hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04606
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NDUFAF4 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa) | UniProt NCBI |
| NDUFA13 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Cell death regulatory protein GRIM-19) (Complex I-B16.6) (CI-B16.6) (Gene associated with retinoic and interferon-induced mortality 19 protein) (GRIM-19) (Gene associated with retinoic and IFN-induced mortality 19 protein) (NADH-ubiquinone oxidoreductase B16.6 subunit) | UniProt NCBI |
| ERCC8 | DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA) | UniProt NCBI |
| NDUFA3 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (Complex I-B9) (CI-B9) (NADH-ubiquinone oxidoreductase B9 subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4324 | 5.27244283038e-06 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | Mitochondrial complex I assembly model OXPHOS system |
| REAC:R-HSA-6799198 | 2.97715563398e-05 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | Complex I biogenesis |
| REAC:R-HSA-611105 | 0.000180191665247 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | Respiratory electron transport |
| REAC:R-HSA-163200 | 0.000340340039133 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:04714 | 0.000399392690129 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | Thermogenesis |
| REAC:R-HSA-1428517 | 0.000984664941346 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | The citric acid (TCA) cycle and respiratory electron transport |
| HP:0011400 | 0.00298968747372 | 0.75 | NDUFA13 NDUFAF4 ERCC8 | Abnormal CNS myelination |
| CORUM:178 | 0.00390833076865 | 0.5 | NDUFA3 NDUFA13 | Respiratory chain complex I (holoenzyme), mitochondrial |
| HPA:026020_03 | 0.00604381730336 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | liver; hepatocytes[Uncertain,High] |
| GO:0010257 | 0.0130360493673 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | NADH dehydrogenase complex assembly |
| GO:0032981 | 0.0130360493673 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | mitochondrial respiratory chain complex I assembly |
| KEGG:00190 | 0.0136880283161 | 0.5 | NDUFA3 NDUFA13 | Oxidative phosphorylation |
| WP:WP4396 | 0.0154631487697 | 0.5 | NDUFA3 NDUFA13 | Nonalcoholic fatty liver disease |
| KEGG:05012 | 0.0156041830743 | 0.5 | NDUFA3 NDUFA13 | Parkinson disease |
| KEGG:04723 | 0.0171226599156 | 0.5 | NDUFA3 NDUFA13 | Retrograde endocannabinoid signaling |
| KEGG:04932 | 0.0173825101547 | 0.5 | NDUFA3 NDUFA13 | Non-alcoholic fatty liver disease (NAFLD) |
| KEGG:05010 | 0.0232850911193 | 0.5 | NDUFA3 NDUFA13 | Alzheimer disease |
| HP:0012447 | 0.0257035156736 | 0.75 | NDUFA13 NDUFAF4 ERCC8 | Abnormal myelination |
| HP:0002921 | 0.0295907808511 | 0.75 | NDUFA13 NDUFAF4 ERCC8 | Abnormality of the cerebrospinal fluid |
| HP:0001138 | 0.0300060012618 | 0.5 | NDUFA13 NDUFAF4 | Optic neuropathy |
| KEGG:05016 | 0.03037774612 | 0.5 | NDUFA3 NDUFA13 | Huntington disease |
| HPA:040010_03 | 0.031444391961 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | seminal vesicle; glandular cells[Uncertain,High] |
| HPA:004020_03 | 0.0319520963736 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | breast; glandular cells[Uncertain,High] |
| HP:0011017 | 0.0321477366073 | 0.75 | NDUFA13 NDUFAF4 ERCC8 | Abnormal cellular physiology |
| HP:0025354 | 0.034595498986 | 0.75 | NDUFA13 NDUFAF4 ERCC8 | Abnormal cellular phenotype |
| HPA:047020_02 | 0.0352936444685 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | soft tissue 1; chondrocytes[Uncertain,Medium] |
| HP:0008972 | 0.0413775694569 | 0.5 | NDUFA13 NDUFAF4 | Decreased activity of mitochondrial respiratory chain |
| HPA:039010_03 | 0.0416307958449 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | salivary gland; glandular cells[Uncertain,High] |
| GO:0033108 | 0.0424904593616 | 0.75 | NDUFA3 NDUFAF4 NDUFA13 | mitochondrial respiratory chain complex assembly |
| HP:0011922 | 0.0427529847392 | 0.5 | NDUFA13 NDUFAF4 | Abnormal activity of mitochondrial respiratory chain |
| HP:0000817 | 0.0441507593067 | 0.5 | NDUFA13 NDUFAF4 | Poor eye contact |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ERCC8 | NDUFA13 | 0.103 | 0.366 | bioplex (NDUFA13) bioplex_WMM |
| NDUFA3 | NDUFA13 | 0.091 | 0.354 | bioplex (NDUFA13) bioplex_WMM boldt boldt_WMM |
| NDUFAF4 | NDUFA13 | 0.059 | 0.328 | bioplex (NDUFA13) bioplex_WMM boldt boldt_WMM |
| NDUFA3 | ERCC8 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| ERCC8 | NDUFAF4 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| NDUFA3 | NDUFAF4 | 0.006 | 0.003 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_04606 has an average edge precision of 0.177 which is ranked 6455 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NDUFAF4 | HuMAP2_00408 HuMAP2_01573 HuMAP2_03703 HuMAP2_04606 HuMAP2_04892 HuMAP2_05273 |
| NDUFA13 | HuMAP2_00408 HuMAP2_01573 HuMAP2_02247 HuMAP2_04606 HuMAP2_05273 |
| ERCC8 | HuMAP2_00408 HuMAP2_04606 HuMAP2_05273 HuMAP2_06252 |
| NDUFA3 | HuMAP2_00408 HuMAP2_01573 HuMAP2_04606 HuMAP2_05273 |