hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04588
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RNASEH2A | Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) | UniProt NCBI |
| RNASEH2C | Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0200149 | 7.01280862145e-05 | 1.0 | RNASEH2C RNASEH2A | CSF lymphocytic pleiocytosis |
| HP:0030356 | 7.01280862145e-05 | 1.0 | RNASEH2C RNASEH2A | Increased serum interferon-gamma level |
| HP:0012229 | 7.01280862145e-05 | 1.0 | RNASEH2C RNASEH2A | CSF pleocytosis |
| HP:0009710 | 7.01280862145e-05 | 1.0 | RNASEH2C RNASEH2A | Chilblains |
| HP:0009709 | 7.01280862145e-05 | 1.0 | RNASEH2C RNASEH2A | Increased CSF interferon alpha |
| HP:0009704 | 7.01280862145e-05 | 1.0 | RNASEH2C RNASEH2A | Chronic CSF lymphocytosis |
| KEGG:03030 | 9.19154528054e-05 | 1.0 | RNASEH2C RNASEH2A | DNA replication |
| HP:0040140 | 9.35041149526e-05 | 1.0 | RNASEH2C RNASEH2A | Degeneration of the striatum |
| HP:0005550 | 9.35041149526e-05 | 1.0 | RNASEH2C RNASEH2A | Chronic lymphatic leukemia |
| HP:0001955 | 9.35041149526e-05 | 1.0 | RNASEH2C RNASEH2A | Unexplained fevers |
| HP:0030355 | 0.000120219576368 | 1.0 | RNASEH2C RNASEH2A | Abnormal serum interferon-gamma level |
| HP:0030354 | 0.000120219576368 | 1.0 | RNASEH2C RNASEH2A | Abnormal serum interferon level |
| HP:0011834 | 0.00015027447046 | 1.0 | RNASEH2C RNASEH2A | Moyamoya phenomenon |
| HP:0007052 | 0.00015027447046 | 1.0 | RNASEH2C RNASEH2A | Multifocal cerebral white matter abnormalities |
| HP:0004809 | 0.000220402556674 | 1.0 | RNASEH2C RNASEH2A | Neonatal alloimmune thrombocytopenia |
| HP:0003683 | 0.000260475748797 | 1.0 | RNASEH2C RNASEH2A | Large beaked nose |
| HP:0007076 | 0.000260475748797 | 1.0 | RNASEH2C RNASEH2A | Extrapyramidal muscular rigidity |
| HP:0011112 | 0.000303888373596 | 1.0 | RNASEH2C RNASEH2A | Abnormality of serum cytokine level |
| HP:0030038 | 0.000350640431072 | 1.0 | RNASEH2C RNASEH2A | Enchondroma |
| HP:0011111 | 0.000350640431072 | 1.0 | RNASEH2C RNASEH2A | Abnormality of immune serum protein physiology |
| HP:0004963 | 0.000400731921226 | 1.0 | RNASEH2C RNASEH2A | Calcification of the aorta |
| HP:0005558 | 0.000400731921226 | 1.0 | RNASEH2C RNASEH2A | Chronic leukemia |
| HP:0030880 | 0.000510933199563 | 1.0 | RNASEH2C RNASEH2A | Raynaud phenomenon |
| HP:0012490 | 0.000634492208607 | 1.0 | RNASEH2C RNASEH2A | Panniculitis |
| HP:0001063 | 0.000701280862145 | 1.0 | RNASEH2C RNASEH2A | Acrocyanosis |
| HP:0003819 | 0.000844876467251 | 1.0 | RNASEH2C RNASEH2A | Death in childhood |
| HP:0003207 | 0.000921683418819 | 1.0 | RNASEH2C RNASEH2A | Arterial calcification |
| HP:0002132 | 0.00100182980306 | 1.0 | RNASEH2C RNASEH2A | Porencephalic cyst |
| HP:0004934 | 0.00100182980306 | 1.0 | RNASEH2C RNASEH2A | Vascular calcification |
| HP:0011915 | 0.00117214086958 | 1.0 | RNASEH2C RNASEH2A | Cardiovascular calcification |
| HP:0000625 | 0.00117214086958 | 1.0 | RNASEH2C RNASEH2A | Eyelid coloboma |
| GO:0032299 | 0.00135247023414 | 1.0 | RNASEH2C RNASEH2A | ribonuclease H2 complex |
| HP:0002139 | 0.00135580966681 | 1.0 | RNASEH2C RNASEH2A | Arrhinencephaly |
| HP:0010994 | 0.00135580966681 | 1.0 | RNASEH2C RNASEH2A | Abnormal corpus striatum morphology |
| HP:0100614 | 0.00145265321444 | 1.0 | RNASEH2C RNASEH2A | Myositis |
| HP:0025323 | 0.00145265321444 | 1.0 | RNASEH2C RNASEH2A | Abnormal arterial physiology |
| HP:0011226 | 0.00155283619475 | 1.0 | RNASEH2C RNASEH2A | Aplasia/Hypoplasia of the eyelid |
| HP:0006579 | 0.00155283619475 | 1.0 | RNASEH2C RNASEH2A | Prolonged neonatal jaundice |
| HP:0007108 | 0.00176322045339 | 1.0 | RNASEH2C RNASEH2A | Demyelinating peripheral neuropathy |
| HP:0002371 | 0.00187342173173 | 1.0 | RNASEH2C RNASEH2A | Loss of speech |
| HP:0001087 | 0.0022240621628 | 1.0 | RNASEH2C RNASEH2A | Developmental glaucoma |
| HP:0002313 | 0.00234762117185 | 1.0 | RNASEH2C RNASEH2A | Spastic paraparesis |
| HP:0002828 | 0.00392717282801 | 1.0 | RNASEH2C RNASEH2A | Multiple joint contractures |
| HP:0000961 | 0.00425777666302 | 1.0 | RNASEH2C RNASEH2A | Cyanosis |
| HP:0002385 | 0.00460173822874 | 1.0 | RNASEH2C RNASEH2A | Paraparesis |
| HP:0002323 | 0.00552008221488 | 1.0 | RNASEH2C RNASEH2A | Anencephaly |
| HP:0001357 | 0.00571376931014 | 1.0 | RNASEH2C RNASEH2A | Plagiocephaly |
| HP:0000965 | 0.00591079583808 | 1.0 | RNASEH2C RNASEH2A | Cutis marmorata |
| HP:0001433 | 0.00611116179869 | 1.0 | RNASEH2C RNASEH2A | Hepatosplenomegaly |
| HP:0001609 | 0.00611116179869 | 1.0 | RNASEH2C RNASEH2A | Hoarse voice |
| HP:0000253 | 0.00631486719198 | 1.0 | RNASEH2C RNASEH2A | Progressive microcephaly |
| HP:0010622 | 0.00673229627659 | 1.0 | RNASEH2C RNASEH2A | Neoplasm of the skeletal system |
| HP:0002180 | 0.00738348564858 | 1.0 | RNASEH2C RNASEH2A | Neurodegeneration |
| HP:0003552 | 0.00760722763793 | 1.0 | RNASEH2C RNASEH2A | Muscle stiffness |
| HP:0001640 | 0.00806472991466 | 1.0 | RNASEH2C RNASEH2A | Cardiomegaly |
| HP:0002510 | 0.00877602907484 | 1.0 | RNASEH2C RNASEH2A | Spastic tetraplegia |
| HP:0011344 | 0.00901980766025 | 1.0 | RNASEH2C RNASEH2A | Severe global developmental delay |
| HP:0100578 | 0.00926692567834 | 1.0 | RNASEH2C RNASEH2A | Lipoatrophy |
| HP:0025454 | 0.0124928176442 | 1.0 | RNASEH2C RNASEH2A | Abnormal CSF metabolite level |
| HP:0004942 | 0.0124928176442 | 1.0 | RNASEH2C RNASEH2A | Aortic aneurysm |
| HP:0002415 | 0.0145966602306 | 1.0 | RNASEH2C RNASEH2A | Leukodystrophy |
| HP:0002187 | 0.0161995879155 | 1.0 | RNASEH2C RNASEH2A | Intellectual disability, profound |
| HP:0009125 | 0.0172014177186 | 1.0 | RNASEH2C RNASEH2A | Lipodystrophy |
| HP:0009145 | 0.0182333024158 | 1.0 | RNASEH2C RNASEH2A | Abnormal cerebral artery morphology |
| HP:0002514 | 0.0185839428468 | 1.0 | RNASEH2C RNASEH2A | Cerebral calcification |
| HP:0000958 | 0.0234461568244 | 1.0 | RNASEH2C RNASEH2A | Dry skin |
| HP:0001909 | 0.0242442812341 | 1.0 | RNASEH2C RNASEH2A | Leukemia |
| HP:0002960 | 0.0254665135939 | 1.0 | RNASEH2C RNASEH2A | Autoimmunity |
| HP:0008936 | 0.0254665135939 | 1.0 | RNASEH2C RNASEH2A | Muscular hypotonia of the trunk |
| HP:0005484 | 0.0254665135939 | 1.0 | RNASEH2C RNASEH2A | Postnatal microcephaly |
| HP:0000737 | 0.0267188008477 | 1.0 | RNASEH2C RNASEH2A | Irritability |
| HP:0002617 | 0.0306559919738 | 1.0 | RNASEH2C RNASEH2A | Dilatation |
| HP:0030163 | 0.0334310605282 | 1.0 | RNASEH2C RNASEH2A | Abnormal vascular physiology |
| HP:0000952 | 0.0358354520556 | 1.0 | RNASEH2C RNASEH2A | Jaundice |
| HP:0002063 | 0.0363263486591 | 1.0 | RNASEH2C RNASEH2A | Rigidity |
| HP:0002061 | 0.0424775836499 | 1.0 | RNASEH2C RNASEH2A | Lower limb spasticity |
| HP:0002134 | 0.0435495415392 | 1.0 | RNASEH2C RNASEH2A | Abnormality of the basal ganglia |
| HP:0001369 | 0.0435495415392 | 1.0 | RNASEH2C RNASEH2A | Arthritis |
| HP:0010766 | 0.047406586281 | 1.0 | RNASEH2C RNASEH2A | Ectopic calcification |
| HP:0004374 | 0.0485386539584 | 1.0 | RNASEH2C RNASEH2A | Hemiplegia/hemiparesis |
| HP:0009124 | 0.0496840793666 | 1.0 | RNASEH2C RNASEH2A | Abnormal adipose tissue morphology |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RNASEH2C | RNASEH2A | 1.0 | 0.949 | hein_WMM hein (RNASEH2A) fraction |
Images
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Complex HuMAP2_04588 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RNASEH2A | HuMAP2_00183 HuMAP2_01100 HuMAP2_01825 HuMAP2_02047 HuMAP2_03593 HuMAP2_04588 HuMAP2_05586 |
| RNASEH2C | HuMAP2_00183 HuMAP2_00457 HuMAP2_01100 HuMAP2_01825 HuMAP2_02047 HuMAP2_03593 HuMAP2_04588 |