex (LPXN) bioplex_WMM |
| LPXN | ZBTB12 | 0.066 | 0.347 | bioplex (LPXN) bioplex_WMM |
| LPXN | ZNF281 | 0.053 | 0.301 | bioplex (LPXN) bioplex_WMM |
| APBB1IP | PLEKHH1 | 0.04 | 0.267 | bioplex (APBB1IP) |
| PLEKHH2 | ZBTB12 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| PTK2 | PLEKHH2 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| PLEKHH1 | PLEKHH2 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| PLEKHH1 | ZBTB12 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| PTK2 | ZBTB12 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| PLEKHH1 | PTK2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| PLEKHH2 | ZNF281 | 0.008 | 0.009 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ZBTB12 | ZNF281 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| PLEKHH1 | ZNF281 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| PTK2 | ZNF281 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| APBB1IP | ZNF281 | 0.007 | 0.003 | youn_WMM WMM_only |
Images
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Complex HuMAP2_04587 has an average edge precision of 0.173 which is ranked 6501 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ZBTB12 | HuMAP2_04587 |
| APBB1IP | HuMAP2_00454 HuMAP2_04587 HuMAP2_06847 |
| PTK2 | HuMAP2_01133 HuMAP2_04587 HuMAP2_04999 |
| ZNF281 | HuMAP2_04587 |
| PLEKHH2 | HuMAP2_04587 |
| PLEKHH1 | HuMAP2_00454 HuMAP2_04587 HuMAP2_06847 |
| LPXN | HuMAP2_01133 HuMAP2_04587 |