hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04599
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MCCC2 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) | UniProt NCBI |
| MCCC1 | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7190 | 1.67592346237e-06 | 1.0 | MCCC2 MCCC1 | 3-methylcrotonyl-CoA carboxylase |
| HP:0004357 | 3.33943267688e-06 | 1.0 | MCCC2 MCCC1 | Abnormal circulating leucine concentration |
| HP:0008281 | 2.00365960613e-05 | 1.0 | MCCC2 MCCC1 | Acute hyperammonemia |
| REAC:R-HSA-3371599 | 3.51943927099e-05 | 1.0 | MCCC2 MCCC1 | Defective HLCS causes multiple carboxylase deficiency |
| REAC:R-HSA-3323169 | 4.69258569465e-05 | 1.0 | MCCC2 MCCC1 | Defects in biotin (Btn) metabolism |
| HP:0010892 | 7.01280862145e-05 | 1.0 | MCCC2 MCCC1 | Abnormal circulating branched chain amino acid concentration |
| REAC:R-HSA-196780 | 9.21757904306e-05 | 1.0 | MCCC2 MCCC1 | Biotin transport and metabolism |
| KEGG:00280 | 0.000157715245211 | 1.0 | MCCC2 MCCC1 | Valine, leucine and isoleucine degradation |
| REAC:R-HSA-70895 | 0.000286582912066 | 1.0 | MCCC2 MCCC1 | Branched-chain amino acid catabolism |
| REAC:R-HSA-3296482 | 0.000351943927099 | 1.0 | MCCC2 MCCC1 | Defects in vitamin and cofactor metabolism |
| GO:0004485 | 0.000450823411379 | 1.0 | MCCC2 MCCC1 | methylcrotonoyl-CoA carboxylase activity |
| GO:1905202 | 0.000450823411379 | 1.0 | MCCC2 MCCC1 | methylcrotonoyl-CoA carboxylase complex |
| GO:0002169 | 0.000450823411379 | 1.0 | MCCC2 MCCC1 | 3-methylcrotonyl-CoA carboxylase complex, mitochondrial |
| HP:0002919 | 0.000571042987746 | 1.0 | MCCC2 MCCC1 | Ketonuria |
| HP:0002179 | 0.00135580966681 | 1.0 | MCCC2 MCCC1 | Opisthotonus |
| HP:0001987 | 0.00345631282057 | 1.0 | MCCC2 MCCC1 | Hyperammonemia |
| GO:0006552 | 0.00450823411379 | 1.0 | MCCC2 MCCC1 | leucine catabolic process |
| REAC:R-HSA-5668914 | 0.00641543501397 | 1.0 | MCCC2 MCCC1 | Diseases of metabolism |
| HP:0001992 | 0.00652191201795 | 1.0 | MCCC2 MCCC1 | Organic aciduria |
| GO:0016421 | 0.00676235117068 | 1.0 | MCCC2 MCCC1 | CoA carboxylase activity |
| HP:0001531 | 0.00716308309191 | 1.0 | MCCC2 MCCC1 | Failure to thrive in infancy |
| HP:0001259 | 0.00877602907484 | 1.0 | MCCC2 MCCC1 | Coma |
| GO:0006551 | 0.00946729163895 | 1.0 | MCCC2 MCCC1 | leucine metabolic process |
| GO:0016885 | 0.00946729163895 | 1.0 | MCCC2 MCCC1 | ligase activity, forming carbon-carbon bonds |
| REAC:R-HSA-196849 | 0.0100471611569 | 1.0 | MCCC2 MCCC1 | Metabolism of water-soluble vitamins and cofactors |
| HP:0025356 | 0.0116412623116 | 1.0 | MCCC2 MCCC1 | Psychomotor retardation |
| HP:0001942 | 0.0124928176442 | 1.0 | MCCC2 MCCC1 | Metabolic acidosis |
| HP:0002157 | 0.0133744278709 | 1.0 | MCCC2 MCCC1 | Azotemia |
| HP:0004364 | 0.0139788651854 | 1.0 | MCCC2 MCCC1 | Abnormal circulating nitrogen compound concentration |
| HP:0003112 | 0.0158723235132 | 1.0 | MCCC2 MCCC1 | Abnormality of serum amino acid level |
| GO:0006768 | 0.0162296428096 | 1.0 | MCCC2 MCCC1 | biotin metabolic process |
| HP:0004354 | 0.0222740159548 | 1.0 | MCCC2 MCCC1 | Abnormal circulating carboxylic acid concentration |
| REAC:R-HSA-196854 | 0.024074640537 | 1.0 | MCCC2 MCCC1 | Metabolism of vitamins and cofactors |
| HP:0001254 | 0.0293135400377 | 1.0 | MCCC2 MCCC1 | Lethargy |
| HP:0012072 | 0.047406586281 | 1.0 | MCCC2 MCCC1 | Aciduria |
| HP:0001943 | 0.0496840793666 | 1.0 | MCCC2 MCCC1 | Hypoglycemia |
| HP:0006573 | 0.0497341708567 | 0.5 | MCCC1 | Acute hepatic steatosis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MCCC2 | MCCC1 | 1.0 | 0.949 | bioplex_WMM Guru boldt Malo fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_04599 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MCCC2 | HuMAP2_01941 HuMAP2_04067 HuMAP2_04599 HuMAP2_05526 |
| MCCC1 | HuMAP2_01941 HuMAP2_02020 HuMAP2_03882 HuMAP2_04067 HuMAP2_04599 HuMAP2_05526 |