hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04594
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | UniProt NCBI |
| PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8847453 | 1.00555407742e-05 | 1.0 | PIP4K2B PIP4K2C | Synthesis of PIPs in the nucleus |
| REAC:R-HSA-6811555 | 6.03332446455e-05 | 1.0 | PIP4K2B PIP4K2C | PI5P Regulates TP53 Acetylation |
| KEGG:00562 | 0.000362555397177 | 1.0 | PIP4K2B PIP4K2C | Inositol phosphate metabolism |
| KEGG:04070 | 0.000610727119751 | 1.0 | PIP4K2B PIP4K2C | Phosphatidylinositol signaling system |
| REAC:R-HSA-6804758 | 0.000729026706133 | 1.0 | PIP4K2B PIP4K2C | Regulation of TP53 Activity through Acetylation |
| REAC:R-HSA-1660499 | 0.00189044166556 | 1.0 | PIP4K2B PIP4K2C | Synthesis of PIPs at the plasma membrane |
| KEGG:04810 | 0.00253730419006 | 1.0 | PIP4K2B PIP4K2C | Regulation of actin cytoskeleton |
| WP:WP51 | 0.00322133819403 | 1.0 | PIP4K2B PIP4K2C | Regulation of Actin Cytoskeleton |
| REAC:R-HSA-6811558 | 0.00393171644273 | 1.0 | PIP4K2B PIP4K2C | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-199418 | 0.00477638186777 | 1.0 | PIP4K2B PIP4K2C | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-1483255 | 0.00503279815751 | 1.0 | PIP4K2B PIP4K2C | PI Metabolism |
| MIRNA:hsa-miR-6729-3p | 0.00713713207894 | 1.0 | PIP4K2B PIP4K2C | hsa-miR-6729-3p |
| GO:2000786 | 0.0126230555186 | 1.0 | PIP4K2B PIP4K2C | positive regulation of autophagosome assembly |
| REAC:R-HSA-5633007 | 0.0205233587202 | 1.0 | PIP4K2B PIP4K2C | Regulation of TP53 Activity |
| GO:0044090 | 0.0247952876258 | 1.0 | PIP4K2B PIP4K2C | positive regulation of vacuole organization |
| REAC:R-HSA-1483257 | 0.0282158474125 | 1.0 | PIP4K2B PIP4K2C | Phospholipid metabolism |
| REAC:R-HSA-1257604 | 0.0422332712518 | 1.0 | PIP4K2B PIP4K2C | PIP3 activates AKT signaling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PIP4K2B | PIP4K2C | 0.392 | 0.554 | hein_WMM bioplex_WMM boldt youn_WMM hein (PIP4K2C) gupta_WMM boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_04594 has an average edge precision of 0.554 which is ranked 2175 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PIP4K2B | HuMAP2_01753 HuMAP2_02385 HuMAP2_02924 HuMAP2_03783 HuMAP2_04594 HuMAP2_06570 |
| PIP4K2C | HuMAP2_02924 HuMAP2_03783 HuMAP2_04594 HuMAP2_06570 |