hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04597
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ORC3 | Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) | UniProt NCBI |
| ORC2 | Origin recognition complex subunit 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1032 | 5.02777038712e-06 | 1.0 | ORC2 ORC3 | ORC 2-4 complex (origin recognition 2-4 complex) |
| CORUM:1034 | 1.00555407742e-05 | 1.0 | ORC2 ORC3 | ORC 2-5 complex (origin recognition 2-5 complex) |
| CORUM:1038 | 1.67592346237e-05 | 1.0 | ORC2 ORC3 | ORC 1-5 complex (origin recognition 1-5 complex) |
| CORUM:389 | 2.51388519356e-05 | 1.0 | ORC2 ORC3 | ORC complex (origin recognition complex) |
| CORUM:1033 | 2.51388519356e-05 | 1.0 | ORC2 ORC3 | ORC complex (origin recognition complex) |
| REAC:R-HSA-68616 | 2.51388519356e-05 | 1.0 | ORC2 ORC3 | Assembly of the ORC complex at the origin of replication |
| CORUM:5251 | 2.51388519356e-05 | 1.0 | ORC2 ORC3 | Ku-ORC complex |
| CORUM:1031 | 2.51388519356e-05 | 1.0 | ORC2 ORC3 | ORC complex (origin recognition complex) |
| REAC:R-HSA-113507 | 6.03332446455e-05 | 1.0 | ORC2 ORC3 | E2F-enabled inhibition of pre-replication complex formation |
| REAC:R-HSA-68689 | 9.21757904306e-05 | 1.0 | ORC2 ORC3 | CDC6 association with the ORC:origin complex |
| WP:WP466 | 0.000320792526609 | 1.0 | ORC2 ORC3 | DNA Replication |
| REAC:R-HSA-113510 | 0.000387138319809 | 1.0 | ORC2 ORC3 | E2F mediated regulation of DNA replication |
| WP:WP45 | 0.000727651340845 | 1.0 | ORC2 ORC3 | G1 to S cell cycle control |
| REAC:R-HSA-68962 | 0.000884887588134 | 1.0 | ORC2 ORC3 | Activation of the pre-replicative complex |
| KEGG:04110 | 0.00104170846513 | 1.0 | ORC2 ORC3 | Cell cycle |
| REAC:R-HSA-176187 | 0.00111616502594 | 1.0 | ORC2 ORC3 | Activation of ATR in response to replication stress |
| WP:WP179 | 0.00248511748256 | 1.0 | ORC2 ORC3 | Cell Cycle |
| REAC:R-HSA-68827 | 0.00286750504412 | 1.0 | ORC2 ORC3 | CDT1 association with the CDC6:ORC:origin complex |
| REAC:R-HSA-68867 | 0.00381775364729 | 1.0 | ORC2 ORC3 | Assembly of the pre-replicative complex |
| REAC:R-HSA-68949 | 0.004164669804 | 1.0 | ORC2 ORC3 | Orc1 removal from chromatin |
| REAC:R-HSA-69002 | 0.00598304676068 | 1.0 | ORC2 ORC3 | DNA Replication Pre-Initiation |
| REAC:R-HSA-69052 | 0.00656291627866 | 1.0 | ORC2 ORC3 | Switching of origins to a post-replicative state |
| REAC:R-HSA-69239 | 0.0115688996608 | 1.0 | ORC2 ORC3 | Synthesis of DNA |
| GO:0000808 | 0.0126230555186 | 1.0 | ORC2 ORC3 | origin recognition complex |
| GO:0005664 | 0.0126230555186 | 1.0 | ORC2 ORC3 | nuclear origin of replication recognition complex |
| REAC:R-HSA-69306 | 0.0131978972662 | 1.0 | ORC2 ORC3 | DNA Replication |
| REAC:R-HSA-69206 | 0.014052618232 | 1.0 | ORC2 ORC3 | G1/S Transition |
| REAC:R-HSA-453279 | 0.0179843346747 | 1.0 | ORC2 ORC3 | Mitotic G1-G1/S phases |
| REAC:R-HSA-69242 | 0.0210512746109 | 1.0 | ORC2 ORC3 | S Phase |
| REAC:R-HSA-69481 | 0.023229975112 | 1.0 | ORC2 ORC3 | G2/M Checkpoints |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ORC3 | ORC2 | 0.109 | 0.378 | bioplex_WMM youn_WMM Malo gupta_WMM fraction |
Images
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Complex HuMAP2_04597 has an average edge precision of 0.378 which is ranked 3542 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ORC3 | HuMAP2_00864 HuMAP2_01115 HuMAP2_02994 HuMAP2_04533 HuMAP2_04597 |
| ORC2 | HuMAP2_00864 HuMAP2_02994 HuMAP2_04398 HuMAP2_04533 HuMAP2_04597 |